Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
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Updated 18 January 2021
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Long COVID could depend on severity of early infection: Study

  • ‘This finding could have major implications as to how the disease needs to be managed’

LONDON: The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study.

Researchers from Cambridge University studied 207 people who tested positive for COVID-19 over three months, finding that subjects with mild or no symptoms offered a rapid, strong immune response soon after infection.

The 207 people in the experiment ranged from asymptomatic healthcare workers to patients requiring ventilation. 

The team analyzed blood samples taken regularly over three months, and compared them with others taken from 45 healthy people.

The healthiest in the study produced anti-virus cells in larger numbers than the patients with severe COVID-19 infections. The first group also developed immunity cells within the first week of infection.

But the people with severe cases who required hospitalization were found to have an impaired immune response, which frustrated the body’s attempts to fight the virus, leading to more severe infection.

This weakened response to COVID-19 is characterized by inflammation of several organs, which starts right after a person catches the disease. 

Scientists say abnormalities in immune cells could explain the slower response to viral infection as well as the organ inflammation.

These two crucial factors could contribute to the severity of the disease and the phenomenon known as long COVID, where people feel symptoms and have health issues many months after contracting and recovering from the virus.

“Our evidence suggests that the journey to severe COVID-19 may be established immediately after infection, or at the latest around the time that they begin to show symptoms,” said Dr. Paul Lyons, a Cambridge academic and senior co-author of the study.

“This finding could have major implications as to how the disease needs to be managed, as it suggests we need to begin treatment to stop the immune system causing damage very early on, and perhaps even pre-emptively in high-risk groups screened and diagnosed before symptoms develop.”


In Bangladesh’s mangrove forest, villagers brave tigers to collect rare honey

Updated 58 min 55 sec ago
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In Bangladesh’s mangrove forest, villagers brave tigers to collect rare honey

  • Honey is gathered from wild bee colonies deep in the Sundarbans
  • Producers made a debut at the biggest food fair in Jeddah this month

DHAKA: When the harvest begins, Mizanur Rahman gathers a few hundred men and sets out into the mangrove forest along the Bay of Bengal, where for months they climb trees to collect by hand a wild natural honey whose unique properties are only starting to attract global attention.

The honey is collected from wild bee colonies deep within the Sundarbans, the world’s largest mangrove reserve spanning parts of India and southwestern Bangladesh.

“Honey collection from this forest is mostly done in the Bangladesh part,” Rahman said. “All plants, trees, and the overall environment of this forest are natural. There is no human touch.”

Sundarban honey comes from an ecosystem where trees grow and bloom naturally, without the use of fertilizers or pesticides. Its collectors, known as mawalis, begin work in March for about three and a half months.

Rahman estimates there are about 4,000 mawalis in the local community. To enter the forest, they require special passes from the forest department.

“It’s a very risky job for the people who enter the forest,” he told Arab News. “It’s the only honey in the world where collectors risk their lives in the den of the mighty Bengal tiger to gather it. Sometimes, they also face the danger of poisonous snake bites.”

During the season, his team reaches up to 1,200 members who together manage to collect about 400 tons of honey.

“One hundred small boats start sailing together, each carrying eight to 10 people,” Rahman said. “Despite the dangers, it is a matter of pride to be part of these challenging tasks.”

Collected from a humid environment, Sundarban honey is thinner than other types. Its greenish-amber shade comes from the nectar of mangrove flowers, and the taste is less sweet than most commercial honeys, with a subtle citrus-like tanginess. The scent is mild.

Being raw and unprocessed, the honey retains more enzymes, antioxidants, and pollen.

“Some people can feel acidity similar to orange juice,” Rahman said. “It has a unique taste. If someone tastes this honey once, she or he will definitely love to taste it again and again.”

Well known locally in Bangladesh and parts of eastern India, where it has been harvested and consumed for generations, Sundarban honey is only starting to gain attention in organic and specialty food markets.

Earlier this month, it debuted at AgroFood Jeddah, Saudi Arabia’s leading international exhibition for the agriculture, food, and agritech industries.

The organic honey from the Sundarbans received an encouraging reception, according to Mohammed Saleh Uddin Bhuyan, chief category officer at Ghorer Bazar, one of the companies participating in the expo.

“We have been receiving good responses from the local buyers,” he said. “Saudi Arabia is a very promising market for us.”

Bangladeshi authorities recognize the honey’s export potential but also the fact that production still needs to be standardized to enter global markets.

Mahmudul Hasan, director of Bangladesh’s Export Promotion Bureau, told Arab News that there are plans to promote the organic practices behind the honey during future food fairs in the Gulf region.

“There is huge export potential for our mangrove honey in the Gulf countries, as Arab consumers are fond of honey. They just need to be assured of the quality in the production process,” he said.

“Our mangrove honey is undoubtedly an organic product. It has unique value, but the world is not very aware of it yet.”