Pakistani startup using AI for breast cancer detection eyes FDA approval, Middle East expansion

The image shows people working at Pakistani startup Xylexa office in Islamabad, Pakistan, on November 29, 2022. (AN Photo)
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Updated 05 December 2022
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Pakistani startup using AI for breast cancer detection eyes FDA approval, Middle East expansion

  • Xylexa’s technology has gone through clinical trials at several medical facilities in Pakistan and abroad
  • Startup recently got its first contract in Lebanon and is now looking into opportunities in UAE, Saudi Arabia

ISLAMABAD: An award-winning Pakistani startup that uses artificial intelligence and cloud-based tools for breast cancer detection is now working on getting approval from the US Food and Drug Administration (FDA) and pursuing expansion into Arab countries, the founders of the firm said this week.

According to the International Agency for Research on Cancer (IARC), Pakistan has the highest breast cancer rate in Asia, with one out of nine Pakistani women now facing a lifetime risk of the disease. The country also has one of the highest breast cancer mortality rates globally.

Known as Xylexa, the Islamabad-based startup was founded in 2018 by entrepreneurs Shahid Abbasi, Shahrukh Babar, and Neda Nehal who met each other by chance at an IT industry event in 2017.

The three individuals thus embarked on a mission to fight the disease by empowering radiologists — medical doctors that specialize in diagnosing and treating injuries and diseases using medical imaging procedures — with tools and technologies that would render improved clinical outcomes for the patients.

“We have developed a decision support program for interpretation of medical images which use cutting edge technologies like artificial intelligence, computer vision, and deep learning that would help radiologists attain better clinical insights,” Abbasi, the co-founder of the startup, told Arab News in an interview in Islamabad this week.




Xylexa team poses for a picture after receiving the Pasha Technology of the Year Award in Islamabad, Pakistan on September 7, 2018. (Photo courtesy: Xylexa)

The inspiration to do something for breast cancer patients came when a close relative was diagnosed with the disease at a very late stage, he said.

“We got together as a group and decided to do something about it and use technology as a medium to save more lives,” Abbasi added.

The first set of algorithms that Xylexa developed was for the detection of breast cancer using mammography, he said, and its clinical evaluation was successfully concluded after the hard work of three and half years.

“We are not just stopping at mammography but now we are focused on developing support for 14 different diseases that require chest x-rays and have also developed algorithms for protection of blockages within the arterial system,” Abbasi said.




 Lieutenant General Nigar Johar, Surgeon General Pakistan Army (2nd right) is visiting Xylexa office in Islamabad, Pakistan on September 13, 2021. (Photo courtesy: Xylexa)

The entrepreneur said his company’s product delivered results with an up to a 95 percent accuracy ratio, thus giving 24 percent better results than traditional radiology examination.

“If you look at the market data available for the accuracy of radiologists’ readings, it ranges anywhere between 71 percent to 82 percent. On the other hand, the accuracy rates of three algorithms that we have developed for mammography, chest x-ray, and peripheral artery disease detection ranges anywhere between 89 percent to 95 percent,” he added.

After developing an AI and cloud-based platform to provide support for breast cancer detection, Xylexa put it through clinical validation at various medical facilities in Pakistan and abroad.

According to StartUs Insights, an Austrian company that has evaluated almost 359 companies across the globe using artificial intelligence in health care, Xylexa was among the top five performers in this domain.

Babar, another co-founder of the startup, said the team was now applying for approval from the Food and Drug Administration (FDA) in the United States after completing clinical trials.

“We ran a trial in Pakistan with Fouji Foundation Hospital, Islamabad Diagnostic Center, and Epiphany Labs,” he said, adding that the startup was also expanding to Arab countries.

“Recently, we got our first contract in Lebanon and we are looking at a few opportunities in Saudi Arabia too. We have already carried out trials with the King Fahad Hospital in the Kingdom and now are in talks with a few potential partners in Dubai as well.”

Babar said breast cancer could be successfully cured with early detection.

“If breast cancer is diagnosed at an early stage, chances of survival are 90 percent,” he said. “If it is diagnosed at a later stage, then chances of survival remain 25 percent or even less.”


Pakistan to open today televised bidding for privatization of loss-making flag carrier PIA

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Pakistan to open today televised bidding for privatization of loss-making flag carrier PIA

  • Pakistan plans to privatize 75 percent of the carrier, while retaining its name and branding
  • Three contenders remain in race to buy the airline after Fauji Fertilizer Company’s withdrawal

ISLAMABAD: Pakistan is set to hold a live broadcast bidding process today, Tuesday, for the privatization of the Pakistan International Airlines (PIA), officials said, with three consortiums contending to buy the loss-making national flag carrier.

The government prequalified four investor groups in July, but Fauji Fertilizer Company, part of a military-backed conglomerate, withdrew from the process recently.

The remaining contenders include two consortiums led by Lucky Cement and Arif Habib Corporation, and a private airline Airblue.

Pakistan aims to privatize 75 percent of the carrier, while retaining its name and branding, according to PM Shehbaz Sharif’s office. The decision marks Islamabad’s most aggressive push in decades to reform the debt-ridden airline, which has accumulated more than $2.8 billion in losses.

Speaking to Arab News, Muhammad Ali, adviser to the prime minister on privatization, said the exit of Fauji Fertilizer Company from the bidding process does not preclude future collaboration.

“We don’t know if Fauji [Fertilizer Company] will partner or not with the winning bidder. However, they have withdrawn from the race,” he said.

The sealed bids will be submitted by the bidders at 10:30am on Tuesday.

“Reference price for PIACL’s (Pakistan International Airlines Corporation Limited) bidding will only be approved by the Privatization Commission Board and the Cabinet Committee on Privatization after bids have been received,” the government said in a statement on Monday.

“The bids will be opened in a ceremony starting at 3:30pm [on Tuesday] in the presence of the bidders. The bids and the reference prices will be announced and the bidding will be concluded as per agreed terms.”

PIA’s sale is a central to Islamabad’s economic reform agenda under a $7 billion bailout agreed last year with the International Monetary Fund (IMF). Officials say the airline’s privatization is essential to halt recurring losses, revive international routes and ease pressure on the budget.

This is Pakistan’s third attempt at PIA privatization, following a failed 2024 auction that received only one bid of $35 million that was far below the government’s nearly $300 million asking price, according to Privatization Commission records. Islamabad is targeting $302 million in privatization proceeds this year.

“Privatization of PIA will avoid burden on exchequer, expand airline’s fleet, improve service quality, create employment opportunities, and help Pakistan’s aviation, tourism and GDP (gross domestic product) to grow,” Ali said.

Once considered among Asia’s leading airlines, PIA has accumulated more than $2.8 billion in losses. The airline has struggled with chronic mismanagement, political interference, overstaffing, mounting debt and operational issues that led to a 2020 ban on flights to the European Union, United Kingdom and the United States (US) after a pilot licensing scandal, further shrinking PIA revenues.

Pakistan’s Finance Adviser Khurram Schehzad said PIA used to be the region’s “best airline” in the 70s and 80s, adding that Pakistani diaspora in various countries wants their own airline to flourish again.

“Airlines help turnaround the economy, promote growth, investment and economic activity through multiple ways,” he said, noting, “We are a country of 250 million people, with a huge diaspora.”

Former finance minister Miftah Ismail believed the airline’s privatization would benefit consumers and taxpayers even if it did not materially move the macroeconomic needle.

“PIA’s privatization will have a positive impact on the aviation industry,” he told Arab News. “There will be greater competition and hopefully better service for consumers. It will also save the money people of Pakistan have to pay every year for PIA to keep going.”

Ismail noted the government had already transferred around Rs800 billion ($2.85 billion) of PIA’s liabilities onto the public balance sheet ahead of the sale.

“So, PIA has lost 800 billion rupees of people’s money. That money is gone forever and the consumers will have to pay, but at least further losses will be cut,” he said.

To a question, he said the process of privatization was “transparent” this time around but cautioned that broader privatization momentum remains limited only to state assets like power companies, oil exploration groups and gas distribution companies.

Islamabad has launched a five-year privatization plan covering 24 state entities between 2024 and 2029, including the Roosevelt Hotel in New York, three banks, power distribution companies, and the Postal Life Insurance Company, according to the Privatization Commission.

Aviation industry veterans say structural constraints under state ownership doomed repeated turnaround plans for PIA.

Speaking to Arab News, former PIA chief executive officer Musharraf Rasool Cyan pointed to “pervasive interference” and “rigid” public-sector rules for the failure of PIA.

“Due to interference by institutions like the judiciary and even parliament, the management cannot take market-aligned decisions,” he said, citing non-performance-based contracts, slow procurement rules, union pressures and corruption.

Cyan said PIA failed to adapt as competition intensified from the 1990s, lagged in network optimization and technology, and suffered from weak accountability.

“The work culture became more political than professional,” he said, adding the airline now needs equity injections and a fleet renewal.