Pause to US trial of Oxford vaccine could threaten its success

Disruption to a US trial of the Oxford vaccine against the coronavirus disease (COVID-19) means it could miss a vital deadline to give its participants a secondary dose, it has been revealed. (Reuters/File Photo)
Short Url
Updated 07 October 2020
Follow

Pause to US trial of Oxford vaccine could threaten its success

  • The Oxford team in charge of the trial is at the forefront of the race to develop a working vaccine
  • Trial volunteers should receive a second dose 28 days after their first, with regulations only allowing for a three-day grace period

LONDON: Disruption to a US trial of the Oxford vaccine against the coronavirus disease (COVID-19) means it could miss a vital deadline to give its participants a secondary dose, it was revealed on Wednesday.

Due to a month-long halt of the trial imposed by US regulators investigating potential side-effects, volunteers have only been given one dose of the vaccine and are in danger of missing out on the necessary booster shot, the Times newspaper reported.

The Oxford team in charge of the trial is at the forefront of the race to develop a working vaccine, but could now face challenges in determining its effectiveness due to the pause in the US.

Enrollment in other trials in several countries around the world, being run by AstraZeneca in conjunction with researchers at Oxford University, was put on hold in September, after a participant in its UK trial suffered a rare spinal inflammatory disorder known as transverse myelitis.

While the British trial continued soon afterward — along with other testing in South Africa, Brazil, Japan and India — the American trial remains postponed.

“There is quite a lot of evidence that a longer interval (between shots) is actually better ... However, changing the interval midway through a trial can be problematic. Anyone who doesn’t get their vaccinations according to the stated schedule should be excluded from the final analysis of the trial,” Eleanor Riley, professor of immunology at the University of Edinburgh, told the Times.

“That means they may have to recruit additional people to make up the numbers. That will obviously add more delay to getting an answer.

“If a large group is affected by the delay, they may analyze their data anyway, as a secondary subgroup analysis, to see if the difference in timing has any effect,” she added.

Trial volunteers should receive a second dose 28 days after their first, with regulations only allowing for a three-day grace period.

AstraZeneca declined to confirm how many participants had been injected in the US before the trial was paused when asked by the Times.

However, AstraZeneca executive Mene Pangalos said the US trial was more of a confirmatory trial, according to a client note from Guggenheim.

The note also said that the US pause would not have much bearing on the vaccine’s approval chances since it would ultimately be determined by the results of the other trials.

And Prof. Robin Shattock of London’s Imperial College, who is developing a separate COVID-19 vaccine, told the Times that the gap in doses could improve protection from the disease.

“The one month hold (for the US trial) likely reflects that the FDA (Food and Drug Administration) have not felt that they have been given enough information to allow the trial to restart,” he said.


Bangladesh mourns Khaleda Zia, its first woman prime minister

Updated 30 December 2025
Follow

Bangladesh mourns Khaleda Zia, its first woman prime minister

  • Ousted ex-premier Sheikh Hasina, who imprisoned Zia in 2018, offers condolences on her death
  • Zia’s rivalry with Hasina, both multiple-term PMs, shaped Bangladeshi politics for a generation

DHAKA: Bangladesh declared three days of state mourning on Tuesday for Khaleda Zia, its first female prime minister and one of the key figures on the county’s political scene over the past four decades.

Zia entered public life as Bangladesh’s first lady when her husband, Ziaur Rahman, a 1971 Liberation War hero, became president in 1977.

Four years later, when her husband was assassinated, she took over the helm of his Bangladesh Nationalist Party and, following the 1982 military coup led by Hussain Muhammad Ershad, was at the forefront of the pro-democracy movement.

Arrested several times during protests against Ershad’s rule, she first rose to power following the victory of the BNP in the 1991 general election, becoming the second woman prime minister of a predominantly Muslim nation, after Pakistan’s Benazir Bhutto.

Zia also served as a prime minister of a short-lived government of 1996 and came to power again for a full five-year term in 2001.

She passed away at the age of 80 on Tuesday morning at a hospital in Dhaka after a long illness.

She was a “symbol of the democratic movement” and with her death “the nation has lost a great guardian,” Bangladesh’s interim leader Muhammad Yunus said in a condolence statement, as the government announced the mourning period.

“Khaleda Zia was the three-time prime minister of Bangladesh and the country’s first female prime minister. ... Her role against President Ershad, an army chief who assumed the presidency through a coup, also made her a significant figure in the country’s politics,” Prof. Amena Mohsin, a political scientist, told Arab News.

“She was a housewife when she came into politics. At that time, she just lost her husband, but it’s not that she began politics under the shadow of her husband, president Ziaur Rahman. She outgrew her husband and built her own position.”

For a generation, Bangladeshi politics was shaped by Zia’s rivalry with Sheikh Hasina, who has served as prime minister for four terms.

Both carried the legacy of the Liberation War — Zia through her husband, and Hasina through her father, Sheikh Mujibur Rahman, widely known as the “Father of the Nation,” who served as the country’s first president until his assassination in 1975.

During Hasina’s rule, Zia was convicted in corruption cases and imprisoned in 2018. From 2020, she was placed under house arrest and freed only last year, after a mass student-led uprising, known as the July Revolution, ousted Hasina, who fled to India.

In November, Hasina was sentenced to death in absentia for her deadly crackdown on student protesters and remains in self-exile.

Unlike Hasina, Zia never left Bangladesh.

“She never left the country and countrymen, and she said that Bangladesh was her only address. Ultimately, it proved true,” Mohsin said.

“Many people admire Khaleda Zia for her uncompromising stance in politics. It’s true that she was uncompromising.”

On the social media of Hasina’s Awami League party, the ousted leader also offered condolences to Zia’s family, saying that her death has caused an “irreparable loss to the current politics of Bangladesh” and the BNP leadership.

The party’s chairmanship was assumed by Zia’s eldest son, Tarique Rahman, who returned to Dhaka just last week after more than 17 years in exile.

He had been living in London since 2008, when he faced multiple convictions, including an alleged plot to assassinate Hasina. Bangladeshi courts acquitted him only recently, following Hasina’s removal from office, making his return legally possible.

He is currently a leading contender for prime minister in February’s general elections.

“We knew it for many years that Tarique Rahman would assume his current position at some point,” Mohsin said.

“He should uphold the spirit of the July Revolution of 2024, including the right to freedom of expression, a free and fair environment for democratic practices, and more.”