Italian scientists claim world-first coronavirus vaccine breakthrough

An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital. (Reuters/File Photo)
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Updated 05 May 2020
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Italian scientists claim world-first coronavirus vaccine breakthrough

  • A coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time

ROME: An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital.

Luigi Aurisicchio, CEO of  Takis, the firm developing the medication, said that a coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time.

“This is the most advanced stage of testing of a candidate vaccine created in Italy,” Aurisicchio told the Italian newsagency ANSA. “Human tests are expected after this summer,” he added.

“According to Spallanzani Hospital, as far as we know we are the first in the world so far to have demonstrated a neutralization of the coronavirus by a vaccine. We expect this to happen in humans too,” said Aurisicchio.

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He explains that Takis is exploring “more interesting technological platforms with LineaRx, an American company.

“We are working hard for a vaccine coming from Italian research, with an all-Italian and innovative technology, tested in Italy and made available to everyone. In order to reach this goal we need the support of national and international institutions and partners who may help us speed up the process.”

Aurisicchio added: “This is not a competition. If we join our forces and skills together we can all win against coronavirus.”

Italian researchers describe the results “encouraging and well beyond expectations.”

After a single vaccination, the mice developed antibodies that can block the virus from infecting human cells, Aurisicchio said.

After observing that the five vaccine candidates generated a large number of antibodies, researchers selected the two with the best results.

Serum was isolated from the antibody-rich blood; it was then analyzed in the virology laboratory of the Spallanzani Institute, one of the most advanced establishments in Europe. The next step now is to understand how much the immune response lasts.

All of the vaccine candidates currently being developed are based on the material genetic of DNA protein “spike”, the molecular tip used by the coronavirus to enter human cells.

They are injected with the so-called “electroporation” technique, which consists of an intramuscular injection followed by a brief electrical impulse, helping the vaccine break into the cells and activating the immune system.

Researchers believe that this makes their vaccine particularly effective for generating functional antibodies against the “spike” protein, in particular in the lung cells, which are the most vulnerable to coronavirus.  

“So far, the immunity generated by most of our five vaccine candidates has an effect on the virus. We expect even better results after the second vaccination,” said Dr Emanuele Marra from Takis.

Marra added that those vaccine candidates could adapt to any COVID-19 evolutions and its possible mutations.

“We are already working on a trial version in case the virus accumulates mutations and becomes invisible to the immune system. For this purpose, we use the same concept we use in developing cancer vaccines,” he said.


Myanmar, Afghan hopeful scholars mourn UK study visa ban

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Myanmar, Afghan hopeful scholars mourn UK study visa ban

  • Myanmar, Afghanistan, Sudan and Cameroon citizens will be barred from obtaining university visas
  • Britain’s travel block is “really painful” for Afghan women hoping to escape to an education abroad, said one female

YANGON, Myanmar: Aspiring students are lamenting Britain’s ban on education visas for their war-weary countries — dashing dreams of bettering themselves and their home nations.
Myanmar, Afghanistan, Sudan and Cameroon citizens will be barred from obtaining university visas, London announced this week, saying asylum applications by visiting students had “rocketed” nearly 500 percent from 2021 to 2025.
“It’s like the country is punishing the weak, the most vulnerable people,” said one woman from Myanmar.
She was preparing for a scholarship interview for a master’s in climate change finance when her plans were upended by Downing Street’s decree on Wednesday.
“I could not focus the whole morning,” the 28-year-old told AFP from Yangon, speaking on condition of anonymity for security reasons in a country riven by civil war since a 2021 military coup.
“I can’t picture my future.”
Like in much of the developed world, immigration has become a divisive issue in Britain.
Efforts to beat back arrivals mirror the sweeping travel bans issued by US President Donald Trump which have shut out citizens of Myanmar, Sudan and Afghanistan.
Since the chaotic military withdrawal of Britain, the United States and other NATO nations in 2021, Afghanistan has been ruled by a resurgent Taliban government which has banned women over age 12 from attending school.
Britain’s travel block is “really painful” for Afghan women hoping to escape to an education abroad, said one female child social worker in Ghazni province, who asked to remain anonymous for security reasons.
She has now canceled her plans to study for a master’s in both the US and the UK.
“Now I am trying to be hopeful, but I think it would also be a mistake,” said the 27-year-old.
In the summer of 2024, Arefa Mohammadi fled to neighboring Pakistan, living in limbo as she applied to universities.
She got an offer to study public health in England but now cannot accept it.
“It was truly shocking for me,” said the 24-year-old.
“This situation put me in a place where I haven’t any goals, because all my goals and all my futures are unpredictable.”

- ‘Cruel and short-sighted’ -
In Kabul, a 39-year-old man faces similar heartbreak.
He was accepted to study specialist subjects related to water management at three universities in England and Scotland.
“When I was a child I witnessed several challenges like flash floods, water scarcity, environmental neglect, inefficient irrigation systems,” he said, asking to remain anonymous for security reasons. “To address these challenges I made my application.”
“I hoped to acquire modern knowledge. It’s impossible to acquire in Afghanistan,” he added.
Some 33 million people in the country face severe water shortages, aid agencies say, a result of compounding multi-year droughts, climate change and infrastructure battered by decades of war.
Britain’s Labour government made the decision to curb visas as the right-wing Reform UK party surges in opinion polls with its hard-line stance against immigration.
The UK Home Office said almost 135,000 asylum seekers had entered the country through legal routes since 2021.
Activist organization Burma Campaign UK called the visa ban “exceptionally cruel and shortsighted.”
“The opportunity to come to the UK to study is life-changing for the individual student but also an investment in the future of Myanmar,” said program director Zoya Phan in a statement.
One exiled Myanmar journalist has been living over the border in Thailand after escaping the military rule which has clamped down on press freedoms.
“When the military coup happened I was just 22, so I had a lot of dreams,” she said. “But over the past five years there have been a lot of struggles — I couldn’t complete my dreams.”
Every year since the junta takeover she applied for further education to buoy her spirits.
But she received an email Thursday morning canceling her place to study for a master’s at a London university.
“Everything is gone,” she said. “My UK dream is all disappeared.”