Missiles were seen flying towards Israel in the early hours of Saturday, as the Israeli military said it identified missiles launched from Iran towards Israel.
Shortly after the fresh barrage the army said it had begun a new wave of strikes targeting Iranian infrastructure in Tehran. Israel also launched fresh attacks on Lebanon and said it was attacking Iranian and Hezbollah targets.
There was no immediate comment from Iran's Revolutionary Guard or Hezbollah. Hezbollah has fired rockets at Israel, sparking Israeli strikes on Beirut's southern suburbs and Lebanon's east and south.
Inside Israel, explosions could be heard as Israeli defenses activated to shoot down incoming Iranian fire.