Silicon Valley’s Osh Agabi lifts the lid on Koniku’s disease-detection tech

Koniku’s product is undergoing clinical trials in the US to assist in COVID-19 detection. (AFP)
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Updated 20 October 2021

Silicon Valley’s Osh Agabi lifts the lid on Koniku’s disease-detection tech

  • Koniku Kore uses biotech based on mice neurons to detect diseases, chemicals and even explosives
  • Founded in 2015, Koniku aims to revolutionize health security through robotics and synthetic neurobiology

DUBAI: Artificial intelligence and machine-learning technologies are expected to completely transform the way people live, work and do business. But one area where exciting developments are already becoming a reality is in health.

Osh Agabi, originally from Nigeria, has received funding from tech giants in Silicon Valley to develop his “clinical cyborg” — an innovation that aims to detect more than 4,000 smells simultaneously, resulting potentially in the diagnosis of a variety of diseases.

Agabi has drawn the attention of American venture capitalists impressed by his study of human cells grown on a computer chip.

“One thing that has always been a primary driver for me is, how does the human body essentially function?” he told Arab News.

“How is it possible that we are capable of so much? A human being is essentially a machine but a very advanced one.”

Of course, even the most sophisticated machinery can malfunction from time to time, which means the medical tools needed to diagnose and address these issues must evolve and advance.

With this in mind, Agabi launched his own company in 2015, named Koniku — which translates as “immortal” in Nigeria’s Yoruba dialect — specializing in robotics and synthetic neurobiology.

Among its recent creations is the Koniku Kore, which the company says is capable of detecting and interpreting 4,096 different smells at the same time.

“At any given time, you are exhaling literally thousands of different smells, and these different smells are giving us an indication as to the state of your health,” Agabi said.

“If you have a disease, there’s a smell signature associated with it. So, we now have a platform that could potentially be scaled worldwide to offer comprehensive clinical-grade data in everybody’s bathroom, collecting breath in real time and making every individual the CEO of their health.”

Scientists have long recognized the ability of dogs to sniff out human emotions such as fear and sadness and even detect certain cancers and other illnesses.




Scientists have long recognized the ability of dogs to sniff out emotions and illnesses. (Shutterstock)

Agabi and his team have isolated similar brain cells in mice, genetically modified them to carry proteins that allow them to smell the contents of the air and inserted them into a Koniku chip.

The chip is then placed inside the Koniku Kore, which collects air through a mechanical pump and passes it on to the cells. The cells then detect the smell and give off signals that are interpreted by the device’s onboard computer. Weighing just 700 grams, the device is ideal for home use, says the company.

“Our target, before this decade ends, is to have our technology in 10 million homes to analyze disease in real time,” Agabi said.

Some scientists caution that fusing natural proteins with silicon circuits is a daunting task, citing the fragility of cells and the complexity of their interactions with chemical substances.

A CNN web report of 2020 on Koniku quoted Timothy Swager, a chemistry professor at MIT, as saying that to pull off what the company claims would require “some technical miracle.”

Agabi, who completed his PhD studies in bioengineering and computational neuroscience at the ETH Zurich and Imperial College in London, intends to present his invention to potential investors at the upcoming Future Investment Initiative in Riyadh.

“It’s the thing that gets me up every morning and I’m excited about it,” he said.

Agabi is likely to find an enthusiastic crowd of potential investors. He won a startup competition organized by the Misk Global Forum in Saudi Arabia two years ago, so there are sure to be many in the Kingdom’s developing health-tech sector awaiting his return visit.

“It’s something I feel very privileged to do as a person coming from my background, born and bred in Lagos but mostly educated in Europe and now in the US scaling this technology to a global audience,” he said.

Given the healthcare challenges posed by the coronavirus disease (COVID-19) pandemic and the growing commercial interest in home and wearable health tech, Agabi believes there is a ready market for his creation.




Osh Agabi wants to bring that power to humans. (Supplied)

The device is currently undergoing clinical trials with Treximo and the University of Southern Nevada. Given its potential application as a rapid COVID-19 detection test, Koniku hopes to secure emergency use authorization for its product in the near future. From there, the sky is the limit for a whole new range of bio- and neuro-tech.

“Synthetic neurobiology and biotechnology will be big,” Agabi said. “When we have biotechnology or synthetic biology merged with data, machine learning and AI, what is possible is unprecedented. It will be the next big thing.”

Koniku’s customers to date include Airbus, which uses the technology to detect explosive compounds, and Thermo Fisher Scientific, the world’s largest manufacturer of scientific equipment, to sense fentanyl, methamphetamine and other drugs.

Major oil companies in Saudi Arabia are also in discussions with Koniku to use the technology to detect benzene, toluene, ethylene and xylene.

“During the refining process of oil and other such chemical compounds, there are compounds that are given off that might be carcinogenic for human beings, that decrease people’s quality of life, make the place smell bad, and so on,” said Agabi.

“This is what we have with Exxon Mobil, for instance, and for methane emissions and for all the compounds that are byproducts from the oil and gas industry that decrease the quality of life in the area we’re working on.”

Koniku has also explored several possibilities for the application of its innovations in oil exploration. “Think about our technology as a ‘smell cyborg,’ similar to a camera on your phone, for security, for filming or vision,” Agabi said.

“You can use this ‘smell cyborg’ for many more applications across the whole spectrum. But our strongest application and what our vision aims to bring to this world is diagnosing disease on a global scale.”




Given the healthcare challenges posed by the coronavirus disease (COVID-19) pandemic and the growing commercial interest in home and wearable health tech, Agabi believes there is a ready market for his creation. (AFP)

For Agabi, the pandemic has made it abundantly clear that the world needs a global system for disease surveillance, where abnormal breath signatures, propagation and growth rates can be detected. In doing so, sickness, death and economic damage could be avoided.

“It is an unfortunate crisis that has cost a lot of life and sorrow,” he said.

“But one of the things we can take from this is the need for a global disease surveillance system through which we can assess the health of people in different cities or states.”

In an increasingly interconnected world, Agabi says every individual has the potential to be a bioweapon until proven otherwise. The only way to make that transparency possible is to develop a technology stack that is able to scan people’s health on a global scale.

“That is what Koniku puts itself forward as,” Agabi said. “That’s what we seek partnerships on. But that is our larger vision, which, with the right partners and resources, we can realize. That’s why I’m very excited to return to the region and form strong partnerships to build this up.”

Twitter: @CalineMalek


Mikati holds key meetings in effort to restore Arab trust in Lebanon

Updated 44 min 26 sec ago

Mikati holds key meetings in effort to restore Arab trust in Lebanon

  • Interior minister says steps will be taken to prevent smuggling and combat the drugs threat

BEIRUT: Lebanon’s Prime Minister Najib Mikati on Monday held a number of meetings designed to help restore Arab trust in Lebanon, and the country’s diplomatic and economic relationships with Saudi Arabia and other Gulf states.

It followed an agreement, announced in Jeddah on Saturday, by French President Emmanuel Macron and Saudi Arabia’s Crown Prince Mohammed bin Salman to work together to help the people of Lebanon.

The participants in extended meetings at the Grand Serail, the prime minister’s headquarters, included Defense Minister Maurice Selim, Interior Minister Bassam Mawlawi, Foreign Affairs Minister Abdullah Bou Habib, Agriculture Minister Abbas Hajj Hassan and Industry Minister George Boujikian.

Other officials who took part included Acting Director-General of Lebanon Customs Raymond Al-Khoury, Mohammed Choucair, the head of the Lebanese Economic Organizations, and representatives of the Federation of Lebanese-Gulf Businessmen Councils.

Choucair, who is also a former minister, stressed the need for the organizations to work on resuming exports to Saudi Arabia and said: “We discussed new ways of doing that.”

During the meeting, Mikati said that “Saudi Arabia and the Gulf states are fed up of hearing slogans that are not implemented.”

A number of people who were present told Arab News that Mikati stressed the “need to address the gaps,” and that “some issues the Gulf states are complaining about are right. We must recommend measures to address them, such as the establishment of additional towers on the borders with Syria in order to control the border.”

FASTFACT

Prime Minister Najib Mikati said that ‘Saudi Arabia and the Gulf states are fed up of hearing slogans that are not implemented.’

Mawlawi said that discussions had focused on the issue of exports to Saudi Arabia and concerns about smuggling.

He said: “We will take practical measures for anything that might pose a threat to our relations with the Arab states, and I will follow up on all judicial proceedings related to smuggling and combating drugs and captagon.

“We must all take prompt action to control the borders, airport, port and all crossing points, and we must (address) the smuggling happening through Lebanon. We do not disclose all smuggling operations we bust.”

Mawlawi added: “We intercepted a captagon-smuggling operation on Saturday. We are following up on it, and the people involved have been arrested.

“We will give practical answers to the smuggling taking place, and what might pose a threat to our relations with Saudi Arabia and the Gulf states in this regard.”

He also noted that “in the case of seized narcotic substances, even if they are manufactured outside of Lebanon and brought to Lebanon to change the manufacturing company’s name and repackage them, the company’s license will be revoked, its work discontinued and its name announced.”

Regarding a call for the restriction of weapons to Lebanese state institutions as a condition for the restoration of Saudi-Lebanese relations, Mawlawi said: “We are implementing the Lebanese state’s policy and highlighting its interests.”

Nicolas Chammas, head of the Beirut Traders’ Association, said that “the biggest problem remains contraband.” He added: “We will work to make Lebanon, once again, a platform for the export of goods, not contraband. We are required to take swift, serious measures and we will take successive measures in this regard.”

Fouad Siniora, a former president of Lebanon, described Saturday’s Saudi-French statement as being “of exceptional importance in these delicate circumstances.”

It “resolves the controversy regarding many issues raised in the Arab region, especially with regard to Iraq, Syria, Yemen and Lebanon,” he added.


Sudanese protest military coup, deal that reinstated PM

Updated 12 sec ago

Sudanese protest military coup, deal that reinstated PM

  • Footage circulated on social media showed demonstrators marching in different locations in Khartoum and Omdurman
  • In the western Darfur region, the death toll from tribal clashes over the weekend climbed to at least 48 people

CAIRO: Thousands of Sudanese took to the streets Monday in the capital of Khartoum and other cities in the latest protests against the October military coup and subsequent deal that reinstated Prime Minister Abdalla Hamdok.
Footage circulated on social media purportedly showed demonstrators marching in different locations in Khartoum and its sister city of Omdurman. There were also protests in other cities, including Kassala, Sennar and Port Sudan.
Security forces fired tear gas to disperse protesters marching in a street near the presidential palace in Khartoum, activist Nazim Sirag said. He said they also used heavy tear gas to break up a one-day sit-in protest in Khartoum’s district of Bahri. Around a dozen protesters suffered light injuries from tear gas canisters, he said.
In past rounds of demonstrations security forces used violence, including firing live ammunition at protesters, according to activists. At least 44 protesters were killed and hundreds were wounded since the coup, according to the Sudan Doctors Committee, which tracks protester deaths.
The Sudanese military seized power Oct. 25, dissolving the transitional government and arresting dozens of officials and politicians. The takeover upended a fragile planned transition to democratic rule more than two years after a popular uprising forced the removal of longtime autocrat Omar Al-Bashir and his Islamist government.
Hamdok was reinstated last month amid international pressure in a deal that calls for an independent technocratic Cabinet under military oversight. The agreement included the release of government officials and politicians detained since the coup and the formation of an independent technocratic Cabinet led by Hamdok.
The deal, however, was rejected by the pro-democracy movement, which insists on handing over power to a civilian government to lead the transition. The protests came under the slogan of: “No negotiations, no compromise, no power-sharing” with the military.
Monday’s protests were called by the Sudanese Professionals Association and the so-called Resistance Committees, which spearheaded the uprising against Al-Bashir and then the military coup.
Among the protesters’ demands are the restructuring of the military under civilian oversight, purging officers loyal to Al-Bashir and disbanding armed groups including the Rapid Support Forces.
“We will keep on using all peaceful means to reject and resist until the fall of the coup government and the return to the course of democratic transition,” said protester Dalia Mostafa, while taking part in a march in Khartoum.
The Rapid Support Forces are a paramilitary unit notorious for atrocities during the Darfur war and a 2019 massacre of protesters in Khartoum. They are led by Gen. Mohammed Hamdan Dagalo, who is also the deputy head of the ruling sovereign council.
Dagalo is seen as the co-architect of the coup along with Gen. Abdel-Fattah Burhan, head of the ruling body.
Relentless street demonstrations have put pressure on the military and Hamdok to take measures to calm angry protesters and gain their trust. Hamdok has yet to announce his Cabinet, which is likely to face opposition from the pro-democracy movement.
In televised comments over the weekend, Burhan described the deal that reinstated Hamdok as “a true start” for the democratic transition.
He said they were working on crafting a “new political charter” with the aim of establishing a broader consensus among all political forces and movements.
In the western Darfur region, meanwhile, the death toll from tribal clashes over the weekend climbed to at least 48 people, all of them shot dead, according to the Sudan Doctors Committee. It said dozens of others were wounded, some in critical condition.
The fighting grew out of a financial dispute late Saturday between two individuals in a camp for displaced persons in the Kreinik area in West Darfur province.
The clashes continued Sunday, with Arab militias known as janjaweed attacking the camp and torching and looting property, according to Adam Regal, spokesman for the General Coordination for Refugees and Displaced in Darfur.
The clashes in Darfur pose a significant challenge to efforts by Sudan’s transitional authorities to end decades-long rebellions in some areas like war-wrecked region.


Four Iraqi Kurdish fighters killed in attack blamed on Daesh

Updated 06 December 2021

Four Iraqi Kurdish fighters killed in attack blamed on Daesh

  • Five other Peshmerga fighters were wounded in the violence late Sunday in northern Iraq

BAGHDAD: Four Iraqi Kurdish Peshmerga fighters were killed in an attack blamed on the Daesh group, a security official said Monday, the third such assault in less than two weeks.
Five other Peshmerga fighters were wounded in the violence late Sunday in northern Iraq that targeted an outpost north of Kirkuk, the source said.
Kurdish army forces confirmed the deadly attack but did not say how Peshmerga fighters were killed in wounded, in a statement accusing Daesh of responsibility.
It was the third attack blamed on Daesh militants in less than two weeks against the Kurdish fighters in northern Iraq.
On Thursday, Daesh claimed responsibility for an assault south of the Kurdish capital of Irbil that killed at least nine Peshmerga fighters and three civilians.
At the end of November, five Peshmergas were killed in a roadside bombing also claimed by the militant group.
Daesh seized swathes of Iraq in a lightning offensive in 2014, before being beaten back by a counter-insurgency campaign supported by a US-led military coalition.
The Iraqi government declared the extremists defeated in late 2017, although the Daesh retains sleeper cells which still strike security forces with hit-and-run attacks.


Israel: Palestinian car-rammer wounds guard, is shot dead

Updated 06 December 2021

Israel: Palestinian car-rammer wounds guard, is shot dead

  • Palestinians have carried out dozens of stabbing, car-ramming and occasional shooting attacks in recent years
  • Most have been carried out by lone attackers with no known connection to militant groups

JERUSALEM: A 16-year-old Palestinian rammed a vehicle into an Israeli checkpoint in the West Bank overnight, wounding a security guard before being shot and “neutralized” at the scene, the Israeli Defense Ministry said Monday.
Israeli media reported that the alleged attacker was killed, while a ministry official declined to comment further.
The attack came two days after a Palestinian from the occupied West Bank stabbed and wounded an Israeli man just outside Jerusalem’s Old City and tried to stab a Border Police officer before being shot and killed. Video taken by bystanders showed the police continuing to shoot the attacker after he had dropped to the ground and preventing medics from approaching him.
The shooting drew comparisons to a 2016 incident in which an Israeli soldier was caught on camera shooting a wounded Palestinian attacker who was lying on the ground. The soldier was imprisoned for several months in a case that divided the country.
The Israeli Justice Ministry said the two officers involved in Saturday’s shooting were brought in for questioning before being released without conditions. Prime Minister Naftali Bennett and other top officials have praised the officers’ response to the attack.
Palestinians have carried out dozens of stabbing, car-ramming and occasional shooting attacks in recent years. Most have been carried out by lone attackers with no known connection to militant groups, which have praised the attacks without claiming responsibility for them.
Rights groups say Israel sometimes uses excessive force, killing suspected attackers who could have been arrested and did not pose an immediate threat. Israeli officials say forces must make split-second decisions in dangerous situations and that all such incidents are investigated.
Israel captured the West Bank in the 1967 war. The Palestinians want it to form the main part of their future state. The territory’s 2.5 million Palestinian residents live under Israeli military rule, with the internationally recognized Palestinian Authority administering cities and towns.


Lebanese president, PM and parliament speaker express satisfaction with Saudi-French agreement

Updated 06 December 2021

Lebanese president, PM and parliament speaker express satisfaction with Saudi-French agreement

  • MP Ali Darwish, from Mikati’s parliamentary bloc, hopes 'positive signs to emerge in coming days’

BEIRUT: Lebanese Prime Minister Najib Mikati has affirmed his government’s commitment to honoring its undertakings for reform.

Mikati said that his joint phone call on Saturday with Saudi and French leaders was “an important step toward restoring historic brotherly relations with Riyadh.”

A joint Saudi-French statement, following the joint phone call between Saudi Crown Prince Mohammed bin Salman and French President Macron with Mikati, linked “economic aid to Lebanon with the implementation of the required reforms.”

The statement reiterated demands that Lebanon should “implement comprehensive reforms, monitor borders, abide by the Taif Agreement, limit arms to the legitimate state institutions and not be a launching pad for any terrorist acts that destabilize the region (nor) a source of drug trafficking.”

Mikati also said: “I thank President Macron and Crown Prince Mohammed bin Salman for their keenness in maintaining the friendship toward Lebanon.”

Mikati called both President Michel Aoun and Parliament Speaker Nabih Berri and briefed them on the phone call.

Mikati’s media office said that Aoun and Berri “expressed their satisfaction and stressed their adherence to the best relations with Saudi Arabia and all brotherly Arab countries, especially the Gulf Cooperation Council countries.”

Mikati called “all parties in Lebanon to appreciate the sensitivity of the situation and circumstances and not to take any action or interfere in any matter that offends the Arab brothers and harms the Lebanese.”

He added: “It is time to commit again to the policy of disassociation and not to involve ourselves and our country in what has nothing to do with us.”

The Saudi position toward Lebanon left the Lebanese anxiously relieved about the extent of the seriousness of the ruling authority in implementing what was agreed on in Jeddah between French President Emmanuel Macron and Saudi Crown Prince Mohammed bin Salman.

Although Macron succeeded in opening the door to a solution to Lebanon’s diplomatic and economic crisis with Saudi Arabia, and thus the Gulf Cooperation Council countries, after the resignation of Information Minister George Kordahi from the government following his statements about the Kingdom, there is a fear that Hezbollah will continue to embroil Lebanon in regional politics.

However, MP Ali Darwish, who is from Prime Minister Mikati’s parliamentary bloc, expects “positive signs to emerge in the coming days.”

Darwish said that appointing a parliamentary committee to try presidents, ministers and MPs in return for allowing Cabinet sessions to take place was “one of the proposals.”

Darwish told Arab News that “the Saudi-French move has undoubtedly breached the wall of stalemate in Lebanon’s relationship with the Gulf, which Lebanon is keen to be extremely good in the midst of the conflict in the region.”

On the implementation of the French-Saudi statement, Darwish said: “The reforms are contained in the ministerial statement of Prime Minister Mikati’s government, and they are his government’s agenda, and he is striving to achieve them.”

Darwish added: “The most important thing now is to restore the connection that was cut off, to return the ambassadors to Saudi Arabia and some Gulf countries, and to return the Arab ambassadors to Lebanon.”

Darwish said that the Mikati government would “never interfere in the judicial matter, as there is a separation of powers.”

However, he indicated that activating the Parliamentary Council for the Trial of Presidents and Ministers was possible but it required steps to be taken by parliament.

Darwish added: “However, the trade-off between this matter and any other matter, especially the dismissal of the governor of the Banque du Liban, is not on the table.”

Darwish said that Mikati’s concern “is securing the livelihood of the Lebanese people in light of the current severe economic crisis.”

He said work was “now focused on rounding the corners and bringing the views closer.”