Can you mix and match COVID-19 vaccines?

The authorized COVID-19 shots around the world are all designed to stimulate your immune system to produce virus-fighting antibodies. (File/AFP)
Short Url
Updated 17 June 2021
Follow

Can you mix and match COVID-19 vaccines?

  • Scientists at Oxford University in the United Kingdom are testing combinations of the two-dose COVID-19 vaccines
  • So far, limited data suggests an AstraZeneca shot followed by the Pfizer shot is safe and effective

Can you mix and match two-dose COVID-19 (coronavirus) vaccines?

It’s likely safe and effective, but researchers are still gathering data to be sure.

The authorized COVID-19 shots around the world are all designed to stimulate your immune system to produce virus-fighting antibodies, though the way they do so varies, noted Dr. Kate O’Brien, director of the World Health Organization’s vaccine unit.

“Based on the basic principles of how vaccines work, we do think that the mix-and-match regimens are going to work,” she said.

Scientists at Oxford University in the United Kingdom are testing combinations of the two-dose COVID-19 vaccines made by AstraZeneca, Moderna, Novavax and Pfizer-BioNTech. Smaller trials are also ongoing in Spain and Germany.

“We really just need to get the evidence in each of these (vaccine) combinations,” O’Brien said.

So far, limited data suggests an AstraZeneca shot followed by the Pfizer shot is safe and effective. The combination also appears to come with a slightly higher likelihood of temporary side effects like aches and chills.

That might be because mixing and matching different types of vaccines can often produce a stronger immune response, said Lawrence Young, a virologist at the University of Warwick in the United Kingdom.

In some places, health officials already suggest mixing in select circumstances.

After the AstraZeneca vaccine was linked to extremely rare blood clots, many European countries including Germany, France and Spain recommended people who got it as a first dose get a Pfizer or Moderna shot as a second dose instead.

In Britain and Canada, officials say people should aim to get the same vaccine for their second dose if possible. If they got AstraZeneca as their first shot, they’re advised to get another vaccine only if they have a history of blood clots or other conditions that might put them at higher risk of clots.


France’s screen siren Brigitte Bardot dies at 91

Updated 5 sec ago
Follow

France’s screen siren Brigitte Bardot dies at 91

  • French PM Emmanuel Macron hails the actor as a legend who 'embodied a life of freedom'
  • Film star also courted controversy, embracing far-right views in her later years
PARIS: French film sensation Brigitte Bardot, a symbol of sexual liberation in the 1950s and 1960s who reinvented herself as an animal rights defender and embraced far-right views, died on Sunday aged 91, her foundation said.
She died in her Saint-Tropez home, La Madrague, on the French Riviera.
“The Brigitte Bardot Foundation announces with immense sadness the death of its founder and president, Madame Brigitte Bardot, a world-renowned actor and singer, who chose to abandon her prestigious career to dedicate her life and energy to animal welfare and her foundation,” it said in a statement sent to AFP.
The cause of death was not given. But Bardot was briefly hospitalized in October for what her office called a “minor” procedure. Bardot at the time had lambasted “idiot” Internet users for speculation that she had died.
Tributes were immediately paid to the star who was known as “BB” in her home country, with President Emmanuel Macron calling her a “legend” of the 20th century.
Born on September 28, 1934 in Paris, Bardot was raised in a well-off traditional Catholic household. Married four times, she had one child, Nicolas-Jacques Charrier, with her second husband, actor Jacques Charrier.
Bardot became a global star after appearing in “And God created Woman” in 1956, and went on to appear in about 50 more movies before giving up acting in 1973.
She turned her back on celebrity to look after abandoned animals, saying she was “sick of being beautiful every day.”

Far-right leanings

“With her films, her voice, her dazzling glory, her initials (BB), her sorrows, her generous passion for animals, and her face that became Marianne, Brigitte Bardot embodied a life of freedom,” Macron wrote on X, referring to the Marianne image used as the female symbol of the French republic.
His tribute, though, made no reference of Bardot’s alignment with far-right views in her post-cinema years, which alienated many of her fans.
Bardot was convicted five times for hate speech, mostly about Muslims, but also the inhabitants of the French island of Reunion whom she described as “savages.”
A supporter of far-right politician Marine Le Pen, Bardot declared herself “against the Islamization of France” in a 2003 book, citing “our ancestors, our grandfathers, our fathers have for centuries given their lives to push out successive invaders.”
The head of Le Pen’s far-right National Rally party, Jordan Bardella, was among the first to pay homage.
“Today the French people have lost the Marianne they so loved,” he wrote on X, calling her an “ardent patriot.”
Le Pen, who has been barred from public office pending an appeal trial in January, also paid tribute to Bardot as “incredibly French: free, untamable, whole.”
In her final book, Mon BBcedaire (“My BB Alphabet“), published weeks before her death, Bardot fired barbs at what she described as a “dull, sad, submissive” France and at her home town of Saint-Tropez, now packed with the wealthy tourists she helped attract.
The book also contained derogatory remarks about gay and transgender people.

Saint-Tropez retreat

After retiring from cinema, Bardot withdrew to her home in the Riviera resort of Saint-Tropez where she devoted herself to fighting for animals.
Her calling apparently came when she encountered a goat on the set of her final film, “The Edifying and Joyous Story of Colinot.” To save it from being killed, she bought the animal and kept it in her hotel room.
Bardot went on to found the Brigitte Bardot Foundation in 1986, which now has 70,000 donors and around 300 employees, according to its website.
“I’m very proud of the first chapter of my life,” she told AFP in a 2024 interview ahead of her 90th birthday.
“It gave me fame, and that fame allows me to protect animals — the only cause that truly matters to me.”
She added that she lived in “silent solitude” in her home “La Madrague,” surrounded by nature and content to be “fleeing humanity.”
On the subject of death, she warned that she wanted to avoid the presence of “a crowd of idiots” at her funeral and wished for a simple wooden cross above her grave, in her garden — the same as for her animals.