PARIS: Scientists on Friday unveiled a revised classification for diabetes, one they said could lead to better treatments and help doctors more accurately predict life-threatening complications from the disease.
There are five distinct types of diabetes that can occur in adulthood, rather than the two currently recognized, they reported in The Lancet Diabetes & Endocrinology, a leading medical journal.
The findings are consistent with the growing trend toward “precision medicine,” which takes into account differences between individuals in managing disease.
In the same way that a patient requiring a transfusion must receive the right blood type, diabetes sub-types need different treatments, the study suggested.
Similarly, scientists have also identified distinct kinds of microbiome — the bacterial ecosystem in our digestive tract — that can react differently to the same medication, rendering it more or less effective.
“This is the first step toward personalized treatment of diabetes,” said senior author Leif Groop, an endocrinologist at Lund University in Sweden, adding that the new classification is a “paradigm shift” in how the disease is viewed.
People with diabetes have excessively high blood glucose, or blood sugar, which comes from food.
Some 420 million people around the world today suffer from diabetes, with the number expected to rise to 629 million by 2045, according to the International Diabetes Federation.
Currently, the disease is divided into two sub-types.
With type-1 — generally diagnosed in childhood and accounting for about 10 percent of cases — the body simply doesn’t make insulin, a hormone that helps regulate blood sugar levels.
For type-2, the body makes some insulin but not enough, which means glucose stays in the blood.
This form of the disease correlates highly with obesity and can, over time, lead to blindness, kidney damage, and heart disease or stroke. Acute cases may also require limb amputations.
It has long been known that type-2 diabetes is highly variable, but classification has remained unchanged for decades.
For the study, researchers monitored 13,270 newly diagnosed diabetes patients ranging in age from 18 to 97.
By isolating measurements of insulin resistence, insulin secretion, blood sugar levels, age, and the onset of illness, they distinguished five distinct clusters of the disease — three serious and two milder forms.
Among the severe types, a group of patients with insulin resistence — in which cells are unable to use insulin effectively — was at far higher risk of kidney disease.
“This group has the most to gain from the new diagnostics as they are the ones who are currently most incorrectly treated,” Groop said.
Another group facing serious complications was composed of relatively young, insulin-deficient patients.
The third “severe” group were people with auto-immune diabetes corresponding to the original “type-1” diagnosis.
The two other groups have milder types of the disease including one, which includes about 40 percent of the patients, beset with a form of diabetes related to advanced age.
“This will enable earlier treatment to prevent complications in patients who are most at risk of being affected,” said lead author Emma Ahlqvist, an associate professor at Lund University.
The results were checked against three other studies from Sweden and Finland.
“The outcome exceeded our expectations,” said Groop.
The researchers plan to launch similar studies in China and India.
A ‘paradigm shift’ in the diagnosis of diabetes: study
A ‘paradigm shift’ in the diagnosis of diabetes: study
Chef serves up a taste of Spain at Ithra Cultural Days in Saudi Arabia
DHAHRAN: Among the attractions of the Ithra Cultural Days: Spain at the King Abdulaziz Center for World Culture (Ithra), visitors can try a tantalizing selection of Spanish foods — none more renowned than its famous paella.
Arab News spoke with chef Jose Zafra at the event, which runs until Jan. 31, who flew in from Spain to offer a taste of his homeland to the people of Saudi Arabia.
A “master rice cook, paella researcher and promoter,” according to his business card, his logo is even designed around the recognizable cooking pan and the phrase “Pasion por la paella,” or “Passion for paella.”
“That's why the pan is round because people get around and eat all together — to share culture and passion and life,” Zafra told Arab News as foodies lined up behind him, eager to try a plateful.
“It’s not just a food. It’s a link, a connection. Paella is the symbol of unity and sharing. And people now are going to try it — authentic Spanish paella in Saudi Arabia.”
The word “paella” comes from the Latin “patella,” meaning pan.
In Spanish, it refers both to the rice dish itself and the pan in which it is cooked.
Paella was introduced to Spain during Moorish rule. It originated in Valencia, on the country’s eastern coast, as a rural peasant dish that was cooked by farm workers over open fires using local ingredients. Over time, the dish’s popularity spread and other versions evolved, for example featuring seafood and meat.
It is different to Saudi Arabia’s kabsa, a communal dish which similarly uses rice and meat. Kabsa is cooked in a deep pot to ensure the rice stays soft and aromatic from the meaty broth, whereas paella uses a wide, shallow pan to fully absorb flavors evenly, often creating a prized crispy layer at the bottom.
Visitors to Ithra’s Culture Days can enjoy the flavors of Spain made with a sprinkling of local love — true to the origins of the dish.
Find the scoops of Spanish joy near the food truck area and try chicken paella, seafood paella —or both! You will see the signs offering a plate, at SR35 ($9) for chicken and SR40 for seafood, or let your nose lead you there.
Zafra concluded: “The chicken is from here, the seafood is from here — and the passion, well, that is from Spain.”
