LONDON: A manufacturer of a possible COVID-19 vaccine being developed by British scientists said on Friday it may know by the end of May if it can make a million doses a month with a view to building stocks for commercial supply when the vaccine is approved.
Cobra Biologics is one of the firms working to make a potential vaccine known as ChAdOx1 nCoV-19 being developed by scientists at the University of Oxford.
Chief Executive Peter Coleman said the firm is not responsible for proving the efficacy of the vaccine, with those trials being run by the Oxford team, and there was a lot of risk involved in the project.
But he said that if a 200-liter manufacturing run planned for the middle of May were successful, the company would be ready to produce 1 million doses a month.
“(That’s) more than enough for clinical trials, but also potentially a start to stock up for commercial supply,” Coleman told Reuters, adding that it could have capacity for up to two million doses in repeat batches.
“The speed at which we’re operating is much quicker than it ordinarily is. And to start building up batches for commercial supply before you’ve even got to phase one (clinical trials) is pretty unusual.”
British pharmaceutical firm AstraZeneca has joined the Oxford vaccine program to develop, produce and distribute the potential vaccine to help make it available as soon as possible if it succeeds in clinical trials.
Coleman said AstraZeneca’s involvement could help with the rapid scaling-up of the vaccine on a global stage, but said that Cobra Biologics and two other contract development and manufacturing organizations (CDMOs) with a similar capacity that were already involved would still play a pivotal role.
“The current consortium of CDMOs will be a fundamental part of the manufacturing of this vaccine. AstraZeneca has a lot of capability,” he said.
“But I think at this moment in time, given the intensity and speed that’s required, it makes common sense to stick with the CDMOs you’ve got at the moment and then at some point in the future, transition to something else.”
Coleman said that processes that might previously have taken years were being boiled down to five months, and that safety work already carried out on a Middle East respiratory syndrome (MERS) vaccine could help speed up the development of a COVID-19 vaccine.
“It’s not from a standing start. There’s been a lot of work, and the products have been modified in such a way that the safety work from the early clinical trials is equally applicable,” Coleman said.
Asked about comments by AstraZeneca CEO Pascal Soriot that it will know whether the vaccine will be effective in June or July, Coleman said that his firm was focused on the manufacture of the vaccine rather than determining its efficacy.
“I trust the university with that July outcome,” he said. “And then if it’s positive, the race is on to produce as many batches as possible.”
Potential UK coronavirus vaccine producer eyes making a million doses a month
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Potential UK coronavirus vaccine producer eyes making a million doses a month
- Cobra Biologics is one of the firms working to make a potential vaccine known as ChAdOx1 nCoV-19
- British pharmaceutical firm AstraZeneca has also joined the Oxford vaccine program
Polish flag carrier LOT cancels Friday flights to Tel Aviv and Beirut, PAP reports
- Decisions about future flights would be made on an ongoing basis
WARSAW: Polish national airline LOT canceled flights on Friday to Tel Aviv and Beirut due to the unstable situation in the region, a spokesperson was quoted as saying by state news agency PAP.
“Today’s flight 151/152 to Israel from Warsaw and to Beirut 143/144 have been canceled,” Krzysztof Moczulski told PAP. He said decisions about future flights would be made on an ongoing basis.
French police arrest man who threatened to blow himself up at Iran’s Paris consulate
PARIS: A man who had threatened to blow himself up at Iran’s consulate in Paris was arrested by police, a police source said.
French police earlier cordoned off the Iranian consulate, Reuters reporters saw.
A police source told Reuters the man was seen at about 11 am (0900 GMT) entering the consulate, carrying what appeared to be a grenade and explosive vest.
Police earlier said they were at the scene and asked the public to avoid the area but provided no further details.
Service was interrupted on a nearby metro line for security reasons, the RATP metro company said.
A person at the Iranian embassy who responded to a call from Reuters declined to provide any information on the situation.
It was unclear whether the incident had any link to the escalating tensions between Iran and Israel.
Earlier on Friday, explosions echoed over the Iranian city of Isfahan in what sources described as an Israeli attack, but Tehran played down the incident and indicated it had no plans for retaliation — a response that appeared gauged toward averting region-wide war.
Blinken says US ‘not involved in any offensive operation’
- ‘All I can say is for our part and for all the members of the G7 our focus is on de-escalation’
CAPRI, Italy: US Secretary of State Antony Blinken on Friday refused to comment on reports of an attack by Israel on Iran, beyond saying Washington was “not involved in any offensive operation.”
Speaking to journalists after a meeting with G7 counterparts in Italy, he declined to answer repeated questions about explosions in Iran, and reports that Israel had carried out retaliatory strikes.
“I’m not going to speak to these reported events... All I can say is for our part and for all the members of the G7 our focus is on de-escalation,” Blinken told a press conference on the island of Capri.
“The US has not been involved in any offensive operation,” he said.
Speaking to reporters earlier, G7 host Antonio Tajani, the foreign minister of Italy, said Washington had been informed in advance of the strikes, without giving details.
“The United States were informed at the last moment,” he said, adding that “it was just information” passed on — without saying who by.
The reports dominated the G7 Friday, with Tajani forced to change the agenda, but little public information emerged.
In its final statement, the Group of Seven ministers said: “In light of reports of strikes on April 19th, we urge all parties to work to prevent further escalation. The G7 will continue to work to this end.”
Israel had warned it would hit back after Iran fired hundreds of missiles and drones at Israel almost a week ago, in retaliation for a deadly strike — which Tehran blamed on its foe — that levelled Iran’s consular annex at its embassy in Syria.
Indians head to the polls in world’s biggest election
- Polling takes place in phases over the next six weeks, with results expected on June 4
- Over 968 million people are registered to vote, with 168.6 million casting ballots on Friday
NEW DELHI: Indian voters headed to the polls on Friday for the first phase of the world’s biggest general election, in which Prime Minister Narendra Modi is aiming for a rare third consecutive term.
More than 968 million people are registered to vote, with polling taking place over the next six weeks, as results are expected on June 4.
After April 19, the other voting dates will be April 26, May 7, May 13, May 20, May 25 and June 1, with some states completing the process on a single day, and others having it spread out in several phases.
Friday’s polling was held in 21 states and union territories, including the most populous ones such as Uttar Pradesh, Bihar, Rajasthan, Tamil Nadu, and Maharashtra, as well as smaller northeastern states and the northern Himalayan territory of Jammu and Kashmir.
In Kashmir, this is the first election since its special autonomous status and statehood were scrapped through the Indian government’s controversial constitutional amendment in 2019.
Chief Election Commissioner of India Rajiv Kumar told reporters on Friday that 168.6 million people were expected to cast their ballots on Friday.
“The preparations started, actually, two years back. Wide range of preparations … It’s a tremendous exercise,” he said.
MAIN CONTENDERS
More than 2,600 political parties are registered in the marathon election and 543 contested seats in the lower house of Parliament. The party or coalition that wins at least 272 is going to form the government.
Modi is targeting 400 seats for the National Democratic Alliance led by his Hindu nationalist Bharatiya Janata Party, which has been in power since 2014.
He is challenged by an alliance of two dozen opposition parties — the Indian National Developmental Inclusive Alliance, or INDIA, led by the Congress Party, which has ruled the country for close to 45 years since its independence in 1947.
The key leader of the opposition coalition is Rahul Gandhi — the son of Rajiv Gandhi, a grandson of Indira Gandhi, and a great-grandson of Jawaharlal Nehru, all of whom served as prime ministers of India.
While the opposition is trying to appeal to Indian youth with promises to tackle unemployment, free education and medical facilities, the BJP has deployed the same tactics as in previous polls — by mobilizing voters through majoritarian Hindu sentiment, despite constitutional provisions that make it a secular state.
Opinion polls show Modi as frontrunner, with 48 percent of respondents in the most recent survey released by the Centre for the Study of Developing Societies last week naming him as their choice for the prime minister. Gandhi was second, preferred by 27 percent.
“Modi has created an image of a powerful leader, a leader who is not only popular in India but outside too. He has also created an image of not pandering to Muslim communities in India … This image of a leader who does not appease the Muslim sentiments appeals to the Hindu masses. Politics of polarization helps Modi to build an image and aura among a large section of the Hindu voters,” Prof. Venkat Narayan, political analyst and commentator, told Arab News.
“Then the use of social media and the mainstream media is also there to create an image and broaden Modi’s appeal. The media plays a great role in creating this image, they are soft towards Modi and do not ask critical questions.”
If Modi wins the election, he will become the second prime minister, after Nehru, to succeed in three consecutive polls.
“Modi is leading in the polls as he has created an image of doing a lot for different sections of the society. Besides, he projects himself as squeaky clean. People also think that as he has no children, he has no reason to be corrupt or be on the take,” Sanjay Kapoor, analyst and editor of the English-language political magazine Hardnews, told Arab News.
“There are other reasons for his popularity, which include adroit use of media and social media that control all criticism against him. Then there are issues of raising India’s global profile and pursuing an independent foreign policy.”
FUTURE FOREIGN POLICY
Whoever wins the election, the foreign policy direction is likely to remain broadly unchanged, except for India’s orientation toward Israel and Palestine.
Support for Palestine and Palestinian statehood was once an integral part of India’s foreign policy, but in recent years, under Modi’s rule, New Delhi has become closer to Tel Aviv, despite civil society protests breaking out across the country against Israel’s deadly war on Gaza.
“If the INDIA alliance comes to power, then we may see a change in our policy towards Israel and Palestine. The INDIA alliance is sympathetic to Palestinians,” Kapoor said.
“We expect that the INDIA alliance will also restore ties with neighbors like Pakistan, (and) revive SAARC (South Asian Association for Regional Cooperation).”
The member states of SAARC — a regional intergovernmental organization and geopolitical union of states in South Asia — are Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka.
The last biennial SAARC summit was hosted by Nepal in 2014. Pakistan was to host the summit in 2016, but it was stalled after India refused to participate, following an attack on an Indian army camp in Kashmir that New Delhi blamed on Pakistan-based militants.
VOTERS’ CONCERNS
According to the Centre for the Study of Developing Societies survey, unemployment emerged as the top concern for 27 percent of respondents.
Some 62 percent also said it has been more difficult to find a job in the last five years — during Modi’s second term in office.
“The biggest concern remains inflation and unemployment. The possibility of getting a job decreases if you study more. People are forced to leave India in search of jobs. Some have even gone as far as Russia and Israel,” Kapoor said. “The situation is really dismal.”
Rising prices and inflation were also a major issue — the top concern for 23 percent of the people surveyed by the CSDS.
“Women and the middle class are concerned about the rising prices. Modi is trying to divert attention from these main issues by talking about religion and temples,” said Shashi Shekhar Singh, associate professor at Satyawati College at the University of Delhi.
The CSDS pre-poll also revealed that despite the ruling party’s narrative promoting Hindu nationalist dominance to establish a majoritarian state in India, only 11 percent of respondents saw India as solely for Hindus.
But there were fears the reality on the ground could change if the BJP tried to amend India’s liberal and democratic constitution.
“Indian secularism and the very idea of a plural democracy is at stake,” Singh said.
“There is a fear that if the BJP comes to power with the thumping majority, the liberal and secular democracy will breathe its last. The BJP might lead the nation further down the path of a Hindu majoritarian state.”
ASEAN says ‘deeply concerned’ over escalating Myanmar violence
- ASEAN foreign ministers urge ‘all parties for an immediate cessation of violence’ in Myanmar
BANGKOK: Regional bloc ASEAN said it is “deeply concerned” about a recent upsurge in fighting in Myanmar, after fierce clashes over a key trading hub near the Thai border.
The foreign ministers of the Association of Southeast Asian Nations urged “all parties for an immediate cessation of violence” in Myanmar, which has been roiled by conflict since the military seized power in a February 2021 coup.
The ministers’ statement issued late Thursday said ASEAN was “deeply concerned over the recent escalation of conflicts, including in the area of Myawaddy.”
The military was last week forced to pull its troops out of positions in the valuable trading post after days of battling with the Karen National Union (KNU) — a long-established ethnic minority armed group — and other anti-junta fighters.
It was the latest blow suffered by the junta, which has suffered a string of battlefield losses in recent months, with some analysts warning it is its most significant threat to date.
Myawaddy is Myanmar’s main trade link to Thailand, and usually sees over a billion dollars worth of trade annually.
The clashes saw people flee across the border into Thailand — from where gunfire and the boom of artillery barrages could be heard.
Thailand has said it is ready to receive people from Myanmar, though the kingdom’s foreign minister warned it would not tolerate any violation of its sovereignty.
