Pakistan likely to be first to complete research in immunoglobulin therapy to treat COVID-19 

Dow University of Health Sciences (DUHS) researchers work on an intravenous immunoglobulin (C-IVIG) therapy project in Karachi, Pakistan, on December 11, 2020. (AN photo)
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Updated 02 March 2021
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Pakistan likely to be first to complete research in immunoglobulin therapy to treat COVID-19 

  • Scientists at Karachi’s Dow University of Health Sciences say ‘severe’ patients who had received the treatment had a 100 percent recovery rate
  • In critical patients the recovery ratio was 50 to 60 percent, number of hospitalization days reduced to 6.5 from up to 25

KARACHI: Scientists at Karachi’s Dow University of Health Sciences (DUHS) who are conducting clinical trials of intravenous immunoglobulin (C-IVIG) therapy for the treatment coronavirus, say Pakistan is likely to become the first country to complete the research needed to introduce the treatment at a mass level, saying ‘severe’ patients who had received the product had a 100 percent recovery rate.
The therapy uses immunoglobulin (IG), a blood product extracted from the plasma of people who have recovered from infection, and which is rich in the antibodies that target the virus. Continuous infusion of immunoglobin can neutralize the infection in patients and shorten the course of the disease, Pakistani scientists say.
In June, DUHS trials started on 30 participants, most from the high-risk group of people above the age of 60, with many suffering from diabetes, hypertension and other comorbidities.
“The trials are very encouraging and remarkable,” Dr. Shaukat Ali, head of biotechnology at DUHS and lead on the C-IVIG project, told Arab News. “At the moment, what we have seen is that all severe patients who received C-IVIG treatment had 100 percent recovery ratio while in critical patients the recovery ratio was 50 to 60 percent.”
Besides the high recovery rate, Ali said, the DUHS team had observed that the treatment had significantly reduced the period of hospitalization.
“The results show that the number of hospitalization days were reduced to six and a half days for severe patients, which is very encouraging because normally a severe patient would occupy hospital resources for 20 to 25 days.”




Dr. Shaukat Ali, head of biotechnology at Dow University of Health Sciences (DUHS), speaks to Arab News at his office in Karachi, Pakistan, on December 11, 2020. (AN photo)

Ali said Pakistan was the first country to develop the immunoglobulin solution in April 2020.
“Only a week ago, an announcement was made by a global plasma alliance of big companies of blood producers, including Takeda Pharmaceutical, to work on the project,” Ali added, referring to the CoVIg-19 Plasma Alliance.
Global pharmaceutical giants — Takeda Pharmaceutical of Japan, CSL Limited of Australia, German Biotest AG and private companies from France, Switzerland and United Kingdom — announced research on plasma-based treatment for COVID-19 in early April, but the projects had been delayed several times.
In Pakistan, clinical research started in June, after a series of regulatory approvals. The experiment was also registered with the National Library of Medicine at the National Institutes of Health in the United States, which maintains the biggest global registry of clinical trials.
“Pakistan is the first country in the world which has accomplished the experiment and announced it. There are two clinical trials going on which were registered after us; one is carried out by National Institutes of Health in the US and another one in Israel, both were registered after us,” Ali said.

The Drug Regulatory Authority of Pakistan (DRAP) authorized clinical trials for critically ill COVID-19 patients in mid-April. In the same month, DUHS purified immunoglobulin from the plasma of COVID-19 patients and prepared IVIG formulation to treat severe and critical virus cases.
To seek more plasma donors, DUHS scientists announced the outcome of their trials on November 21, ahead of their scheduled completion in January 2021.
“With the onset of winter, hospitals are full with patients and we want to alert the authorities that we have the solution that we have developed indigenously and to motivate general public to donate plasma,” Ali added.
The announcement was met with substantial public response.
“We are getting plasma from donors and proceeding faster now. We will complete the trial within a month and go for next phase which will be multicentric, where we will add more people across the country at different centers.”


Separated twice: An Afghan man’s life in Pakistan and the fear of losing home again

Updated 27 January 2026
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Separated twice: An Afghan man’s life in Pakistan and the fear of losing home again

  • Lost as a child in Peshawar, Mohammad Rahim Khan built a life in Pakistan but remains undocumented
  • Deportation drive of ‘illegal’ foreigners exposes legal gaps around adoption, marriage, refugee status

ISLAMABAD: Mohammad Rahim Khan was five years old when he last saw his mother.

It was at the Hajji Camp bus stop in Pakistan’s northwestern city of Peshawar, more than four decades ago. His mother, an Afghan refugee fleeing war, had brought him across the Tari Mangal border in Kurram district and into Pakistan. While waiting at the crowded terminal, Khan wandered to a nearby toy shop. When he returned, she was gone.

He searched for her for two days. She never came back.

A local shopkeeper, Ali Muhammad, took pity on the child and brought him home, promising to help find his family. The temporary shelter became permanent. Khan grew up in Pakistan, adopted informally into the household, and never returned to Afghanistan.

Now 45, he lives on the outskirts of Islamabad in a modest two-room house, working as a daily wage laborer. But a nationwide deportation drive launched by Pakistan in 2023 has placed his entire life under threat.

Since November 2023, authorities have deported nearly 2 million Afghan nationals, targeting those without legal documentation. Khan, who has remained undocumented throughout his adult life, fears he may soon be among them.

“I spoke to my lawyer that I am very worried,” Khan told Arab News. “I love Pakistan.”

A FAMILY WITHOUT PAPERS

Ali Muhammad later married Khan to his daughter, Gul Mina. Together, they have six children, four daughters and two sons. Yet despite decades in Pakistan, Khan’s Afghan nationality continues to shadow the family.

Khan never held an Afghan refugee card, Afghan Citizen Card (ACC), Proof of Registration (POR), or any other formal documentation. His family assumed for decades that his informal adoption, marriage to a Pakistani citizen, and long residence would provide sufficient legal standing. They only sought legal advice when the deportation drive began threatening separation.

Without a Pakistani national identity card, his children cannot obtain Form-B, the birth registration document required for school enrolment.

“They [children] are told to get a Form-B,” Gul Mina told Arab News. “Otherwise, they will not go to school.”

Three of their daughters were forced to leave school after eighth grade.

Healthcare has also been affected. When Khan’s 13-year-old son, Ehsanullah, fractured his arm, a public hospital refused to issue a registration card without identity documents.

“Then I went to a [private clinic] in Chak Shahzad and got my treatment there,” Khan said.

The family has petitioned the Islamabad High Court to block his deportation. Lawyers say the case highlights how thousands of long-term residents fall through legal cracks created by Pakistan’s citizenship, refugee and documentation framework.

LEGAL GREY ZONE

Pakistan does not legally recognize Western-style adoption. Instead, it uses a guardianship system under the 1890 Guardians and Wards Act, aligning with Islamic principles that preserve lineage, so adopted children don’t inherit or change their family name but receive care, education and welfare through court-appointed guardianship.

“Because we don’t have a legal pathway for adoption per se, the adopted child does not get citizenship of the adopting parents automatically,” said Advocate Umer Ijaz Gillani, a legal expert on citizenship.

Years earlier, Khan’s father-in-law had offered to register him as his biological son to obtain identity documents, but Khan refused, calling the move fraudulent. Because Khan later married his father-in-law’s daughter, both he and his wife cannot legally list the same person as their father on official records, leaving them without a lawful workaround.

Marriage offers no certainty either. Pakistan’s Citizenship Act of 1951 grants citizenship to foreign women married to Pakistani men, but is silent on foreign husbands married to Pakistani women.

While higher courts have, at times, ruled in favor of such men, implementation has been inconsistent. In October 2025, the Supreme Court struck down a high court order that had directed authorities to grant citizenship to an Afghan man married to a Pakistani woman.

Even the Pakistan Origin Card (POC), a long-term residency document, remains difficult to secure.

“We have experienced that in the case of especially Afghan men who marry Pakistani women, the government authorities are often reluctant to recognize this right,” Gillani said.

According to submissions made by government officials in court, authorities have received at least 117 applications for nationality from Afghan men married to Pakistani women following directives issued by the Peshawar High Court, reflecting a broader pattern rather than isolated cases.

‘NO RELAXATION’

Officials say the deportation policy allows no exceptions.

“No relaxation has been granted by the government, including for those who’ve married to Pakistani citizens,” said Asmatullah Shah, the chief commissionerate for Afghan refugees.

“If they want to live here, they should go back and apply for a visa and then they can come here with valid documentation.”

Legal experts note that deportation would send Khan to Afghanistan despite having no known relatives there, and that returning legally would require obtaining an Afghan passport and a Pakistani visa, costs far beyond the means of a daily wage laborer.

For Khan’s mother-in-law, Husn Pari, who raised him for decades as her own son, the prospect is devastating.

“When I am not able to meet [Khan] for one day, my day does not pass,” she said. “His own mother, how much pain must she be in?”

For Khan, the fear of deportation echoes the trauma of his childhood.

“Before I was separated from my first mother,” he said. “The second time I will be separated from my second mother. This is very difficult for me.”