WASHINGTON: The most widely used COVID-19 vaccines may offer a surprise benefit for some cancer patients – revving up their immune systems to help fight tumors.
People with advanced lung or skin cancer who were taking certain immunotherapy drugs lived substantially longer if they also got a Pfizer or Moderna shot within 100 days of starting treatment, according to preliminary research being reported Wednesday in the journal Nature.
And it had nothing to do with virus infections.
Instead, the molecule that powers those specific vaccines, mRNA, appears to help the immune system respond better to the cutting-edge cancer treatment, concluded researchers from MD Anderson Cancer Center in Houston and the University of Florida.
The vaccine “acts like a siren to activate immune cells throughout the body,” said lead researcher Dr. Adam Grippin of MD Anderson. “We’re sensitizing immune-resistant tumors to immune therapy.”
Health Secretary Robert F. Kennedy Jr. has raised skepticism about mRNA vaccines, cutting $500 million in funding for some uses of the technology.
But this research team found its results so promising that it is preparing a more rigorous study to see if mRNA coronavirus vaccines should be paired with cancer drugs called checkpoint inhibitors — an interim step while it designs new mRNA vaccines for use in cancer.
A healthy immune system often kills cancer cells before they become a threat. But some tumors evolve to hide from immune attack. Checkpoint inhibitors remove that cloak. It’s a powerful treatment – when it works. Some people’s immune cells still don’t recognize the tumor.
Messenger RNA, or mRNA, is naturally found in every cell and it contains genetic instructions for our bodies to make proteins. While best known as the Nobel Prize-winning technology behind COVID-19 vaccines, scientists have long been trying to create personalized mRNA “treatment vaccines” that train immune cells to spot unique features of a patient’s tumor.
The new research offers “a very good clue” that maybe an off-the-shelf approach could work, said Dr. Jeff Coller, an mRNA specialist at Johns Hopkins University who wasn’t involved with the work. “What it shows is that mRNA medicines are continuing to surprise us in how beneficial they can be to human health.”
Grippin and his Florida colleagues had been developing personalized mRNA cancer vaccines when they realized that even one created without a specific target appeared to spur similar immune activity against cancer.
Grippin wondered if the already widely available mRNA coronavirus shots might also have some effect, too.
So the team analyzed records of nearly 1,000 advanced cancer patients undergoing checkpoint inhibitor treatment at MD Anderson – comparing those who happened to get a Pfizer or Moderna shot with those who didn’t.
Vaccinated lung cancer patients were nearly twice as likely to be alive three years after beginning cancer treatment as the unvaccinated patients. Among melanoma patients, median survival was significantly longer for vaccinated patients – but exactly how much isn’t clear, as some of that group were still alive when the data was analyzed.
Non-mRNA vaccines such as flu shots didn’t make a difference, he said.
COVID-19 vaccines may help some cancer patients fight tumors
https://arab.news/v3skp
COVID-19 vaccines may help some cancer patients fight tumors
- A healthy immune system often kills cancer cells before they become a threat
Russia says foreign forces in Ukraine would be ‘legitimate targets’
- Moscow has repeatedly said it will not tolerate the presence in Ukraine of troops from Western countries
MOSCOW: Russia would regard the deployment of any foreign military forces or infrastructure in Ukraine as foreign intervention and treat those forces as legitimate targets, the Foreign Ministry said on Monday, citing Minister Sergei Lavrov.
The ministry’s comment, one of many it said were in response to questions put to Lavrov, also praised US President Donald Trump’s efforts at working for a resolution of the war and said he understood the fundamental reasons behind the conflict.
“The deployment of military units, facilities, warehouses, and other infrastructure of Western countries in Ukraine is unacceptable to us and will be regarded as foreign intervention posing a direct threat to Russia’s security,” the ministry said on its website.
It said Western countries — which have discussed a possible deployment to Ukraine to help secure any peace deal — had to understand “that all foreign military contingents, including German ones, if deployed in Ukraine, will become legitimate targets for the Russian Armed Forces.”
The United States has spearheaded efforts to hold talks aimed at ending the conflict in Ukraine and a second three-sided meeting with Russian and Ukrainian representatives is to take place this week in the United Arab Emirates.
The issue of ceding internationally recognized Ukrainian territory to Russia remains a major stumbling block. Kyiv rejects Russian calls for it to give up all of its Donbas region, including territory Moscow’s forces have not captured.
Moscow has repeatedly said it will not tolerate the presence in Ukraine of troops from Western countries.
The ministry said Moscow valued the “purposeful efforts” of the Trump administration in working toward a resolution and understanding Russia’s long-running concerns about NATO’s eastward expansion and its overtures to Ukraine.
It described Trump as “one of the few Western politicians who not only immediately refused to advance meaningless and destructive preconditions for starting a substantive dialogue with Moscow on the Ukrainian crisis, but also publicly spoke about its root causes.”
