Opinion

Ukrainian soldiers in Donetsk and Kharkiv have a clear vision of danger and glory alike

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Ukrainian artillery in action in Donetsk. (AN photo by Mykhaylo Palinchak) 
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Ihor Reznik, commander of the Kharkiv Territorial Brigade, told Arab News his soldiers “need drones for survey and proper armored vehicles.” (AN photo by Mykhaylo Palinchak)
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The Kharkiv Territorial Defense Battalion is dug in along the barren landscape, with deep trenches and sandbags piled high to protect its personnel from enemy fire. (AN photo by Mykhaylo Palinchak)
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Ukrainian soldiers in Donetsk prepare their Soviet-era artillery to launch attacks on Russian bases. (AN photo by Mykhaylo Palinchak)
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Ukrainian soldiers in Donetsk prepare their Soviet-era artillery to launch attacks on Russian bases. (AN photo by Mykhaylo Palinchak)
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Commander Oleksander trains local and foreign recruits train under his watchful eye at the AIDAR Battalion base in Kostyantynivka. (AN photo by Mykhaylo Palinchak)
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Oleksandr, commander of the Aidar Battalion, an assault unit of the Ukrainian Ground Forces, in Kostyantynivka, an industrial city in Donetsk. (AN photo by Mykhaylo Palinchak)
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Updated 01 April 2023

Ukrainian soldiers in Donetsk and Kharkiv have a clear vision of danger and glory alike

  • Local commander appreciates weapons donations, says troops lack technical skills and expertise to operate them
  • Loss of homes and livelihoods proved too much to bear for those who remained during Russian control

DONETSK: In Kostyantynivka, an industrial city in Donetsk, eastern Ukraine, just 20 kilometers southwest of the Bakhmut front line, local and foreign recruits train under the watchful eye of Oleksandr, commander of the Aidar Battalion, an assault unit of the Ukrainian Ground Forces.

Oleksandr, a handsome man in his 30s, has been a soldier since 2014, joining up shortly after his girlfriend’s father was taken captive by Russian-backed forces that same year. Since then, his prowess as a leader on the battlefield has seen him promoted to the rank of commander.

 

 

“I know how the enemy operates by now; their strategy is to create confusion and chaos. We run ours by critical thinking, by going over our mistakes and learning from them to do better in the next battle,” he told Arab News at the unit’s local barracks.

“We have been successful in most if not all of our battles, but we need more. We need more weapons, we need more drones, we need more support. We have been trying to produce our own weapons but it is not enough.”

Bakhmut has been the site of some of the bloodiest fighting since Russia launched what it called a “special military operation” on Feb. 24, 2022.




The Director (nom de guerre) inside underground bunker by the Russian border in Ukraine's Kharkiv region. (AN photo by Mykhaylo Palinchak)

The Office of the UN High Commissioner for Human Rights has verified a total of 8,317 civilian deaths during the invasion of Ukraine as of March 19. Furthermore, 13,892 people were reported to have been injured. However, the numbers could be higher.

According to recent estimates, the conflict has wounded or killed 180,000 Russian soldiers and 100,000 Ukrainian troops. Other Western sources estimate the war has caused 150,000 casualties on each side.

Russian armed forces and the Wagner Group — a private military contractor which has recruited from Russia’s jails — sent a massive land force to capture the region, stretching Ukrainian ammunition to the limit.

“We see the Russian soldiers trying to emulate our strategy,” said Oleksandr. “The Wagner soldiers consist of former convicts and drug addicts. They are running low on recruit numbers and have been relying on prisons to fill in their ranks.”

In their attempt to punch through Ukrainian lines, Russian forces have been using a technique known as the “fox den” strategy, in which a grenade is attached to a drone and dropped into Ukrainian trenches from above.




The Z letter, a tactical insignia of Russian troops in Ukraine, is seen on the captured Russian towed artillery to be refurbished at the brigade's workshop in Kharkiv region on February 20, 2023. (AFP)

Nevertheless, Russian losses on this stretch of the battlefield have been high, with an attrition rate more severe than that of the Ukrainian defenders. “We do not underestimate our enemy, but they keep making the same mistakes. I have a feeling they do not learn,” said Oleksandr.

“Russian walkie talkies have fallen into our possession. What we heard shows they’re stubborn. Their generals don’t care how — the command is to get the job done no matter what, no matter the cannon fodder.”

NATO’s member states have been supplying Ukraine with modern battle tanks and other high-tech weaponry, supplementing the old Soviet-era technology that has long been the mainstay of Ukraine’s war effort.

Oleksandr says he appreciates the weapons donations, but says his troops still lack the technical skills and expertise to operate, maintain and repair the new gear. “Regardless, we will never surrender,” he said.

The Aidar Battalion came to prominence in recent months thanks to its social media activity, clocking up some 4.5 million subscribers on its TikTok account.




AIDAR Assault Battalion soldier at an undisclosed base in Kostyantinivka, Donetsk, in Ukraine. (AN photo by Mykhaylo Palinchak)

Known as the “dancing soldiers,” short videos of its personnel performing traditional dances in full battle dress have become a source of inspiration and a morale boost for the wider Ukrainian armed forces and the public at large.

“You need to find a way to have fun, or else you won’t survive,” said Oleksandr. “I also make videos for my daughter, so she can see what her father is doing.”

Further to the northwest, in the Kharkiv region, the Kharkiv Territorial Defense Battalion is dug in along the barren landscape, with deep trenches and sandbags piled high to protect its personnel from enemy fire.

Most of the region was retaken from Russian forces in September 2022 during a massive Ukrainian counteroffensive, in what was viewed at the time as a significant turning point in the war. However, this momentum has since been lost, resulting in a bitter stalemate.




Ukrainian artillery unit soldier in Kostyantinivka, Donetsk. (AN photo by Mykhaylo Palinchak)

The months of fighting across this wide front left unfathomable carnage in its wake, with homes and businesses reduced to rubble and farmland churned up and left fallow.

“The Russians destroyed everything,” Yuriy, a local man in his 40s, told Arab News at his now-disused farm in Kharkiv. “We let our animals free from our barn to give them the chance to survive. Some I believe are still alive near the river.”

Many local families have chosen to leave the area for the comparative safety of western Ukraine and neighboring countries. For those who remained during the months of Russian control, the loss of homes and livelihoods proved too much to bear.




Yuriy, a farmer from Kharkiv, at his damaged home. (AN photo by Mykhaylo Palinchak)

“The building housed my parents, myself and my brother,” said Yuriy, pointing to his family’s damaged farmhouse.

“My father died of a heart attack. The conditions the Russians put us under didn’t aid his ailment. He couldn’t withstand it. He passed away. My mother and brother have relocated. I still return here from time to time.

“I don’t know where to start to rebuild. I think this will be the last time I am here.”

Despite their stalled progress, the Ukrainian armed forces stationed here remain in high spirits, but ever vigilant, their weapons trained on the horizon for signs of enemy activity.

“We are here to protect the border,” one soldier, who went by the nom de guerre “The Director,” told Arab News from his underground bunker.

“The shelling is the hardest to get used to, but we are here to protect our motherland. The shift keeps rotating and we are always on the lookout. There is no way back from here. We have enough food and warm clothes but we need more weapons. The Russians are not welcome here and we will not stop till we defeat them.”

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Several of the men serving in The Director’s battalion had little or no combat experience prior to their deployment, working as lawyers, teachers and civil servants, yet all have quickly adapted to their new realities. Few have seen their families in months.

“I took my children and wife to safety, but this is my town,” Ihor Reznik, commander of the Kharkiv Territorial Brigade, told Arab News. “We made it through hard battles. Now there is random shelling and we try to respond adequately. We need drones for survey and we need proper armored vehicles.”

Reznik’s daughter Anna, aged 25, serves in the Kharkiv Territorial Defense Battalion’s 127th Brigade. Before the war, she studied mathematics and computer science at a university in France.




Commander Ihor Reznik with his daughter Anna at the 127th Brigade base in Kharkiv region, Ukraine. (AN photo by Mykhaylo Palinchak)

Although she was close to graduation, she chose to quit her studies in order to join her father’s brigade, where she now serves as a military photographer for its press department.

“It’s always been a hobby, but now it is my way of serving in this war,” she told Arab News. “At the beginning, my parents were against it, but came to understand it was my decision. I need to document what is happening.”

And although she has frequently found herself in life-threatening situations while working in the field, she believes her commitment to the cause of documenting the conflict helps her to remain calm while under fire.

“When one has not been faced with such situations, one doesn’t know how to react. But I remain calm,” she said. “The camera is my weapon. No matter how difficult it gets, I never regret my decision. I know I am in the right place at the right time.”

 


More than 200 killed and 800 hurt after 2 trains derail in India

Updated 03 June 2023

More than 200 killed and 800 hurt after 2 trains derail in India

  • About 400 people were taken to hospitals after the accident, which happened in eastern India
  • Nearly 500 police officers and rescue workers with 75 ambulances and buses responded to the accident

NEW DELHI: Two passenger trains derailed Friday in India, killing more than 200 people and trapping hundreds of others inside more than a dozen damaged rail cars, officials said.
The accident that happened about 220 kilometers (137 miles) southwest of Kolkata created a chaotic scene of twisted wreckage and desperate rescuers as teams tried to free passengers and recover bodies. The cause was under investigation.
Fire Services Chief Sudhanshu Sarangi told the Press Trust of India that more than 800 people were hurt.
Ten to 12 coaches of one train derailed, and debris from some of the mangled coaches fell onto a nearby track, said Amitabh Sharma, a railroad ministry spokesperson.
The debris was hit by another passenger train coming from the opposite direction, and up to three coaches of the second train also derailed, Sharma said.
The Press Trust reported that a third train carrying freight was also involved, but there was no immediate confirmation from railroad authorities. The Press Trust report said some of the derailed passenger coaches hit cars from the freight train.
The death toll rose steadily throughout the night. As dawn approached, the top bureaucrat in the eastern state of Odisha announced that at least 207 were dead.
In the aftermath, television images showed rescuers climbing atop the wreckage to break open doors and windows and using cutting torches to free survivors.
Passenger Vandana Kaleda told the New Delhi Television news channel that she “found people falling on each other” as her coach shook violently and veered off the tracks. She said she was lucky to survive.
Another survivor who did not give his name said he was sleeping when the impact woke him up. He said he saw other passengers with broken limbs and disfigured faces.
Nearly 500 police officers and rescue workers with 75 ambulances and buses responded to the scene, said Pradeep Jena, the top bureaucrat of the Odisha state.
Rescuers were attempting to free 200 people feared trapped in the wreckage, Shinde said.
The Press Trust said the derailed Coromandel Express was traveling from Howrah in West Bengal state to Chennai, the capital of southern Tamil Nadu state.
Indian Prime Minister Narendra Modi said his thoughts were with the bereaved families.
"May the injured recover soon,” tweeted Modi, who said he had spoken to the railway minister and that “all possible assistance” was being offered.
Despite government efforts to improve rail safety, several hundred accidents occur every year on India’s railways, the largest train network under one management in the world.
In August 1995, two trains collided near New Delhi, killing 358 people in the worst train accident in India’s history.
Most train accidents are blamed on human error or outdated signaling equipment.
More than 12 million people ride 14,000 trains across India every day, traveling on 64,000 kilometers (40,000 miles) of track.

 

 


BRICS sees strength in numbers as it envisions a multipolar world order

Updated 03 June 2023

BRICS sees strength in numbers as it envisions a multipolar world order

  • Summit of foreign ministers in Cape Town sets the stage for a more ambitious role for BRICS in a multipolar world
  • Prince Faisal bin Farhan, Saudi minister of foreign affairs, attended ministerial meeting of the “Friends of BRICS” in Cape Town

LONDON: Foreign ministers from BRICS countries Brazil, Russia, India, China and South Africa have expressed their willingness to admit new members, including Saudi Arabia, as the bloc seeks a larger voice in the international arena. 

At a two-day conference in Cape Town on Thursday and Friday, attended by Prince Faisal bin Farhan, the Saudi minister of foreign affairs, the group presented itself as a force for a “rebalancing” of the global order away from Western-dominated institutions. 

Prince Faisal held bilateral talks with several of his counterparts and attended a ministerial meeting of the “Friends of BRICS” under the theme “Partnership for Mutually Accelerated Growth, Sustainable Development, and Inclusive Multilateralism.”

He also held talks with Hossein Amir-Abdollahian, Iran’s foreign minister, to examine steps “to implement the agreement between the two countries signed in Beijing, including intensifying bilateral work to ensure international peace and security,” according to a statement from the Saudi delegation. 

Saudi Foreign Minister Prince Faisal bin Farhan with Russian counterpart Sergey Lavrov. (MOFA/Twitter)

Saudi Arabia, the UAE, Iran, Cuba, DRC, Comoros, Gabon, and Kazakhstan all sent representatives to Cape Town for the talks, while Egypt, Argentina, Bangladesh, Guinea-Bissau and Indonesia participated virtually.

Russian Foreign Minister Sergei Lavrov said “more than a dozen” countries have expressed interest in joining BRICS. Meanwhile, Ma Zhaoxu, China’s vice foreign minister, told a press conference: “We expect more countries to join our big family.”

According to reports, Saudi Arabia, the UAE, Algeria, Egypt, Bahrain, and Iran have all formally asked to join the BRICS, as have several other nations who appear intent upon recalibrating international ties in line with an increasingly multipolar world order.

According to the Financial Times, Saudi Arabia is also in talks with the New Development Bank, the Shanghai-based lender better known as the “BRICS bank,” to admit the Kingdom as its ninth member.   

A heads of state summit is scheduled to take place in Johannesburg in August.

The BRICS economic bloc is positioning itself as an alternative to Western-dominated centers of power. However, experts seem uncertain about its potential, pointing to innate divisions between the central BRICS powers and a lack of clarity on what membership might entail.

Nevertheless, for several countries seeking financial assistance, the stringent demands often attached to bailouts by Western-dominated institutions like the IMF and World Bank have proved increasingly unpalatable, leading many nations to look elsewhere for partnerships.

A Tunisian man and his children return home on their cart in the central Tunisian city of Sidi Bouzid. (AFP)

One such example is Tunisia. 

Battered by diminishing output, high debt and rampant inflation, with food and fuel prices spiking, many saw the IMF’s offer of a $1.9 billion loan as Tunisia’s only way out of an escalating economic and political crisis.

President Kais Saied disagreed with this perspective, however, making his views on the deal very clear at the start of April, rejecting demands to cut energy and food subsidies and reduce the public wage bill, which the loan had been made contingent upon.

“I will not hear diktats,” Saied said, noting the deadly riots that ensued in 1983 after bread prices were raised, telling Tunisians they instead had to “count on themselves.”

Others close to Saied seem to think that he has different plans to stop the country’s economic rot.

Echoing Saied, Mahmoud bin Mabrouk, a spokesperson for the pro-presidential July 25 Movement, told Arab News that Tunisia would “not accept diktats or interference” and would now look to the BRICS as “a political, economic and financial alternative that will enable Tunisia to open up to the new world.”

Should bin Mabrouk’s claim hold weight, Tunisia would become the latest North African country to gravitate toward the bloc after Algeria applied to join late last year.

Such a move would suggest that the BRICS bloc is an expanding entity offering an alternative to the IMF and World Bank for states seeking bailouts.

However, Jim O’Neill, the economist who coined the BRICS acronym, questions “what” Tunisia would actually be signing up for, describing the bloc as more of a “political club” than any defined economic grouping, and one that seems to have had negative effects financially.

“As I’ve argued before, since the politic club came around, ironically, its economic strength has weakened,” O’Neill told Arab News. He further questions what criteria the bloc would seek in new members, suggesting that in the case of Algeria and Tunisia “it all just seems (like) symbolism.”

Symbolism or not, Algeria and Tunisia are not alone in their pivot toward the nascent bloc, with Argentina, Egypt, Indonesia, Iran, Saudi Arabia and Turkiye all considering tethering their futures to it.

Sarah Yerkes, a senior fellow at Carnegie’s Middle East Program, believes that Tunisia’s move should be taken seriously as it represents “an intentional geopolitical shift on its behalf,” noting the increased criticism of Tunisia from both Europe and the US.

“Tunisia is desperate for financial assistance and since the West is focused on conditioning aid to Tunisia on democratic reforms, it makes sense that Saied would seek assistance from countries that are less concerned with human rights and freedom,” Yerkes told Arab News.

However, like O’Neill, she questions whether the BRICS can offer an alternative to the IMF and World Bank, pointing to the bloc’s weak record when it comes to “assisting other countries and helping them achieve real, sustained economic prosperity.”

Internally, the BRICS group, at least, seems confident that it can rival the West. And, with the group set to meet in Johannesburg this August, South Africa’s foreign minister Naledi Pandor has reportedly suggested the launch of the economic bloc’s own currency, intended as a rival to dollar hegemony, would be firmly on the discussion table.

Even so, few commentators offer a defense of BRICS as a new economic bloc, with Elie Abouaoun, director of MENA at the US Institute of Peace, seeing Tunisia’s addition as a weight around the neck of a limited pool of “GDP contributors.”

The foreign ministers of South Africa and India. (Supplied)

“At this stage, the main contributors to global GDP among the BRICS countries are China and India, and most of the countries listed as potential candidates to become members are loan consumers rather than solid contributors to the global GDP,” Abouaoun told Arab News.

“With seven or eight new consumer countries integrating into the alliance, I see challenges for the largest BRICS member states and less, if any, financial benefit to the new ones. The alliance will certainly be weaker with more members so desperate to receive economic aid.”

Similarly, Liam Campling, professor of international business and development at Queen Mary University’s School of Business and Management, London, said that agreement by the BRICS cohort to admit Tunisia would be “slightly puzzling, given that it is a mid-level power.”

“When you look at the existing members, they are all sub-regional powers, each dominant in their part of the world, but when you look at Tunisia it is not dominant in North Africa in the same way Egypt is,” Campling told Arab News.

“So, from the BRICS perspective, it is not an obvious ally, but from the Tunisia side, it could obviously be an effort to garner wider macroeconomic support. Although what I think is happening is it is playing both sides, which is part of the play for any mid-ranking country.”

Campling’s skepticism stems from his assertion that while Tunisia may have fallen foul of the US, with increased political acrimony between the two, it is still very much economically “in bed” with the Europeans, adding “it’s not going to jeopardize its EU connections for this.”

And like the others, Campling has wider reservations about the BRICS project, pointing to what he terms the “central tension at the heart of it,” namely the long-running border disputes between China and India.

This, he suggests, renders the bloc more of an ad-hoc alliance than a cohesive unit that can direct global trade, policy and finance in a manner akin to that of the IMF or World Bank, and thus he questions the assertion that BRICS could become an alternative economic bloc.

“Essentially, I do not see it being able to offer a sustained alternative until that central tension between India and China is resolved, and I do not see that being resolved, which means there is nothing really holding it together, leaving little space for a more sustained role,” he said.

Abouaoun says what is really missing is a “normative model” that other countries can buy into beyond the BRICS bloc’s defense of “multipolarity.” Scratch beneath the surface and there seems to be an absence of substance — an opinion shared by Yerkes.

“At this point it doesn’t seem much more than a potential counterweight to Europe and the US, and without a foundational ideology, particularly with members with vastly different economic philosophies, it doesn’t seem likely that it would be a strong competitor,” she said.

Consensus on BRICS’ prospects notwithstanding, O’Neill is at odds with the others when it comes to the question of whether the world needs another economic bloc, believing focus should instead be on strengthening every economy, rather than acting in collectives.

Yerkes, Campling and Abouaoun seem less opposed to the notion of a new bloc, recognizing that US unipolarity seems to be on the way out. Nevertheless, they stress that the bloc’s value would be dependent on its make-up and its intentions.

Indeed, with the likes of Saudi Arabia potentially among its ranks, the BRICS could attain new levels of financial and diplomatic clout, transforming the international arena. 

“Historically, the dominance of the West, and its various international bodies and institutions, has been extremely self-serving, producing contradictory outcomes leading to a world that is more volatile and more uneven and increasingly depending on indebtedness,” Campling said.

“This has all been pushed in the interest of Europeans and the US. Maybe we should look to the 1970s and the Non-Aligned Movement — made up of many of those purportedly looking to join BRICS — for inspiration.”


UN, AU urge calm after deadly clashes in Senegal

Updated 02 June 2023

UN, AU urge calm after deadly clashes in Senegal

  • Nine people were killed on Thursday after popular opposition politician, Ousmane Sonko, was sentenced to two years in jail
  • The EU and Senegal's former colonial power France also expressed concern over the violence

DAKAR: The United Nations and African Union called for calm in Senegal Friday after an outbreak of deadly violence that prompted authorities to deploy the army.
Nine people were killed on Thursday after popular opposition politician, Ousmane Sonko, was sentenced to two years in jail, which may take him out of the running in 2024 presidential elections.
UN Secretary-General Antonio Guterres condemned the violence and “urged all those involved to (...) exercise restraint,” a spokesman said.
The African Union said its commission president, Moussa Faki Mahamat, strongly condemned the violence and urged leaders to avoid acts which “tarnish the face of Senegalese democracy, of which Africa has always been proud.”
The Community of West African States (ECOWAS) called on all parties to “defend the country’s laudable reputation as a bastion of peace and stability.”
The EU and Senegal’s former colonial power France also expressed concern over the violence.
Sonko was convicted for “corrupting” a young woman, in a case which has deeply divided Senegal, usually a bastion of stability in West Africa.
After some of the worst political violence in years on Thursday, tensions remained high on Friday, with sporadic clashes reported in the capital and soldiers deployed on the streets.
Sonko, who was tried in absentia, has yet to be taken into custody for his jail term, which is likely to cause further tensions.
The streets of the capital were largely deserted, AFP journalists observed.
The government acknowledged that it had restricted access to social networks such as Facebook, WhatsApp and Twitter in order to stop “the dissemination of hateful and subversive messages.”
There was extensive destruction on the main university campus, where prolonged clashes took place on Thursday.
Students with suitcases lined the streets outside the university, struggling to find transportation after being told to leave campus.
“We didn’t expect this, political affairs shouldn’t concern us,” said Babacar Ndiaye, a 26-year-old student.
“But there is injustice,” he added, referring to Sonko’s conviction.
Since 2021, when Sonko was initially arrested, around 30 civilians have been killed in unrest largely linked to his legal affairs.
The government and the opposition blame each other for the violence.
Sonko was initially charged with rape and issuing death threats against an employee of a beauty salon where he said he received massages.
However, the court acquitted him on these charges and convicted him for “debauching” a person under the age of 21, without clarifying the immoral acts he is alleged to have committed.
Under the electoral code, the verdict would appear to render him ineligible for next year’s election.
Sonko has maintained his innocence and claims the president is trying to frame him to keep him out of next year’s election — a charge the government denies.
The head of the PASTEF-Patriots party could be arrested “at any time,” Justice Minister Ismaila Madior Fall told journalists after the ruling on Thursday.
Dakar residents interviewed by AFP said they feared the possible consequences of an arrest.
“If they arrest him, we have to fear the worst,” says Yankouba Sane, a university employee.
“If there’s one person who will never go to prison in Senegal, it’s Ousmane Sonko,” said Alioune Diop, a 46-year-old shopkeeper. “If they put him on trial, they’re going to make the situation worse.”
Sonko is presumed to remain in his Dakar home, where he has been blocked in by security forces since the weekend. He alleges he is being “illegally held.”
International football star Sadio Mane, who is Senegalese, and the Khalifa General of Medina Baye, Serigne Mahi Ibrahim Niass — an eminent religious dignitary — have also called for peace.
Amnesty International urged authorities to stop “arbitrary arrests” and lift restrictions on access to social networks.
The NGO Reporters Without Borders also called on authorities to fully restore Internet access.
“Socio-political violence must not be used as a pretext to restrict the right to inform,” it said.


Novartis drug cuts recurrence risk by 25 percent in early-stage breast cancer

Updated 02 June 2023

Novartis drug cuts recurrence risk by 25 percent in early-stage breast cancer

  • The company on Friday said the relative risk reduction of cancer recurrence was 25.2%
  • The results were broadly consistent regardless of patients' menopausal status or cancer progression status

FRANKFURT: Novartis breast cancer drug Kisqali cut the risk of recurrence by more than 25 percent in a pivotal trial on women diagnosed at an early stage, positioning the Swiss drugmaker to win new patients and but facing strong competition from Eli Lilly.
The company on Friday said the relative risk reduction of cancer recurrence was 25.2 percent and that the results were broadly consistent regardless of patients’ menopausal status or cancer progression status. The results were presented at the annual meeting of the American Society of Clinical Oncology in Chicago.
The Swiss drugmaker’s shares rose, even as the efficacy read-out fell short of that of a drug by Lilly, but a more favorable side effect profile might swing the balance in favor of Kisqali.
The drug was used in the trial together with standard endocrine therapy to treat a type of cancer that grows in response to hormones and it was compared to endocrine therapy alone.
The Novartis treatment has been approved to treat hormone-driven breast cancer that has spread to other parts of the body, where Novartis has taken market share from Pfizer’s Ibrance.
But an earlier diagnosis, when tumors can still be surgically removed, is much more common, representing about 90 percent of patients.
Still, better drugs are needed after surgery because the cancer later returns in between a third and one half of cases.
Eli Lilly is ahead with the approval of rival drug Verzenio in the early setting. But that is in a subset of women who are at high risk of recurrence after surgery, typically diagnosed based on signs of cancer in the lymph nodes.
Here, Novartis will face tough competition because the US drugmaker has said Verzenio reduces the risk of recurrence by 35 percent in that group.
But Kisqali looks set to be a pioneer in a wider market because it was tested successfully in both high-risk and medium-risk patients, a population that is twice as large.
Analysts have said investors could be disappointed if the Kisqali read-out fell well short of Verzenio’s efficacy and Jefferies analysts said on Friday the efficacy read-out was “closer to our downside scenario.”
But Novartis stressed very low rates of symptomatic side effects in its trial, important to patients facing years-long treatment, with severe diarrhea affecting only 0.6 percent of participants on Kisqali.
That compares with 8 percent-20 percent of the women in trials with Eli Lilly’s Verzenio being affected by severe diarrhea.
“This may be very relevant commercially,” said Evercore ISI analyst Umer Raffat.
Novartis shares were up 1.5 percent at 1430 GMT, rebounding from initial losses after the news. Lilly shares gained 0.9 percent.
“We know diarrhea can be a very troublesome, burdensome adverse event for patients taking anti-cancer medicines,” said Jeff Legos, Head of Oncology & Hematology Development at Novartis.
The March trial update boosted market confidence in targets issued by CEO Vas Narasimhan for annual sales growth of 4 percent through 2027 and a core operating income margin of 40 percent from 2027, analysts have said.
Novartis will request approval for wider use in the US and Europe before the end of the year, it added.
Novartis gave a brief preview of the Kisqali data in March, boosting its shares and growth prospects.


Ukraine’s Zelensky: NATO membership ‘impossible’ until Russia war ends

Updated 02 June 2023

Ukraine’s Zelensky: NATO membership ‘impossible’ until Russia war ends

  • Western governments are wary of any move that might take the alliance closer to war with Russia

KYIV: President Volodymyr Zelensky said on Friday he knew it would be “impossible” for Ukraine to join NATO while Russia was waging war on his country.
Zelensky has pressed for Ukrainian membership of the military alliance but allies are divided over how fast that should happen. Western governments are wary of any move that might take the alliance closer to war with Russia.
In a joint briefing in the Ukrainian capital with Estonian President Alar Karis, he said joining the alliance was still the best security guarantee for Kyiv.
“But we are adequate people and understand that we will not pull any NATO country into a war,” Zelensky said. “And that’s why we understand that we won’t be a member of NATO while this war is ongoing. Not because we don’t want to, because it’s impossible.”