Pakistan likely to be first to complete research in immunoglobulin therapy to treat COVID-19 

Dow University of Health Sciences (DUHS) researchers work on an intravenous immunoglobulin (C-IVIG) therapy project in Karachi, Pakistan, on December 11, 2020. (AN photo)
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Updated 02 March 2021
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Pakistan likely to be first to complete research in immunoglobulin therapy to treat COVID-19 

  • Scientists at Karachi’s Dow University of Health Sciences say ‘severe’ patients who had received the treatment had a 100 percent recovery rate
  • In critical patients the recovery ratio was 50 to 60 percent, number of hospitalization days reduced to 6.5 from up to 25

KARACHI: Scientists at Karachi’s Dow University of Health Sciences (DUHS) who are conducting clinical trials of intravenous immunoglobulin (C-IVIG) therapy for the treatment coronavirus, say Pakistan is likely to become the first country to complete the research needed to introduce the treatment at a mass level, saying ‘severe’ patients who had received the product had a 100 percent recovery rate.
The therapy uses immunoglobulin (IG), a blood product extracted from the plasma of people who have recovered from infection, and which is rich in the antibodies that target the virus. Continuous infusion of immunoglobin can neutralize the infection in patients and shorten the course of the disease, Pakistani scientists say.
In June, DUHS trials started on 30 participants, most from the high-risk group of people above the age of 60, with many suffering from diabetes, hypertension and other comorbidities.
“The trials are very encouraging and remarkable,” Dr. Shaukat Ali, head of biotechnology at DUHS and lead on the C-IVIG project, told Arab News. “At the moment, what we have seen is that all severe patients who received C-IVIG treatment had 100 percent recovery ratio while in critical patients the recovery ratio was 50 to 60 percent.”
Besides the high recovery rate, Ali said, the DUHS team had observed that the treatment had significantly reduced the period of hospitalization.
“The results show that the number of hospitalization days were reduced to six and a half days for severe patients, which is very encouraging because normally a severe patient would occupy hospital resources for 20 to 25 days.”




Dr. Shaukat Ali, head of biotechnology at Dow University of Health Sciences (DUHS), speaks to Arab News at his office in Karachi, Pakistan, on December 11, 2020. (AN photo)

Ali said Pakistan was the first country to develop the immunoglobulin solution in April 2020.
“Only a week ago, an announcement was made by a global plasma alliance of big companies of blood producers, including Takeda Pharmaceutical, to work on the project,” Ali added, referring to the CoVIg-19 Plasma Alliance.
Global pharmaceutical giants — Takeda Pharmaceutical of Japan, CSL Limited of Australia, German Biotest AG and private companies from France, Switzerland and United Kingdom — announced research on plasma-based treatment for COVID-19 in early April, but the projects had been delayed several times.
In Pakistan, clinical research started in June, after a series of regulatory approvals. The experiment was also registered with the National Library of Medicine at the National Institutes of Health in the United States, which maintains the biggest global registry of clinical trials.
“Pakistan is the first country in the world which has accomplished the experiment and announced it. There are two clinical trials going on which were registered after us; one is carried out by National Institutes of Health in the US and another one in Israel, both were registered after us,” Ali said.

The Drug Regulatory Authority of Pakistan (DRAP) authorized clinical trials for critically ill COVID-19 patients in mid-April. In the same month, DUHS purified immunoglobulin from the plasma of COVID-19 patients and prepared IVIG formulation to treat severe and critical virus cases.
To seek more plasma donors, DUHS scientists announced the outcome of their trials on November 21, ahead of their scheduled completion in January 2021.
“With the onset of winter, hospitals are full with patients and we want to alert the authorities that we have the solution that we have developed indigenously and to motivate general public to donate plasma,” Ali added.
The announcement was met with substantial public response.
“We are getting plasma from donors and proceeding faster now. We will complete the trial within a month and go for next phase which will be multicentric, where we will add more people across the country at different centers.”


Police lodge case in prominent Pakistani businessman’s ‘kidnapping’ in Karachi after court intervention

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Police lodge case in prominent Pakistani businessman’s ‘kidnapping’ in Karachi after court intervention

  • Zulfiqar Ahmed, owner of Paracha Textile Mills and Mezan Group, was abducted from Karachi’s Mauripur area
  • Official says high-powered police teams formed to investigate the matter, hoping that it will be resolved soon

KARACHI: Police have registered a case into the “kidnapping” of a prominent Pakistani businessman in Karachi on the intervention of a high court, his lawyer said on Saturday, three days after the incident.
Zulfiqar Ahmed, managing director of Paracha Textile Mills and Mezan Group, was kidnapped from Mauripur Road on July 23 after he left his office in Sher Shah area, according to the police report. A white Toyota Surf vehicle intercepted their car and eight armed men forced Ahmed and his friend, Qaiser, into it before dropping Ahmed’s friend off a short distance away.
Ahmed’s friend informed about the kidnapping his family and the company, which submitted an application in the Kalri police station on the same day. When the police refused to register a complaint, the family requested the Sindh High Court (SHC) to intervene in the matter. Mian Ali Ashfaq, the counsel representing Ahmed and his family, said police registered a case after the court orders.
“The news [of Ahmed’s abduction] somehow gained traction on social media,” Ashfaq told Arab News on Saturday. “After social media spotlight about court order and my protest, my team of office associates went to the police station, where, after four hours, the FIR [First Information Report] was finally registered and a copy was provided to us by Friday afternoon.”
Pakistanis widely shared news about Ahmed’s abduction across social media platforms, calling on authorities to take steps for the release of the businessman, who is also widely regarded for his charity work.
Asad Raza, deputy inspector-general (DIG) of Karachi’s South district where the incident occurred, dismissed the allegations of police inaction in the case and said they had been working on it since it was first reported to them.
“It is insubstantial whether the FIR is registered instantly or after one day’s delay as long as we were working on the case when the abduction took place,” he told Arab News.
Ashfaq, counsel of the Ahmed family, said the SHC had issued notices to respondents and fixed the matter for a hearing on Tuesday. “We hope that Zulfiqar Ahmed will be recovered and reunited with the family before the next hearing,” he added.
On Friday, Karachi Police Chief Javed Alam Odho said two high-powered teams were investigating the case.
“A high-powered team, under the supervision of the DIG of the CIA [Crime Investigation Agency of police] and another under the DIG of the area, are working on it,” Odho told Arab News. “I am confident this case will be resolved soon.”


Authorities warn of floods, landslides as monsoon currents likely to penetrate parts of Pakistan

Updated 27 July 2024
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Authorities warn of floods, landslides as monsoon currents likely to penetrate parts of Pakistan

  • This year, Pakistan recorded its ‘wettest April since 1961,’ with 59.3mm rainfall and 144 deaths in thunderstorms, house collapses
  • A top UN official last month warned that an estimated 200,000 people in Pakistan could be affected by the upcoming monsoon season

ISLAMABAD: Pakistan’s National Disaster Management Authority (NDMA) on Saturday warned of flash floods and landslides as monsoon currents were likely to penetrate upper parts of the country over the next five days.
The monsoon currents from Arabian Sea may cause heavy rains from July 27 till July 31. Under the influence of this system, rainfall could trigger landslides, mudslides and cause boulders to fall, potentially disrupting roads, according to the NDMA.
The areas that are likely to be affected include upper parts of the Khyber Pakhtunkhwa province, Galiyat, Murree, Gilgit-Baltistan and Azad Kashmir. The rainfall can trigger hill torrents in Sulaiman and Kirthar mountain ranges as well as in DG Khan and Rajanpur regions.
“Flash floods can strike suddenly, catching people off guard,” the NDMA said in a statement. “Population at risk is advised to avoid flood waters and find a safe location away from flood-prone areas.”
The authority said it had issued instructions to all relevant departments to take necessary precautions to mitigate the possible effects of flooding and extreme weather.
“Even a mere six inches of moving water can knock you off your feet, and just one foot of moving water can sweep away a vehicle,” the NDMA noted in its advisory for the masses.
“Bridges can be hazardous during floods. Avoid crossing them if water is flowing rapidly. Avoid staying in weak structures. In case of intense rain, seek shelter in safe places such as schools, government buildings, or any concrete buildings.”
Pakistan is recognized as one of the most vulnerable countries to climate change effects in the world. This year, the South Asian country recorded its “wettest April since 1961,” with 59.3 millimeters rainfall and at least 144 deaths in thunderstorms and house collapses, mostly in Khyber Pakhtunkhwa, according to the authorities.
Last month, a UN official warned that an estimated 200,000 people in Pakistan could be affected by the upcoming monsoon season, which is expected to bring heavier rains than usual.
The United Nations, with help from local authorities, has prepared a contingency plan, with $40 million set aside to respond to any emergencies, said Mohamed Yahya, the newly appointed Resident Coordinator and Humanitarian Coordinator in Pakistan.
Unusually heavy rains in June 2022 triggered flash floods in many parts of the country, killing over 1,700 people, inflicting losses of around $30 billion, and affecting at least 30 million people.


Pakistani religious party vows to continue sit-in in Rawalpindi despite government’s offer for talks

Updated 27 July 2024
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Pakistani religious party vows to continue sit-in in Rawalpindi despite government’s offer for talks

  • Jamaat-e-Islami supporters have been holding a sit-in at a key intersection in Rawalpindi since Friday
  • The party wants the government to address cost-of-living crisis, remove additional taxes in the budget

ISLAMABAD: Jamat-e-Islami (JI), a Pakistani religio-political party, on Saturday vowed to continue its sit-in in Rawalpindi against the rising cost of living and additional taxes imposed in the latest budget, despite the government forming a negotiation committee for talks with the protesters.
The JI, led by Hafiz Naeem-ur-Rehman, announced the sit-in in Islamabad to call for a reduction in power tariff amid soaring inflation and to review Pakistan’s agreements with independent power producers (IPPs).
The party’s caravans entered the capital from different directions as the district administration closed the capital’s Red Zone, which houses top government offices and the diplomatic enclave, with shipping containers and roads leading to parliament.
“Our dharna will continue as long as the government accepts our demands for a significant reduction in inflation and electricity prices,” Aamir Baloch, a JI spokesperson, told Arab News.
“The party chief Hafiz Naeem-ur-Rehman will be announcing a fresh strategy for the protests, dharna and engagement with the government today afternoon.”
The government has formed a three-member committee, which includes Information Minister Attaullah Tarar and two senior members of the ruling Pakistan Muslim League-Nawaz (PML-N) party, to hold talks with the JI leadership.
“We are ready for negotiations, but don’t disrupt public life,” Tarar said at a news conference on Friday. “The government’s three-member committee will talk to you. Amir Muqam, Tariq Fazal Chaudhry and I will negotiate with you. Whenever you express willingness, we are ready for the negotiations.”
But Baloch said the party would continue its protest and JI chief Rehman would join the sit-in at Zero Point — a major intersection in the city where various key roads and highways connect with each other — on Saturday.
He said thousands of JI workers had already reached the area, despite the government’s “brutalities.”
“The police have arrested dozens of our peaceful workers from D-Chowk,” he said, referring to a key spot close to the parliament building in Islamabad.
“The government wants to incite the peaceful protesters through such strong-arm tactics. It will be responsible for any law-and-order situation, if our workers are not released immediately.”
Police in the capital have deployed additional contingents, including personnel with riot gears, to prevent any untoward incident.
The Rawalpindi-Islamabad Expressway has also been closed with shipping containers near the Zero Point bridge, where the JI protesters have gathered.
Baloch said the party leadership would announce their future course of action after reaching Zero Point.
“One thing is for sure,” he said. “We are here to stay and will definitely stage a sit-in to press the government to meet our legitimate demands regarding inflation and taxes.”


Protesters in northwest Pakistan end weeklong sit-in after CM assures no military operation being launched

Updated 27 July 2024
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Protesters in northwest Pakistan end weeklong sit-in after CM assures no military operation being launched

  • Pakistan’s government last month announced a new campaign to counter a fresh surge in militancy in areas along the border with Afghanistan
  • The announcement raised fears among locals as past operations displaced hundreds of thousands of people and destroyed livelihoods in region

PESHAWAR: Thousands of protesters, who had been staging a sit-in in Pakistan’s Bannu district for a week, on Friday called off their protest after Chief Minister Ali Amin Gandapur assured them that no military operation was being launched in the northwestern Khyber Pakhtunkhwa (KP) province.
Pakistan’s government last month announced a new campaign to counter a fresh surge in militancy in areas along the border with Afghanistan. Major opposition parties opposed the operation and in Bannu — where eight soldiers were killed in a suicide bombing last week — thousands held rallies to call for peace and security.
One of the key demands of the protesters in Bannu was for the government to not launch any new military operation in the province. They demanded that a spike in militant attacks in the region be tackled by empowering and better equipping civilian agencies like the police and the counter-terrorism department (CTD).
On Friday, CM Gandapur traveled to Bannu where he spoke to the protesters and announced at a rally that all their demands had been accepted in letter and spirit, lauding local elders for helping avert violence when two protesters were killed after gunfire triggered a stampede at the rally on June 19.
“I have a signed copy [of the demands]. It has been done the way you [protesters] wanted,” he told the gathering. “I’m the owner of this soil and land, no one can oppress me or coerce me. As chief minister, I declare that there will be no operation in the province.”
The announcement came a day after the provincial apex committee, which comprises civilian leaders and military commanders in the province, met to discuss the situation in Bannu. The KP government later clarified that police and the CTD would be tasked to take action against militants amid a surge in violence in the area.
The resentment for military operation stems from past displacement of hundreds of thousands of people and destruction of countless homes and businesses in successive military campaigns in KP that began in 2014. But Pakistani military spokesman Lt Gen Ahmed Sharif Chaudhry dispelled the fears this week, saying the newly proposed Azm-e-Istehkam campaign was not meant to be a full-scale military operation.
“We have offered sacrifices for our homeland and stood loyal to the country and its people. We left our homes and became nomads for our land and for the sake of peace,” Gandapur said. “We will offer sacrifices again but we will make the decisions ourselves and will not allow anyone to impose their decisions.”
The chief minister appreciated police for taking swift action against illegal armed groups in Bannu.
Provincial Minister for Public Health Engineering Pakhtunyar Khan, who hails from Bannu, said the people of the region had experienced “unspeakable hardships” for the sake of peace.
“We want peace for the entire province and we will not back down from this demand,” Khan said at the rally.
On Thursday, the apex committee said the judiciary would be requested to hold an inquiry into the Bannu shooting incident, a demand that had been put forward by protesters and Pakistan’s opposition alliance.
“Meanwhile, the government will hold its own inquiry and identify the persons responsible,” it said in a statement.


Pakistan plans to launch panda bonds, seeks cooperation of Chinese capital market investors

Updated 27 July 2024
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Pakistan plans to launch panda bonds, seeks cooperation of Chinese capital market investors

  • The bonds are denominated in China’s currency and will provide Pakistan access to Chinese capital markets
  • The finance minister also discusses the next CPEC stage, expected to emphasize business-to-business ties

ISLAMABAD: Federal Minister for Finance and Revenue Muhammad Aurangzeb briefed Governor of People’s Bank of China (PBoC) Pan Gongsheng on Pakistan’s plan to launch panda bonds during a meeting in Beijing on Friday in which they discussed a wide range of economic issues.
Panda bonds are sold in China’s domestic market and are denominated in its currency, though they are issued by non-Chinese entities. Pakistan plans to issue these bonds to diversify its funding sources and strengthen its foreign exchange reserves by attracting Chinese investors.
According to local media reports, the initial issuance is expected to raise between $250 million and $300 million, helping Pakistan improve its financial stability amid economic challenges like high inflation and declining forex reserves.
The minister spoke about the government’s economic policy during the meeting in which reprentatives of other financial institutions were also present.
“Underlining Pakistan’s plan to launch panda bonds, Minister for Finance briefed PBoC and other Financial Institutions about the steps taken so far and sought cooperation of the Chinese institutional investors in the capital market to seek benefit from the pro-business policies of the new [Pakistani] Government,” said a statement issued by the finance division after the meeting.
The Pakistani official also highlighted his country’s improving macroeconomic indicators, reforms in tax collection and energy sector and privatization of loss-making state-owned enterprises.
He applauded Chinese President Xi Jinping’s Belt and Road Initiative while reviewing the progress of its flagship China-Pakistan Economic Corridor (CPEC) project.
The minister noted the next phase of CPEC would focus on strengthening business-to-business cooperation, with private sector playing the central role in the development and economic growth.
He arrived in China on Thursday to open talks on power sector structural reforms suggested by the International Monetary Fund, two government sources quoted by Reuters.
Aurangzeb is also accompanied by Pakistan’s Power Minster Awais Ahmed Khan Leghari.
According to Reuters, both officials are expected to take up several proposals with the Chinese side, including reprofiling of nearly $15 billion energy sector debt.