Philippines suspends world-first dengue vaccine

Sanofi had initially said its Dengvaxia vaccine was “critical” in the fight against dengue, the world’s most common mosquito-borne virus. (AFP)
Updated 01 December 2017
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Philippines suspends world-first dengue vaccine

MANILA: The Philippines said Friday it had suspended use of a landmark vaccine for the potentially deadly dengue virus after its manufacturer warned it could worsen the disease in some cases.
French pharmaceutical giant Sanofi announced Wednesday that its world-first dengue vaccine could lead to more severe symptoms for people who had not previously been infected.
The Philippines has vaccinated more than 700,000 children with Dengvaxia since 2016 when it became the first country to start using it on a mass scale.
But it said Friday the program had been suspended.
“In the light of this new analysis, the DOH (Department of Health) will place the dengue vaccination program on hold while review and consultation is ongoing with experts, key stakeholders, and the WHO (World Health Organization),” a government statement said.
Sanofi had initially said its Dengvaxia vaccine was “critical” in the fight against dengue, the world’s most common mosquito-borne virus.
It said Wednesday that a new study has confirmed Dengvaxia’s benefits for “those who had prior infection.”
“For those not previously infected by dengue virus, however, the analysis found that in the longer term, more cases of severe disease could occur following vaccination upon a subsequent dengue infection,” Sanofi said.
The Philippine government stressed it had not yet received reports of any problems with Dengvaxia.
“Currently, there is no reported case of severe dengue infection among those who received the vaccine,” its statement said.
More than 1,000 people in the Philippines died from dengue last year, out of 211,000 suspected cases, according to the government.


Iran war unsettles India’s packaged water makers as bottles, caps get pricey

Updated 55 min 10 sec ago
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Iran war unsettles India’s packaged water makers as bottles, caps get pricey

  • Higher polymer ‌prices hurt bottled water industry
  • Industry worth $5 billion has big multinational players like Pepsi, Coca-Cola

NEW ​DELHI: The Iran war is rattling India’s $5 billion packaged water market just ahead of the sweltering summer season.
One of the world’s fastest growing bottled water markets is seeing some manufacturers hike prices for distributors, as supply disruptions linked to the war fuel higher costs in everything from plastic bottles to caps, labels and cardboard boxes.
Though retail prices are yet to feel the heat and bigger companies are absorbing the pain, about 2,000 smaller bottled water makers have increased rates for their resellers by around 1 rupee per ‌bottle, a ‌5 percent hike, which will rise by a further 10 percent in ​coming ‌days, ⁠according ​to the ⁠Federation of All India Packaged Drinking Water Manufacturers’ Association.
Consumers usually pay less than 20 rupees, or around 20 US cents, for a one-liter bottle.
“There is chaos and within the next 4-5 days, this will start impacting customer prices,” said Apurva Doshi, the federation’s secretary general.
Rising oil prices have increased the cost of polymer, which is made from crude oil and is a key material for the industry’s plastic bottles. The cost of material used in making ⁠plastic bottles has risen by 50 percent to 170 rupees per kilogram, ‌while the price of the caps has more than ‌doubled to 0.45 rupees apiece. Even corrugated boxes, labels and ​adhesive tape are costing much more, ‌industry letters showed.
Clean water is a privilege in the country of 1.4 billion people where ‌researchers say 70 percent of the groundwater is contaminated, leaving people reliant on bottled water. Companies including Bisleri, Coca-Cola’s Kinley, Pepsi’s Aquafina, billionaire Mukesh Ambani’s Reliance and Tata all compete for a share of the $5 billion market. The companies did not respond to Reuters request for comment.
PREMIUM WATER FACES HEAT ‌TOO
Within the broad bottled water market, natural mineral water is a $400 million business in India and a new, fast-growing wellness product for ⁠India’s wealthy.
The premium ⁠water segment accounted for 8 percent of the bottled water market last year in India, compared to just 1 percent in 2021, Euromonitor says.
Aava, which sells mineral water sourced from the foothills of the Aravalli mountains, has increased prices of its water bottles by 18 percent for resellers, Shiroy Mehta, CEO of the company, told Reuters.
“Most manufacturers are absorbing 40-50 percent of the cost to ensure that they don’t lose clients. It’s a poor situation for the beverage industry ahead of the summer season,” he said.
The mass market, however, is dominated by companies that produce “drinking water” to be sold in 1-liter bottles to customers. Clear Premium Water, a brand of India’s Energy Beverages, said in a notice to its distributors there ​had been an “unprecedented and continuous surge” in ​prices of key raw materials used in packaging and production.
“It is no longer possible for us to absorb the escalating costs while maintaining existing product prices,” the notice said.