AstraZeneca said on Thursday that preliminary data from a trial showed that its COVID-19 shot, Vaxzevria, generated an increase in antibodies against the omicron and other variants when given as a third booster dose.
The increased response, also against the Delta variant, was seen in a blood analysis of people who were previously vaccinated with either Vaxzevria or an mRNA vaccine, the drugmaker said, adding that it would submit this data to regulators worldwide given the urgent need for boosters.
AstraZeneca has developed the vaccine with researchers from the University of Oxford, and lab studies conducted by the university last month already found a three-dose course of Vaxzevria boosted antibody levels in the blood against the rapidly spreading omicron variant.
The brief statement on Thursday, which did not include specific data, was the first by AstraZeneca on the protective potential of Vaxzevria as a booster shot following a two shot-course of either an mRNA based vaccine or Vaxzevria. Vaccines based on mRNA technology are made by BioNTech-Pfizer and Moderna.
The company said the findings “add to the growing body of evidence supporting Vaxzevria as a third dose booster irrespective of the primary vaccination schedules tested.”
The data on Vaxzevria’s potential as a booster came from a comparative analysis in a trial testing a redesigned vaccine which uses the vector technology behind Vaxzevria but targeting the now-superseded Beta variant. AstraZeneca is trying to show the Beta-specific vaccine has potential also against other variants and more trial data is expected during the first half of the year.
Separately, Oxford University and AstraZeneca last month started work on a vaccine specifically targeting omicron though Astra — as well as other vaccine makers in similar development projects — have said it was not yet clear whether such an upgrade was needed.
A major British trial in December found that AstraZeneca’s shot increased antibodies when given as a booster after initial vaccination with its own shot or Pfizer’s, but that was before the explosive spread of the omicron variant.
However, the study at the time concluded that mRNA vaccines made by Pfizer and Moderna gave a biggest boost to antibodies when given as a third dose.
AstraZeneca and its contract manufacturing partners have supplied over 2.5 billion doses globally of its vaccine, even though it is not approved in the United States, while BioNTech-Pfizer have shipped about 2.6 billion doses.
AstraZeneca says early trial data indicates third dose helps against omicron
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AstraZeneca says early trial data indicates third dose helps against omicron
- The brief statement was the first by AstraZeneca on the protective potential of Vaxzevria as a booster shot following a two shot-course of either an mRNA based vaccine or Vaxzevria
Top Australian writers’ festival canceled after Palestinian author barred
SYDNEY: One of Australia’s top writers’ festivals was canceled on Tuesday, after 180 authors boycotted the event and its director resigned saying she could not be party to silencing a Palestinian author and warned moves to ban protests and slogans after the Bondi Beach mass shooting threatened free speech.
Louise Adler, the Jewish daughter of Holocaust survivors, said on Tuesday she was quitting her role at the Adelaide Writers’ Week in February, following a decision by the festival’s board to disinvite a Palestinian-Australian author.
The novelist and academic Randa Abdel-Fattah said the move to bar her was “a blatant and shameless act of anti-Palestinian racism and censorship.”
Prime Minister Anthony Albanese on Tuesday announced a national day of mourning would be held on January 22 to remember the 15 people killed in last month’s shooting at a Jewish Hanukkah celebration on Bondi Beach.
Police say the alleged gunmen were inspired by the Islamic State militant group, and the incident sparked nationwide calls to tackle antisemitism, and prompted state and federal government moves to tighten hate speech laws.
The Adelaide Festival board said on Tuesday its decision last week to disinvite Abdel-Fattah, on the grounds it would not be culturally sensitive for her to appear at the literary event “so soon after Bondi,” was made “out of respect for a community experiencing the pain from a devastating event.”
“Instead, this decision has created more division and for that we express our sincere apologies,” the board said in a statement.
The event would not go ahead and remaining board members will step down, it added.
Former New Zealand Prime Minister Jacinda Ardern, British author Zadie Smith, Australian author Kathy Lette, Pulitzer Prize-winning American Percival Everett and former Greek finance minister Yanis Varoufakis are among the authors who said they would no longer appear at the festival in South Australia state, Australian media reported.
The festival board on Tuesday apologized to Abdel-Fattah for “how the decision was represented.”
“This is not about identity or dissent but rather a continuing rapid shift in the national discourse around the breadth of freedom of expression in our nation following Australia’s worst terror attack in history,” it added.
Abdel-Fattah wrote on social media that she did not accept the apology, saying she had nothing to do with the Bondi attack, “nor did any Palestinian.”
Adler earlier wrote in The Guardian that the board’s decision to disinvite Abdel-Fattah “weakens freedom of speech and is the harbinger of a less free nation, where lobbying and political pressure determine who gets to speak and who doesn’t.”
The South Australian state government has appointed a new festival board.
