WASHINGTON: The most widely used COVID-19 vaccines may offer a surprise benefit for some cancer patients – revving up their immune systems to help fight tumors.
People with advanced lung or skin cancer who were taking certain immunotherapy drugs lived substantially longer if they also got a Pfizer or Moderna shot within 100 days of starting treatment, according to preliminary research being reported Wednesday in the journal Nature.
And it had nothing to do with virus infections.
Instead, the molecule that powers those specific vaccines, mRNA, appears to help the immune system respond better to the cutting-edge cancer treatment, concluded researchers from MD Anderson Cancer Center in Houston and the University of Florida.
The vaccine “acts like a siren to activate immune cells throughout the body,” said lead researcher Dr. Adam Grippin of MD Anderson. “We’re sensitizing immune-resistant tumors to immune therapy.”
Health Secretary Robert F. Kennedy Jr. has raised skepticism about mRNA vaccines, cutting $500 million in funding for some uses of the technology.
But this research team found its results so promising that it is preparing a more rigorous study to see if mRNA coronavirus vaccines should be paired with cancer drugs called checkpoint inhibitors — an interim step while it designs new mRNA vaccines for use in cancer.
A healthy immune system often kills cancer cells before they become a threat. But some tumors evolve to hide from immune attack. Checkpoint inhibitors remove that cloak. It’s a powerful treatment – when it works. Some people’s immune cells still don’t recognize the tumor.
Messenger RNA, or mRNA, is naturally found in every cell and it contains genetic instructions for our bodies to make proteins. While best known as the Nobel Prize-winning technology behind COVID-19 vaccines, scientists have long been trying to create personalized mRNA “treatment vaccines” that train immune cells to spot unique features of a patient’s tumor.
The new research offers “a very good clue” that maybe an off-the-shelf approach could work, said Dr. Jeff Coller, an mRNA specialist at Johns Hopkins University who wasn’t involved with the work. “What it shows is that mRNA medicines are continuing to surprise us in how beneficial they can be to human health.”
Grippin and his Florida colleagues had been developing personalized mRNA cancer vaccines when they realized that even one created without a specific target appeared to spur similar immune activity against cancer.
Grippin wondered if the already widely available mRNA coronavirus shots might also have some effect, too.
So the team analyzed records of nearly 1,000 advanced cancer patients undergoing checkpoint inhibitor treatment at MD Anderson – comparing those who happened to get a Pfizer or Moderna shot with those who didn’t.
Vaccinated lung cancer patients were nearly twice as likely to be alive three years after beginning cancer treatment as the unvaccinated patients. Among melanoma patients, median survival was significantly longer for vaccinated patients – but exactly how much isn’t clear, as some of that group were still alive when the data was analyzed.
Non-mRNA vaccines such as flu shots didn’t make a difference, he said.
COVID-19 vaccines may help some cancer patients fight tumors
https://arab.news/v3skp
COVID-19 vaccines may help some cancer patients fight tumors
- A healthy immune system often kills cancer cells before they become a threat
US, Ukraine officials say they’ll meet for 3rd day after progress on creating a security framework
- Witkoff and Kushner’s talks in Florida with Umerov, Ukraine’s lead negotiator, and Hnatov follow discussions between President Vladimir Putin and the US envoys at the Kremlin on Tuesday
WASHINGTON: President Donald Trump’s advisers and Ukrainian officials say they’ll meet for a third day of talks on Saturday after making progress on finding agreement on a security framework for postwar Ukraine.
The two sides also offered the sober assessment that any “real progress toward any agreement” ultimately will depend “on Russia’s readiness to show serious commitment to long-term peace.”
The statement from US special envoy Steve Witkoff, Trump’s son-in-law Jared Kushner as well as Ukrainian negotiators Rustem Umerov and Andriy Hnatov came after they met for a second day in Florida on Friday. They offered only broad brushstrokes about the progress they say has been made as Trump pushes Kyiv and Moscow to agree to a US-mediated proposal to end nearly four years of war.
“Both parties agreed that real progress toward any agreement depends on Russia’s readiness to show serious commitment to long-term peace, including steps toward de-escalation and cessation of killings,” the statement said. “Parties also separately reviewed the future prosperity agenda which aims to support Ukraine’s post-war reconstruction, joint US–Ukraine economic initiatives, and long-term recovery projects.”
The US and Ukrainian officials also discussed “deterrence capabilities” that Ukraine will need “to sustain a lasting peace.”
Witkoff and Kushner’s talks in Florida with Umerov, Ukraine’s lead negotiator, and Hnatov follow discussions between President Vladimir Putin and the US envoys at the Kremlin on Tuesday.
Friday’s session took place at the the Shell Bay Club in Hallandale Beach, a high-end private golf and lifestyle destination owned by Witkoff’s real estate development company.
Previous diplomatic attempts to break the deadlock have come to nothing and the war has continued unabated. Officials largely have kept a lid on how the latest talks are going, though Trump’s initial 28-point plan was leaked.
Ukrainian President Volodymyr Zelensky said his country’s delegation in Florida wanted to hear from the US side about the talks at the Kremlin.
Zelensky, as well as European leaders backing him, have repeatedly accused Putin of stalling in peace talks while the Russian army tries to press forward with its invasion. Zelensky said in a video address late Thursday that officials wanted to know “what other pretexts Putin has come up with to drag out the war and to pressure Ukraine.”
Speaking to Russian journalist Pavel Zarubin on Friday, Kremlin foreign affairs adviser Yuri Ushakov praised Kushner as potentially playing an important role in ending Russia’s invasion of Ukraine. Ushakov also took part in Tuesday’s talks at the Kremlin.
“If any plan leading to a settlement is put on paper, it will be the pen of Mr. Kushner that will lead the way,” Ushakov said.
The flattering comments about Kushner by the senior Russian official come as Putin has sought to sow division between Trump and Ukraine and Europe at a moment when Trump’s impatience with the conflict is mounting. Putin said his five-hour talks this week with Witkoff and Kushner were “necessary” and “useful,” but some proposals were unacceptable.
Kushner, who is married to Trump’s daughter Ivanka, was a senior adviser to Trump during his first term and was the president’s point person on developing the Abraham Accords, which formalized commercial and diplomatic ties between Israel and a trio of Arab nations.
Kushner has played a more informal role in Trump’s second go-around, but he helped Witkoff close out ceasefire and hostage negotiations between Israel and Hamas this fall. Trump tapped Kushner again to pair up with Witkoff to try to find an endgame to Russia’s invasion of Ukraine.
The European take on the peace talks
Ushakov, who accompanied Putin on a visit to India on Friday, repeated the Russian president’s recent criticism of Europe’s stance on the peace talks. Kyiv’s European allies are concerned about possible Russian aggression beyond Ukraine and want a prospective peace deal to include strong security guarantees.
Kyiv’s allies in Europe are “constantly putting forward demands that are unacceptable to Moscow,” Ushakov told Russia’s state-owned Zvezda TV. “Putting it mildly, the Europeans don’t help Washington and Moscow reach a settlement on the Ukrainian issues.”
French President Emmanuel Macron said Friday that he made progress during a visit to Beijing on getting Chinese leader Xi Jinping’s support for peace efforts.
“We exchanged deeply and truthfully on all points, and I saw a willingness from the (Chinese) president to contribute to stability and peace,” Macron said.
The French president said he stressed that Ukraine needs guarantees that Russia won’t attack it again if a settlement is reached and that Europe must have a voice in negotiations.
“The unity between Americans and Europeans on the Ukrainian issue is essential. And I say it, repeat it, emphasize it. We need to work together,” Macron said.
The latest drone attacks
Russian drones struck a house in central Ukraine, killing a 12-year-old boy, officials said, while long-range Ukrainian strikes reportedly targeted a Russian port and an oil refinery.
The Russian attack on Thursday night in Ukraine’s central Dnipropetrovsk region destroyed the house where the boy was killed and also two women were injured, according to the head of the regional military administration, Vladyslav Haivanenko.
The Ukrainian air force said Russia fired 137 drones of various types during the night.
Ukrainian drones attacked a port and an oil refinery inside Russia overnight as part of Kyiv’s campaign to disrupt Russian logistics, Ukraine’s general staff said.
The drones struck Temriuk sea port in Russia’s Krasnodar region and the Syzran oil refinery in the Samara region, starting blazes, a statement said. Syzran is about 800 kilometers (500 miles) east of the border with Ukraine.
The Russian Defense Ministry said only that its air defenses intercepted 85 Ukrainian drones over Russian regions and Crimea, which Russia illegally annexed in 2014.
