UK vaccine team shifting focus to new variant threat

Prof. Robin Shattock, head of the vaccine team at Imperial, said scientists will now use the ribonucleic acid (RNA) technology behind the initial vaccine to target new and emerging coronavirus variants. (Shutterstock/File Photo)
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Updated 26 January 2021
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UK vaccine team shifting focus to new variant threat

  • Scientists worldwide scrambling to target emerging mutations with ‘exciting technology’

LONDON: Scientists at Imperial College London have abandoned testing of their coronavirus vaccine to focus on combating emerging variants of the virus detected around the world.

The decision comes as the scientific community scrambles to get ahead of the new threat, which could require updated inoculations.

Prof. Robin Shattock, head of the vaccine team at Imperial, said scientists will now use the ribonucleic acid (RNA) technology behind the initial vaccine to target new and emerging coronavirus variants.

“Although our first generation vaccine candidate is showing promise in early clinical development, the broader situation has changed with the rapid rollout of approved vaccines,” he said in a statement on Tuesday.

“It is not the right time to start a new efficacy trial for a further vaccine in the UK, with the emphasis rightly placed on mass vaccination in response to the rapid spread of the new variant.”

Shattock said his team would develop the new vaccine technology as “a safety net to catch escaped mutations, reach variants that other vaccines may not, and meet potential needs for annual booster vaccinations.”

The Imperial vaccine uses the same design as the Moderna and Pfizer/BioNTech jabs. It employs self-amplifying RNA to force an immune reaction from the body, producing vital antibodies and T-cells that offer protection.

The vaccine’s initial trials came last summer as scientists around the world raced to develop the first effective jab.

However, with the UK and many other countries successfully moving forward with mass vaccine rollouts, Imperial and other top teams have decided to change course.

The technology used in the Imperial jab can be adapted to target new variants and mutations of coronavirus. This could fast-track the development of updated vaccines as the pandemic worsens in some parts of the world.

The Imperial team has also found methods to store new RNA vaccines in standard refrigeration for months, where current vaccines require expensive ultra-low temperature storage.

Shattock said: “Imperial College is working with philanthropists, investors, government and industry partners to take this exciting technology further.”

The UK government will continue its support for Imperial’s self-amplifying RNA technology as part of its anti-coronavirus policy.

Prof. Alice Gast, president of Imperial, said: “The self-amplifying RNA vaccine has much to offer in the fight against coronavirus and other diseases.

“This exciting technology will help accelerate future vaccine production, providing the agility to defend against viral mutations, and protect current and future generations from pandemics.”


More Ghanaians are wearing a cultural outfit after their president was mocked

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More Ghanaians are wearing a cultural outfit after their president was mocked

ACCRA: On a busy street in central Accra, Clement Azaabire hangs neatly sewn fugu smocks on lines, the striped, multicolored fabrics swaying in the breeze. For 15 years, Azaabire has proudly sold the garment that is associated with his community in northern Ghana. Now, it’s the talk of town.
More Ghanaians are wearing the colorful traditional outfit with pride in a trend triggered by online mockery.
Ghana’s President John Dramani Mahama in early February visited Zambia wearing a fugu garment, prompting ridicule from some social media users. Ghanaians responded by defending what they felt was a rich cultural heritage, and Tourism Minister Abla Dzifa Gomashie took it a step further by declaring Wednesdays as “Fugu Day.”
Since the “Fugu Day” declaration on Feb. 10, more people are wearing the smock to work on Wednesdays, but also on other days. And traders like Azaabire are selling out their stock.
“It makes me feel connected to where I come from,” said Wango Abdul Karim, a businessman who wears fugu to work every Wednesday.
Ghana is known for its rich textiles and weaving tradition

In Ghana, which is widely known for its rich fashion style and an agelong weaving heritage, traditional production of smock weaves has been the preserve of the north and an art skill handed down through generations.
The fugu smock, however, gained more prominence in March 1957 when Ghana’s first President Kwame Nkrumah wore it during the country’s inaugural independence ceremony. Today, it’s worn at festivals, state functions and increasingly in contemporary fashion.
Also known locally as batakari, the loose-fitting fugu smock is made from handwoven strips of cotton fabric stitched together to form a flowing robe, often worn over trousers and paired with a matching cap. The fabric is traditionally woven on narrow looms in Ghana’s northern savannah and sewn into distinctive styles, with the regional identifiers visible in its stripe patterns and in the number of stitch lines.
Scholars link its development to trade and migration across West Africa, including influences from Mossi and Hausa communities. Batakari, derived from the Hausa language, means “outer gown,” while fugu in the Mossi language means cloth. The smock has long represented prestige and is worn by chiefs, warriors and community leaders with certain designs reserved for special ceremonies.
At the Accra Arts and Crafts Center, Moses Adibasa guides strips of woven fabric through a sewing machine, pausing to align the narrow bands by hand before stitching them together.
He has earned a living from making traditional smocks for nearly two decades and is optimistic about the ripple effects of “Fugu Day.”
“It will benefit those selling thread, those weaving and those of us sewing,” Adibasa said.
Turning fugu into modern designs
In a studio in Accra, Perfectual Linnan, a fashion designer and founder of Roots by Linnan, recreates the fugu fabric into jackets, trousers and tops designed for everyday wear. She is part of a growing movement of young designers incorporating the fabric into modern designs.
“We want to show that you can wear the northern fabric in different ways,” she said. “If you’re not into the traditional smock, you can still carry a piece of culture with you.”
Although traditional looms are still used for the clothing, many weavers now rely on imported yarn due to the lack of locally grown cotton.
The “Fugu Day” celebration has meant higher demand and more pressure on the smock weavers, many of whom are struggling to increase production, according to Abigail Naki Gabor, secretary of Ghana’s smock weavers and sellers association.
One way to help is through increased government investments, said Gabor. “Using our hands slows the process and limits our ability to be productive. We need industrial machines,” she said.
Beyond the “Fugu Day,” Ghana is engineering a broader “Wear Ghana” campaign to promote local fashion and heritage with upcoming trade exhibitions planned, according to Kofi Atta Kakra Kusi with the Ghana Tourism Authority.
Back in her studio in Accra, Linnan is sounding an alarm about handling the smock with care despite the labor intensive process of weaving it.
“It is a careful, intentional process,” she says. “If we treat it only as a commodity and not as heritage, we lose something important.”