JEDDAH: Women will be able to find out how likely they are to develop breast cancer after a group of researchers in Manchester, Britain, carried out a gene test that could soon be used on high-risk groups, the BBC reported.
The Single Nucleotide Polymorphism test, which looks at 18 genetic variations known to affect the odds of developing breast cancer, is conducted on blood or saliva, and could reduce the number of women undergoing mastectomies.
The BRCA gene has been dubbed the “Angelina Jolie gene.” She revealed that she had a mastectomy after learning that she had an 87 percent chance of developing breast cancer.
Women with the BRCA mutation have a 30-90 percent risk of developing breast cancer, said Prof. Gareth Evans, who is leading the research into the test at the Manchester University Foundation Trust. The test will better inform women about whether to undergo a mastectomy, Evans added.
Women are given a percentage chance of developing breast cancer in the next 10 years and throughout their lifetime by combining the test’s results with data on breast density and the age a woman has children or reaches puberty.
Becky Measures, a radio presenter on Peak FM, had to remove a breast at the age of 24 soon after finding out that she carried the BRCA1 gene mutation. She also learned that she has to remove her womb and ovaries in the next four months.
“When they find that they have the BRCA1 or 2 gene, many women fear that they have to take action immediately,” said Measures. “The new test will give women more options and help them make a more informed decision.”
The test should be made widely available, said Evans, as it allows women to learn their likelihood of developing breast cancer. “This is a massive game-changer for breast cancer,” he said.
The team of researchers plan to look at samples from 60,000 women by working with Cambridge University and researchers in the US, Australia and Europe.
The team hopes to improve the gene test within two years to include up to 300 genetic variants that affect the likelihood of developing the disease.
The team is also researching whether the test can be used to understand how genes affect the risk of developing other forms of cancer, such as prostate, uterine, ovarian, lung and colorectal.
It could be useful to people with the BRCA gene mutation who have a high risk of developing ovarian cancer.
“The more we learn about the genetic components behind these increased risks of developing breast cancer in women who have a family history of the disease, the better the choice they can make about their health,” the BBC quoted Dr. Justine Alford, senior science communications officer at Cancer Research UK, as saying.
Helping women with no family history of breast cancer who may still have a genetic risk of developing the disease is next on the list, said Lester Barr, chairman of Prevent Breast Cancer, a Manchester-based charity that funded some of the research.
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New gene test to determine breast cancer risk
New gene test to determine breast cancer risk
’Starting anew’: Indonesians in disaster-struck Sumatra hold Christmas mass
SOUTH TAPANULI: At a church in Sumatra, dozens of worshippers sang hymns at a Christmas mass, gathered together for their first service since deadly floods swept the Indonesian island.
The Angkola Protestant Church, in the hard-hit South Tapanuli district, was festooned on Wednesday with balloons and simple Christmas decorations.
Outside, the street leading to the building was buried under mounds of debris and foliage.
Many in the congregation are still sheltering at evacuation sites after the disaster wreaked havoc on the island four weeks ago.
Churchgoer Krismanto Nainggolan said this year’s Christmas service was “different,” even as he noted joy in the bittersweet moment.
“The feelings are mixed. Every word of the pastor’s sermon made us want to cry,” he told AFP after the Christmas mass.
“But the spirit of Christmas... gave us strength,” he added.
Krismanto lost his house in the flooding, while many of his neighbors were killed.
According to the National Disaster Mitigation Agency, 1,129 people died, and more than 170 others are still missing.
While the annual monsoon season often brings heavy rain to Indonesia, this month’s deluge was among the worst disasters to strike Sumatra since a magnitude-9.1 earthquake triggered a massive tsunami in 2004.
In South Tapanuli, churchgoer Mea Rosmawati Zebua said she had not expected to be able to celebrate Christmas this year.
“In past years, Christmas was a routine. Now, (we are) very grateful because God still gives us the breath of life,” the 54-year-old told AFP.
While Christmas mass is typically held in the evening, the Angkola church moved its service to Wednesday afternoon ahead of rain forecast in the evening, pastor Yansen Roberto Ritonga said.
To prepare for the first service since the disaster, the church had to remove towering heaps of mud that had been washed inside.
Soldiers and police had helped clear the debris and driftwood.
On Wednesday afternoon, a man rang the church’s bell before the pastor’s entrance, marking the start of the mass.
Around 30 worshippers, each of them holding a lit candle, sung Christmas hymns.
Yansen said this year’s Christmas served as a moment of “reflection” for the congregation.
Churchgoer Krismanto said that despite the widespread damage and the personal cost of the disaster, he chose to see it as a new beginning.
“Our hopes depend solely on God because we are now starting over... our lives are starting anew,” he said.
The Angkola Protestant Church, in the hard-hit South Tapanuli district, was festooned on Wednesday with balloons and simple Christmas decorations.
Outside, the street leading to the building was buried under mounds of debris and foliage.
Many in the congregation are still sheltering at evacuation sites after the disaster wreaked havoc on the island four weeks ago.
Churchgoer Krismanto Nainggolan said this year’s Christmas service was “different,” even as he noted joy in the bittersweet moment.
“The feelings are mixed. Every word of the pastor’s sermon made us want to cry,” he told AFP after the Christmas mass.
“But the spirit of Christmas... gave us strength,” he added.
Krismanto lost his house in the flooding, while many of his neighbors were killed.
According to the National Disaster Mitigation Agency, 1,129 people died, and more than 170 others are still missing.
While the annual monsoon season often brings heavy rain to Indonesia, this month’s deluge was among the worst disasters to strike Sumatra since a magnitude-9.1 earthquake triggered a massive tsunami in 2004.
In South Tapanuli, churchgoer Mea Rosmawati Zebua said she had not expected to be able to celebrate Christmas this year.
“In past years, Christmas was a routine. Now, (we are) very grateful because God still gives us the breath of life,” the 54-year-old told AFP.
While Christmas mass is typically held in the evening, the Angkola church moved its service to Wednesday afternoon ahead of rain forecast in the evening, pastor Yansen Roberto Ritonga said.
To prepare for the first service since the disaster, the church had to remove towering heaps of mud that had been washed inside.
Soldiers and police had helped clear the debris and driftwood.
On Wednesday afternoon, a man rang the church’s bell before the pastor’s entrance, marking the start of the mass.
Around 30 worshippers, each of them holding a lit candle, sung Christmas hymns.
Yansen said this year’s Christmas served as a moment of “reflection” for the congregation.
Churchgoer Krismanto said that despite the widespread damage and the personal cost of the disaster, he chose to see it as a new beginning.
“Our hopes depend solely on God because we are now starting over... our lives are starting anew,” he said.
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