Brazil’s banana spider aids erectile dysfunction treatment

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Scientist Marcia Helena Borges works on the research to develop a medicine to treat erectile dysfunction using banana spider venom at the Federal University of Minas Gerais (UFMG) in Belo Horizonte, state of Minas Gerais, Brazil, on September 21, 2023. (AFP)
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Picture of a banana spider in a container where it is kept at FUNED (Foundation Ezequiel Dias) at the Federal University of Minas Gerais (UFMG) in Belo Horizonte, state of Minas Gerais, Brazil, on September 21, 2023. (AFP)
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Scientist Marcia Helena Borges works on the research to develop a medicine to treat erectile dysfunction using banana spider venom at the Federal University of Minas Gerais (UFMG) in Belo Horizonte, state of Minas Gerais, Brazil, on September 21, 2023. (AFP)
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Updated 28 September 2023
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Brazil’s banana spider aids erectile dysfunction treatment

  • A molecule from the spider's venom triggers the release of nitric oxide, which is essential for an erection
  • Scientist says the research could be especially useful in the fight against cancer

BELO HORIZONTE, Brazil: Three decades ago, Brazilian researchers began studying a curious side effect from banana spider bites: the toxin left victims with priapism, a painful and persistent erection.
The scientists were inspired to develop a synthetic molecule using some properties of the spider’s poison to create a gel to treat erectile dysfunction, which is now undergoing promising clinical trials.
Covered in thick brown hair, and with a maximum size of up to 15 centimeters (six inches), the arachnid is one of the most poisonous in the world.
It is found in several South American countries, and was nicknamed for its common presence in banana plantations, but it is also called the “wandering spider” or “armed spider.”
In the southeastern Brazilian state of Minas Gerais, it is found in rural areas as well as urban centers.
At the Ezequiel Dias Foundation (FUNED), a medical research center in the state’s capital Belo Horizonte, a biologist delicately grabs one of the spiders with a pair of tweezers and stimulates its fangs to get a few drops of venom.
FUNED then sends the venom to the Federal University of Minas Gerais (UFMG) which has been researching which component could be replicated to treat erectile dysfunction, which affects tens of millions of men around the world.
“The venom is only used to learn the properties of the molecule” which causes the priapism in bite victims, said Maria Elena de Lima, a UFMG researcher.
Brazilian biotech company Biozeus has bought the patent for the molecule.
The company wants to sell it in an ointment, which would be rubbed on the male organ when required, resulting in an erection in a few minutes, said de Lima.
The molecule triggers the release of nitric oxide, which is essential for an erection as it increases blood circulation and allows blood vessels to widen.
De Lima said the research could be especially useful in the fight against cancer, as men suffering prostate cancer often refuse a procedure to remove the prostate because it can damage nerves and lead to erectile dysfunction.
After the first phase of clinical trials was approved by Brazil’s Anvisa regulatory agency, the medication has now moved into the second of three phases prior to being approved for sale.
De Lima said the discovery of a potential erectile dysfunction treatment was a message “not to destroy animals, even poisonous ones, because there is a real library of molecules that are still unknown.”
 


This handout photograph released on Jan. 21, 2026, shows a view of prehistoric cave paintings in the Sulawesi island of Indonesia, which includes faded hand stencils dated to at least 67,800 years ago. (AFP Photo/Maxime Aubert/Griffith University)

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This handout photograph released on Jan. 21, 2026, shows a view of prehistoric cave paintings in the Sulawesi island of Indonesia, which includes faded hand stencils dated to at least 67,800 years ago. (AFP Photo/Maxime Aubert/Griffith University)

  • Newly dated artworks are believed to have been created by ancestors of indigenous Australians
  • Discovery shows Sulawesi as one of world’s oldest centers of artistic culture, researcher says 

JAKARTA: Hand stencils found in a cave in Indonesia’s Sulawesi are the world’s oldest known artworks, Indonesian and Australian archeologists have said in a new study that dates the drawings back to at least 67,800 years ago.

Sulawesi hosts some of the world’s earliest cave art, including the oldest known example of visual storytelling — a cave painting depicting human-like figures interacting with a wild pig. Found in 2019, it dates back at least 51,200 years. 

On Muna, an island off the province’s southeast, researchers have discovered new artworks which are faint and partially obscured by a more recent motif on the wall. They used a new dating technique to determine their age. 

The cave art is of two faded hand stencils, one at least 60,900 years old and another dating back at least 67,800 years. This makes it the oldest art to be found on cave walls, authors of the study, which was published this week, said in the journal Nature. 

Adhi Agus Oktaviana, a researcher at the National Research and Innovation Agency, or BRIN, and co-author, said this hand stencil was 16,600 years older than the rock art previously documented in the Maros-Pangkep caves in Sulawesi, and about 1,100 years older than stencils found in Spain believed to have been drawn by Neanderthals.

The discovery “places Indonesia as one of the most important centers in the early history of symbolic art and modern human seafaring. This discovery is the oldest reliably dated rock art and provides direct evidence that humans have been intentionally crossing the ocean since almost 70,000 years ago,” Oktaviana said on Wednesday.

The stencils are located in Liang Metanduno, a limestone cave on Muna that has been a tourist destination known for cave paintings that are about 4,000 years old. 

“This discovery demonstrates that Sulawesi is one of the oldest and most continuous centers of artistic culture in the world, with roots dating back to the earliest phases of human habitation in the region,” said Prof. Maxime Aubert of Australia, another of the study’s co-authors.

To figure out the stencils’ ages, researchers used a technique called laser-ablation uranium-series dating, which allows for the accurate dating of ocher-based rock art. The method uses a laser to collect and analyze a tiny amount of mineral crusts that had formed on top of the art. 

The study also explored how and when Australia first became settled, with the researchers saying the stencil was most likely created by the ancestors of indigenous Australians.