WASHINGTON: The most widely used COVID-19 vaccines may offer a surprise benefit for some cancer patients – revving up their immune systems to help fight tumors.
People with advanced lung or skin cancer who were taking certain immunotherapy drugs lived substantially longer if they also got a Pfizer or Moderna shot within 100 days of starting treatment, according to preliminary research being reported Wednesday in the journal Nature.
And it had nothing to do with virus infections.
Instead, the molecule that powers those specific vaccines, mRNA, appears to help the immune system respond better to the cutting-edge cancer treatment, concluded researchers from MD Anderson Cancer Center in Houston and the University of Florida.
The vaccine “acts like a siren to activate immune cells throughout the body,” said lead researcher Dr. Adam Grippin of MD Anderson. “We’re sensitizing immune-resistant tumors to immune therapy.”
Health Secretary Robert F. Kennedy Jr. has raised skepticism about mRNA vaccines, cutting $500 million in funding for some uses of the technology.
But this research team found its results so promising that it is preparing a more rigorous study to see if mRNA coronavirus vaccines should be paired with cancer drugs called checkpoint inhibitors — an interim step while it designs new mRNA vaccines for use in cancer.
A healthy immune system often kills cancer cells before they become a threat. But some tumors evolve to hide from immune attack. Checkpoint inhibitors remove that cloak. It’s a powerful treatment – when it works. Some people’s immune cells still don’t recognize the tumor.
Messenger RNA, or mRNA, is naturally found in every cell and it contains genetic instructions for our bodies to make proteins. While best known as the Nobel Prize-winning technology behind COVID-19 vaccines, scientists have long been trying to create personalized mRNA “treatment vaccines” that train immune cells to spot unique features of a patient’s tumor.
The new research offers “a very good clue” that maybe an off-the-shelf approach could work, said Dr. Jeff Coller, an mRNA specialist at Johns Hopkins University who wasn’t involved with the work. “What it shows is that mRNA medicines are continuing to surprise us in how beneficial they can be to human health.”
Grippin and his Florida colleagues had been developing personalized mRNA cancer vaccines when they realized that even one created without a specific target appeared to spur similar immune activity against cancer.
Grippin wondered if the already widely available mRNA coronavirus shots might also have some effect, too.
So the team analyzed records of nearly 1,000 advanced cancer patients undergoing checkpoint inhibitor treatment at MD Anderson – comparing those who happened to get a Pfizer or Moderna shot with those who didn’t.
Vaccinated lung cancer patients were nearly twice as likely to be alive three years after beginning cancer treatment as the unvaccinated patients. Among melanoma patients, median survival was significantly longer for vaccinated patients – but exactly how much isn’t clear, as some of that group were still alive when the data was analyzed.
Non-mRNA vaccines such as flu shots didn’t make a difference, he said.
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COVID-19 vaccines may help some cancer patients fight tumors
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COVID-19 vaccines may help some cancer patients fight tumors
- A healthy immune system often kills cancer cells before they become a threat
US moves to counter China in Bangladesh, plans to pitch defense alternatives
DHAKA: The United States is concerned about China’s expanding presence in South Asia and is planning to offer Bangladesh’s next government US and allied defense systems as alternatives to Chinese hardware, Washington’s ambassador to Dhaka told Reuters. Bangladesh votes in a general election on Thursday after a Gen Z-led uprising toppled India-allied premier Sheikh Hasina in August 2024. She has since taken refuge in New Delhi, allowing China to deepen its influence in Bangladesh as India’s presence wanes. China recently signed a defense agreement with Bangladesh to build a drone factory near the India border, worrying foreign diplomats. Bangladesh is also in talks with Pakistan to buy JF-17 Thunder fighter jets, a multi-role combat aircraft jointly developed with China.
“The United States is concerned about growing Chinese influence in South Asia and is committed to working closely with the Bangladeshi government to clearly communicate the risks of certain types of engagement with China,” US Ambassador Brent T. Christensen said in an interview on Tuesday.
“The US offers a range of options to help Bangladesh meet its military capability needs, including US systems and those from allied partners, to provide alternatives to Chinese systems,” he said without offering further details.
The Chinese foreign ministry did not immediately respond to a request for comment.
Christensen also said that President Donald Trump’s administration would “like to see a good relationship between Bangladesh and India to support stability in the region.” New Delhi-Dhaka relations have nosedived since Hasina fled, badly affecting visa services and cricket ties between the two neighbors.
COMMERCIAL DIPLOMACY IS PRIORITY
Christensen said many US businesses were looking at potentially investing in Bangladesh but would want the next government to show early and clear signs that it is “open for business.”
“Commercial diplomacy is one of our top priorities, and we look forward to working with the new government to build on progress made with the interim government, particularly in strengthening commercial, economic, and security ties,” he said.
Energy producer Chevron has been in Bangladesh for decades but not many other US companies are visible in the densely populated country of 175 million people, as high taxes and difficulties repatriating profits have created some hurdles.
There are no Starbucks or McDonald’s outlets in Bangladesh.
The envoy said Washington would work with “whichever government is elected by the Bangladeshi people.” The race is between two coalitions led by former allies, the Bangladesh Nationalist Party (BNP) and the Islamist Jamaat-e-Islami, with opinion polls suggesting the BNP holds an advantage.
AID FOR ROHINGYA REFUGEES
Regarding the 1.2 million Rohingya refugees sheltered in Bangladesh, the ambassador said the United States remained the largest contributor to humanitarian operations.
“The US remains the largest contributor to the Rohingya refugee response and continues robust health programming in Bangladesh,” he said, noting a recent $2 billion worldwide funding framework signed with the United Nations to improve the effectiveness of such assistance, including in Bangladesh.
He urged other international donors to take on a greater share of the burden.
“The US cannot sustain the bulk of the effort alone. International partners need to increase their support for the Rohingya response,” he said. In recent years, the UN refugee agency has been struggling to raise sufficient funds to support the Rohingya community, leading to cuts in their rations and the closure of some schools for them.
“The United States is concerned about growing Chinese influence in South Asia and is committed to working closely with the Bangladeshi government to clearly communicate the risks of certain types of engagement with China,” US Ambassador Brent T. Christensen said in an interview on Tuesday.
“The US offers a range of options to help Bangladesh meet its military capability needs, including US systems and those from allied partners, to provide alternatives to Chinese systems,” he said without offering further details.
The Chinese foreign ministry did not immediately respond to a request for comment.
Christensen also said that President Donald Trump’s administration would “like to see a good relationship between Bangladesh and India to support stability in the region.” New Delhi-Dhaka relations have nosedived since Hasina fled, badly affecting visa services and cricket ties between the two neighbors.
COMMERCIAL DIPLOMACY IS PRIORITY
Christensen said many US businesses were looking at potentially investing in Bangladesh but would want the next government to show early and clear signs that it is “open for business.”
“Commercial diplomacy is one of our top priorities, and we look forward to working with the new government to build on progress made with the interim government, particularly in strengthening commercial, economic, and security ties,” he said.
Energy producer Chevron has been in Bangladesh for decades but not many other US companies are visible in the densely populated country of 175 million people, as high taxes and difficulties repatriating profits have created some hurdles.
There are no Starbucks or McDonald’s outlets in Bangladesh.
The envoy said Washington would work with “whichever government is elected by the Bangladeshi people.” The race is between two coalitions led by former allies, the Bangladesh Nationalist Party (BNP) and the Islamist Jamaat-e-Islami, with opinion polls suggesting the BNP holds an advantage.
AID FOR ROHINGYA REFUGEES
Regarding the 1.2 million Rohingya refugees sheltered in Bangladesh, the ambassador said the United States remained the largest contributor to humanitarian operations.
“The US remains the largest contributor to the Rohingya refugee response and continues robust health programming in Bangladesh,” he said, noting a recent $2 billion worldwide funding framework signed with the United Nations to improve the effectiveness of such assistance, including in Bangladesh.
He urged other international donors to take on a greater share of the burden.
“The US cannot sustain the bulk of the effort alone. International partners need to increase their support for the Rohingya response,” he said. In recent years, the UN refugee agency has been struggling to raise sufficient funds to support the Rohingya community, leading to cuts in their rations and the closure of some schools for them.
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