Researchers pin hopes on pan-coronavirus vaccine to end the pandemic

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Medics carry out COVID-19 vaccinations during a mass campaign in the Bneid Al-Gar district of Kuwait City on October 11, 2021. (AFP)
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Updated 01 February 2022
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Researchers pin hopes on pan-coronavirus vaccine to end the pandemic

  • Current vaccines have reduced the severity of COVID-19 symptoms, but emerging variants remain a challenge 
  • A pan-coronavirus vaccine could be a game-changer, but only if the global distribution gap is addressed

DUBAI: When a handful of pharmaceutical firms began the roll-out of COVID-19 vaccines in early 2021, many thought the worst of the pandemic was over. Indeed, the idea of a tangible weapon against the virus that had killed millions and devastated economies worldwide was temporarily empowering.

Within months, a selection of vaccines hit the market, with countries racing to secure enough doses for their populations in the hope of preventing further disruption. More than 9 billion doses later, with about half the global population “fully vaccinated,” it seemed as though the tide was finally turning against the virus and that normal life could soon resume.

 

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Sadly, such optimism would prove short-lived. Although the vaccine roll-out reduced the severity of COVID-19 symptoms, alleviating pressure on hospitals and saving many lives, scientists have struggled to contain mutations of the virus, including the latest highly transmissible omicron variant, which has broken through the vaccine shield.

This has forced pharmaceutical firms to return to the drawing board to consider variant-specific vaccines, an extended booster program to prolong immunity, or even “universal” vaccines that can tackle every variant of the virus. Such a pan-coronavirus vaccine could become publicly available in the not too distant future.




Emmanuel Kouvousis

“I believe a fourth (omicron specific) dose could become available in another six to nine months, as long as the omicron variant is dominant,” Emmanuel Kouvousis, a senior scientific adviser at Vesta Care, told Arab News. “However, if another more disruptive variant emerges, then we need to consider a scenario where we get a booster shot every three months.”

Kouvousis says a change in seasons could help delay the emergence of a new variant as the spread of the virus tends to slow in the spring and summer months. This could offer scientists a window of opportunity to get ahead of new variants.

“Many people ask if there will be a solution to this pandemic, and I say absolutely,” Kouvousis said. “There is huge hope that this pandemic will end, firstly because billions of people have been vaccinated and many others have been persuaded that the only way out of this is through vaccines, and secondly, because of a pan-COVID or ‘universal’ vaccine, which is currently in the testing phase.”




With billions of people already vaccinated, it is hoped that the COVID-19 pandemic will end. (AFP file photo)

Last year, the US National Institute of Allergy and Infectious Diseases awarded $36.3 million to three academic institutions — Duke University, the University of Wisconsin, and Boston’s Brigham and Women’s Hospital — to research and develop universal vaccines.

“We want a pan-coronavirus vaccine so that you have it on the shelf to respond to the next viral pandemic,” Anthony Fauci, the White House chief medical adviser, told NBC in January.

Separately, he told a Senate committee the development of a universal coronavirus vaccine could help the world tackle the next pandemic. “There’s a lot of investment, not only in improving the vaccines that we have for SARS-CoV-2, but a lot of work ... to develop the next generation of vaccines, particularly universal coronavirus vaccines,” he said at the hearing.

Among the scientists working on the vaccine are a team at the Walter Reed Army Institute of Research. Reporting promising results in animals, their version of the universal vaccine is known as the SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) vaccine, currently in phase 1 of human trials.

So far, the three-dose vaccine has been tested with two jabs 28 days apart followed by a third shot six months later. Kayvon Modjarrad, co-inventor of SpFN, said in a press statement that the new vaccine uses a harmless portion of the COVID-19 virus to build up the body’s defenses.

This method follows the same used in developing universal flu vaccines, an approach that is different to that used in three of the most popular COVID-19 vaccines today.  





COVID-19 has proved to be tougher than earlier thought, mutating into numerous variants as vaccine experts try to suppress it. (AFP file photo)

Vaccines produced by Pfizer and Moderna use messenger RNA (mRNA) to teach cells how to make a protein that will trigger an immune response inside the body, thereby building immunity. Meanwhile, others like the Johnson & Johnson vaccine use a harmless rhinovirus to train the immune system to respond to COVID-19.

Despite the huge progress made in vaccine production and distribution over the past year, the coronavirus, with its ever-growing family of variants, all named after letters of the Greek alphabet, continues to defy efforts to find the proverbial silver bullet.

Confidence among the fully vaccinated plummeted in the run-up to the winter holidays after the World Health Organization named omicron a variant of concern. It went on to infect a record number of people within a matter of days, pushing many countries to reimpose containment measures.




As COVID-19 continues to defy international efforts to put it under control, booster shots are being widely administered to maintain immunity. (AFP file photo)

Soon, millions of vaccinated people were informed that they would need a third or even a fourth dose to avoid becoming seriously ill. Even people who have already had the virus have been reinfected with the new variant.

Some countries, such as the UK, are working toward herd immunity, lifting almost all restrictions on travel and public spaces. However, Kouvousis is skeptical that herd immunity can be achieved through mass infection.

“It can only come about through vaccinations and having 90 percent of the world’s population fully vaccinated within a reasonable time span in order to avoid the emergence of new mutations,” he said.

In the meantime, booster shots are being widely administered in developed countries to maintain immunity. But even with a booster, experts say that the public should continue to follow hygiene and social distancing advice.

“The key after getting a booster shot is to wear the mask properly, which very few people do,” Dr. Gregory Poland, founder of the Mayo Clinic’s Vaccine Research Group, told Arab News. “The vaccines we have are predominantly disease-blocking and less so infection-blocking.”




Dr. Gregory Poland, founder of the Mayo Clinic’s Vaccine Research Group.

Part of the reason why developing nations are so far behind with the roll-out is the continuing monopolization of vaccine production and distribution by a few key players: AstraZeneca, BioNTech, Johnson & Johnson, Moderna, Novavax and Pfizer.

Just 10 percent of the African continent is currently immunized against the virus, leaving a gap for future dominant mutations to arise in these countries. Experts such as Poland want pharmaceutical firms to suspend their patents and share their vaccine formulas with smaller regional outfits, allowing them to produce shots closer to the point of need.

“This is a potentially important strategy,” he said. “Each sovereign nation gets to decide how to organize itself and protect its people. This includes national production facilities of those items critical to the well-being of the population or viable partnerships with other producers of the goods they need.”

To try and meet local demand and bridge the gap, several countries are working on their own generic vaccines and drugs to fight the virus. For instance, India’s first mRNA-based COVID-19 vaccine “HGCO19” aims to offer protection against omicron specifically.

The vaccine, developed by Gennova Biopharmaceuticals Ltd., is set to begin human trials in the near future after early studies found the vaccine to be “safe, tolerable and immunogenic.” Similarly, Egypt’s first coronavirus vaccine, called “COVI-VAX,” is in the testing phase.

Meanwhile, the Philippines, which has one of Asia’s lowest vaccination rates, has authorized the use of a recombinant vaccine called “ReCOV” developed in China by Jiangsu Recbio Technology Co., as the country lacks the capacity to develop one of its own.




A Filipino resident receives a booster jab in Manila on Jan. 27, 2022 amidst rising COVID-19 infections driven by Omicron variant. (Maria Tan / AFP) 

While still in its second phase of clinical trials, preliminary studies show that ReCOV has a sufficient neutralization effect on COVID-19 variants such as omicron and its earlier delta iteration.

Distribution has also been a major issue for hard-to-reach communities in the developing world. Shipping firms such as DHL have played a pivotal role in delivering vaccines, carting some 1.85 billion doses to 174 countries to date. But unless local authorities handle the cargo correctly on arrival, shots can be wasted.

“Vaccines are high value, extremely sensitive, and temperature-controlled items,” Fatima Ait Bendawad, head of DHL Global Humanitarian Logistics Competency Center in Dubai, told Arab News. “Any misstep in the logistics chain would result in potential loss of lives because the vulnerable can’t get to them on time.”

For Kouvousis, the problem is not entirely confined to the matter of production or distribution. In many cases, vaccination campaigns have proved slow or ineffective owing to the poor state of medical institutions in developing nations.

“The major players have the infrastructure to produce what is needed for the whole world,” Kouvousis said. “But some countries don’t have the infrastructure, the facilities or the education to use them effectively.”

After two years of ups and downs in the fight against the pandemic, the emergence of a pan-coronavirus vaccine would be a global game-changer. However, unless production and distribution are streamlined and enough people are administered shots in a short space of time, the opportunity to end the pandemic this year could yet be missed.


New humanitarian crisis looms in Afghanistan as Pakistan forces refugees to return

Updated 47 min 11 sec ago
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New humanitarian crisis looms in Afghanistan as Pakistan forces refugees to return

  • Mass deportation coincides with huge foreign aid cuts under new US policies
  • Deadline for hundreds of thousands of Afghans to leave Pakistan was March 31

KABUL: Pakistan’s plan to expel most of its Afghan refugees this year will trigger a new humanitarian crisis in Afghanistan, aid groups warn, as foreign funding has been slashed and existing infrastructure is inadequate to support returnees.

Pakistan is home to about 3 million Afghans, many of whom fled their country during decades of war. This number includes Afghans born in Pakistan, as well as those who sought shelter after the Taliban returned to power in 2021.

They are the main group facing deportation under the Pakistani government’s nationwide crackdown to force out foreigners living in the country illegally. The drive also includes Afghan Citizen Card holders, who were given a deadline to leave by March 31. Pakistani authorities confirmed last week they were not extending the deadline.

According to UN data, 800,000 people with Afghan Citizen Cards and 1 million undocumented Afghans are currently set to be expelled. Since the launch of the crackdown in 2023, more than 843,000 Afghans have returned to their homeland.

“If they come in hundreds of thousands or millions, it will create another crisis in the country,” Abdul Fatah Jawad, director of Ehsas Welfare and Social Services Organization, told Arab News.

“Finding houses, jobs, and educational opportunities will be very difficult for this huge number of returnees. Health is another challenge.”

Over the past two months, more than 200 health facilities across Afghanistan have been either suspended or closed, and another 200 will shut by June due to external funding shortfalls, which come amid massive US aid cuts under the Donald Trump administration.

The US, which invaded Afghanistan in 2001, was its largest aid donor. It has been cutting its support since 2021. Washington withdrew its troops from Afghanistan after the collapse of its Western-backed regime and imposed sanctions on the country’s new rulers. It also froze all projects after spending billions on two decades of military and development operations.

The moves led to Afghanistan’s economic collapse and the disruption of basic services such as healthcare, education, and food distribution. Millions of people were left without essential support due to the collapse of institutions and infrastructure.

As the economy continues to reel and new aid cuts are implemented, the return of refugees will place an additional strain on a system that may not be able to bear it.

“With the overall shortage of donors’ financial aid, especially after the recent US funding cuts, Afghanistan is not prepared to receive large numbers of returnees at once and provide them with housing and livelihood facilities. This is a significant challenge and will certainly exacerbate the ongoing crisis in the country,” said Fareed-ud-Din Noori, country director of Women for Afghan Women, a US-based organization that has been providing shelter, protection and food services to returnees.

“Several international and national organizations that provided critical services to returnees in resettlement and reintegration areas in the country were forced to either close their offices or suspend their projects due to unavailability of funds.”

The prospect of immediately finding jobs for hundreds of thousands of families is unlikely.

“With unemployment levels skyrocketing across the country and livelihood prospects looking grim, these returnees will face significant challenges in starting a new life in the country. Afghanistan’s aid-dependent economy will come under increasing pressure,” Noori said.

“The international community’s financial support is compulsory to enable a proper response to the influx of returnees.”

The Afghan government, too, does not have a clear plan of how to handle the number of returning nationals and integrate them with the rest of the society. Its Refugee and Repatriation Minister Mawlawi Abdul Kabir said last month that Afghanistan would encourage its nationals to come back to the country, but they should be given time and return “according to an organized and gradual mechanism instead of forced deportation.”

Dr. Tayeb Khan, economist and lecturer at Kateb University in Kabul, warned that refugee children in particular will be affected by the forced migration.

“All of this is putting increasing pressure on the country’s fragile economy, leading to greater dependence on humanitarian aid and deepening the poverty situation. The government alone will not be able to integrate children of these returnees into schools and provide them with essential health services,” he said.

“Most of these refugees have established their own lives and businesses over the years they have lived abroad … When they are forced to return to Afghanistan against their will, they will struggle with finding a job or work at first. Tens of thousands of people in the country are already finding it very difficult to get employed, especially after development projects were suspended following the withdrawal of international funding from Afghanistan.”


Police summon US scholar in Thailand after army alleges he insulted the monarchy

Updated 04 April 2025
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Police summon US scholar in Thailand after army alleges he insulted the monarchy

  • A copy of the police summons says the regional army command filed charges against Chambers, including violating the law against defaming the monarchy
  • The 3rd Army Area, covering Thailand’s northern region, was named as the plaintiff in the document

BANGKOK: The Thai army has filed a criminal complaint against an American scholar working in Thailand, alleging that he insulted the country’s monarchy, an offense punishable by up to 15 years in prison.
Paul Chambers, a political science lecturer, said police came to his workplace at Naresuan University in the northern province of Phitsanulok on Friday morning to serve him with an arrest warrant and summoning him to the local police station to formally hear the charges.
Chambers said he will report himself on Tuesday and hopes to get released on bail.
“I’m basically in limbo because I can’t go anywhere. I’m not supposed to,” he told The Associated Press. “I don’t know what’s going to happen, but I’m kind of nervous.”
A copy of the police summons, seen by the AP, says the regional army command filed charges against Chambers, including violating the law against defaming the monarchy and the Computer Crime Act.


The letter, signed by Phitsanulok City police chief Watcharapong Sitthirungroj, said the warrant was approved by the Phitsanulok Provincial Court on March 31. Watcharapong denied any knowledge of the charges against Chambers when first reached by the AP, but when asked about his signature on the document, said he couldn’t immediately comment and asked a reporter to call back.
The 3rd Army Area, covering Thailand’s northern region, was named as the plaintiff in the document, but could not be reached for comment. Army spokesperson Winthai Suvaree could not immediately be reached.
The summons did not explain the details of the offense that Chambers was accused of. Chambers said he believes it was related to a webinar last October in which he discussed the influence of the military in Thai politics.
Thailand’s lese majeste law calls for three to 15 years’ imprisonment for anyone who defames, insults or threatens the king, the queen, the heir apparent or the regent.
Critics say it is among the harshest such laws anywhere and has been used in Thailand to punish critics of the government and institutions such as the military. The army plays a major role in politics and has staged 13 successful coups since Thailand became a constitutional monarchy in 1932, most recently just 11 years ago.
It is rare for a foreigner to be charged under the law, which has been applied frequently in the past decade during a period of political polarization.
Public criticism of the monarchy, a linchpin of Thai identity, used to be rare, but student-led pro-democracy protests began to challenge that taboo in 2020, openly criticizing the institution. That led to vigorous prosecutions under what was previously a little-used law.
The advocacy group Thai Lawyers for Human Rights has said that since early 2020, more than 270 people — many of them student activists — have been charged with violating the lese majeste law, often referred to as Article 112.


Everything I did was for my country, Duterte says via daughter

Updated 04 April 2025
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Everything I did was for my country, Duterte says via daughter

  • “Everything I did, I did for my country. (I don’t know) whether that statement is acceptable or not, but I want it out to the world,” said Sara, relaying her father’s words
  • The vice president would not be drawn as to whether this amounted to an admission of responsibility for the crimes her father is facing at the ICC

THE HAGUE: Philippine ex-president Rodrigo Duterte, facing International Criminal Court charges over his deadly narcotics crackdown, said “everything I did, I did for my country,” his daughter told reporters Friday.
Sara Duterte, who is also her country’s vice president, was briefing journalists at the detention center in The Hague after a long conversation with her father interned inside.
She also relayed that her father wants proceedings against him to move as quickly as possible, with the 80-year-old fearful of dying in custody.
“Everything I did, I did for my country. (I don’t know) whether that statement is acceptable or not, but I want it out to the world,” said Sara, relaying her father’s words.
The vice president would not be drawn as to whether this amounted to an admission of responsibility for the crimes her father is facing at the ICC.
It was the first reported comments from Rodrigo Duterte since he appeared tired and dazed at an initial appearance at the ICC, which he attended by videolink and barely spoke.
In a video posted when Duterte arrived in the Netherlands last month to face the charges, he had said “I will be responsible for all of this.”
Duterte stands accused of the crime against humanity of murder over his years-long campaign against drug users and dealers that rights groups said killed thousands.
In the prosecutor’s application for his arrest, he said Duterte’s alleged crimes were “part of a widespread and systematic attack directed against the civilian population in the Philippines.”
“Potentially tens of thousands of killings were perpetrated,” the prosecutor alleged of the campaign that targeted mostly poor men, often without proof they were linked to drugs.
In an interview with AFP earlier Friday, a lawyer for victims, Gilbert Andres, said loved-ones of those affected were seeking “truth and justice” from a potential trial.
The next hearing is scheduled for September 23, where the charges against him will be laid out, but Sara Duterte said her father was eager to get proceedings underway.
“He wants to go back to the Philippines. He said, ‘I am an old man. I can die anytime. But I want to die in my country’,” said Sara Duterte.


Turkiye says any Ukraine peace deal hard to digest — but better than more death

Updated 04 April 2025
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Turkiye says any Ukraine peace deal hard to digest — but better than more death

  • Fidan said Turkiye supported a US initiative to seek an end to the war in Ukraine
  • The sides remained a “little bit far away” from reaching a deal

BRUSSELS: Turkish Foreign Minister Hakan Fidan told Reuters on Friday that any potential peace agreement between Ukraine and Russia would be “difficult to digest” but would still be better than the alternative of more death and destruction.
Turkiye, a NATO member, has maintained cordial ties with both Kyiv and Moscow since Russia’s full-scale invasion of Ukraine in 2022. It has voiced support for Ukraine’s territorial integrity and provided it with military help, while opposing sanctions on Russia.
In an interview on the sidelines of a meeting of NATO foreign ministers in Brussels, Fidan said Turkiye supported a US initiative to seek an end to the war in Ukraine, but that the sides remained a “little bit far away” from reaching a deal.
“It will be extremely difficult to digest any proposal,” Fidan said. “But when we look at the other option, which is more death and destruction, I think whatever the conditions that we have... will be more reasonable” than the alternative.
US President Donald Trump “is finally following an agenda to stop the war,” he added.
Asked about potential security guarantees for Ukraine, Fidan said Europe could not provide them on its own without US support, but added that a deterrence factor was needed for the fighting not to restart.
“There is a huge effort to get the American side again to engage in security support to Ukraine,” he said, referring to recent talks among European states.
He added that “we should expect” that all sides including Russia would honor any ultimate agreement.
The prospect of ending the war has heightened Turkiye’s role in regional security, making it a key potential partner in the restructuring of Europe’s security architecture, as European powers scramble to bolster their own defenses and seek guarantees for Ukraine under any forthcoming peace deal.
Kyiv has said Turkiye, with the second largest army in NATO, would be an important guarantor for security. Ankara has said it would consider joining a peace initiative on the ground, though it has said details of such a mission remain unclear.
Fidan repeated Turkiye’s offer to host Russia and Ukraine for possible peace talks, after having hosted initial talks in 2022.

US SANCTIONS
Asked about Trump’s dramatic shift in US transatlantic security policies, including closer ties with Russia, Fidan said this could be an opportunity for Europe to be more independent after its “huge dependency” on the United States since the Cold War.
“If we see that the main actors are not hostile anymore (and are) having some kind of cooperation, I think the mentality that we have inherited from the Cold War, which was based on the hostility between mainly the United States and Russia will create a huge change,” he said.
Fidan, who met US Secretary of State Marco Rubio at the NATO summit after having visited him in Washington last month, also said he was hopeful that Trump would find a solution to end years-long US sanctions on Turkiye’s defense industry.
The so-called CAATSA sanctions were applied after Turkiye acquired Russian S-400 defense systems in 2019, also resulting in the country’s removal from an F-35 fighter jet development and procurement system.
The sanctions “should be corrected,” Fidan said. “I think Mr. Trump, with his problem-solving techniques and his team, will be able to come up with some sort of solution.”


China imposes a 34 percent tariff on imports of all US products starting April 10

Updated 04 April 2025
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China imposes a 34 percent tariff on imports of all US products starting April 10

  • The new tariff matches the rate of the US “reciprocal” tariff of 34 percent on Chinese exports that Trump ordered this week
  • China’s customs administration said it had suspended imports of chicken from some US suppliers after detected furazolidone

BANGKOK: China announced Friday that it will impose a 34 percent tariff on imports of all US products beginning April 10, part of a flurry of retaliatory measures following US President Donald Trump’s “Liberation Day” slate of double-digit tariffs.
The new tariff matches the rate of the US “reciprocal” tariff of 34 percent on Chinese exports that Trump ordered this week.
The Commerce Ministry in Beijing also said in a notice that it will impose more export controls on rare earths, which are materials used in high-tech products such as computer chips and electric vehicle batteries.
Included in the list of minerals subject to controls was samarium and its compounds, which are used in aerospace manufacturing and the defense sector. Another element called gadolinium is used in MRI scans.
China’s customs administration said it had suspended imports of chicken from some US suppliers after detected furazolidone, a drug banned in China, in shipments from those companies.
Separately, it said had found high levels of mold in the sorghum and salmonella in poultry meat from some of the companies. The announcements affect one company exporting sorghum, C&D Inc., and four poultry companies.
Additionally, the Chinese government said it had added 27 firms to lists of companies subject to trade sanctions or export controls.
Among them, 16 are subject to a ban on the export of “dual-use” goods. High Point Aerotechnologies, a defense tech company, and Universal Logistics Holding, a publicly traded transportation and logistics company, were among those listed.
Beijing also announced it filed a lawsuit with the World Trade Organization over the tariffs issue.
“The United States’ imposition of so-called ‘reciprocal tariffs’ seriously violates WTO rules, seriously damages the legitimate rights and interests of WTO members, and seriously undermines the rules-based multilateral trading system and international economic and trade order,” the Commerce Ministry said.
“It is a typical unilateral bullying practice that endangers the stability of the global economic and trade order. China firmly opposes this,” it said.
Other actions include the launch of an anti-monopoly investigation into DuPont China Group Co., a subsidiary of the multinational chemical giant, and an anti-dumping probe into X-ray tube and CT tubes for CT scanners imported from the US and India.
In February, China announced a 15 percent tariff on imports of coal and liquefied natural gas products from the US It separately added a 10 percent tariff on crude oil, agricultural machinery and large-engine cars.
Dozens of US companies are subject to controls on trade and investment, while many more Chinese companies face similar limits on dealings with US firms.
The latest tariffs apply to all products made in the US, according to a statement from the Ministry of Finance’s State Council Tariff Commission.
While friction on the trade front has been heating up, overall relations are somewhat less fractious.
US and Chinese military officials met this week for the first time Trump took office in January to shared concerns about military safety on the seas. The talks held Wednesday and Thursday in Shanghai were aimed at minimizing the risk of trouble, both sides said.