UK to launch vaccine trials on COVID-19 variants in summer

trials are underway to judge whether mixing vaccines will provide better protection against COVID-19. (AFP)
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Updated 24 February 2021
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UK to launch vaccine trials on COVID-19 variants in summer

  • The new versions of the vaccine are being produced in case COVID-19 variants substantially evade immunity provided by the current jabs

LONDON: British clinical trials of vaccines against new variants of COVID-19 will start in the summer to prepare updated jabs for the autumn if variants evade the current inoculations, the Oxford University vaccine group’s lead researcher has told the UK Parliament.

Prof. Sarah Gilbert said her team is producing an initial group of vaccines against new variants that are at least partially resistant to the current jabs being rolled out.

The new versions of the vaccine are being produced in case COVID-19 variants substantially evade immunity provided by the current jabs.

A small trial in South Africa found that a variant that emerged there, and which has since arrived in the UK, is partially resistant to the Oxford vaccine.

Vaccines from Novavax and Johnson & Johnson also appear less effective against the South African variant.

“We need to make preparations so that everything is in place, if it turns out that we do need to do it,” Gilbert told British MPs.

“Currently, the plans are to be ready for an immunization campaign in the autumn, so before going into the winter season we’d have a new variant vaccine available if it turns out that’s what’s going to be required,” she added.
“If we see the emergence of a new strain very close to that date, it’s going to be difficult to go through this whole process, because we do need to conduct a clinical study and get regulatory approval, in time to be vaccinated before the winter.”
Gilbert said trials are underway to judge whether mixing vaccines will provide better protection against COVID-19 by stimulating the immune system in different ways.
The Oxford vaccine group is also looking at producing nasal spray and pill alternatives to the standard inoculation.
 


Pakistani fighter jet crashes in Jalalabad, pilot captured: Afghan military, police

Updated 42 min 34 sec ago
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Pakistani fighter jet crashes in Jalalabad, pilot captured: Afghan military, police

  • Fighting between Pakistan and Afghanistan’s Taliban military entered its third day on Saturday
  • Pakistan’s strikes on Friday hit Taliban military installations and posts, including in Kabul and Kandahar

JALALABAD: A Pakistani jet has crashed in Jalalabad city and the pilot captured alive, the Afghan military and police said Saturday, with residents telling AFP the man parachuted from the plane before being detained.
"A Pakistani fighter jet was shot down in the sixth district of Jalalabad city, and its pilot was captured alive," police spokesman Tayeb Hammad said.
Wahidullah Mohammadi, spokesman for the military in eastern Afghanistan, confirmed the Pakistani jet was downed by Afghan forces "and the pilot was captured alive".

The AFP journalist heard a jet overhead before blasts from the direction of the airport in Jalalabad, the capital of Nangarhar province, which sits on the road between Kabul and the Pakistani border.

Fighting between Pakistan and Afghanistan’s Taliban military entered its third day on Saturday, following overnight clashes as the international community expressed increasing concern about the conflict and called for urgent talks.

Pakistan’s strikes on Friday hit Taliban military installations and posts, including in Kabul and Kandahar, in one of the deepest Pakistani incursions into its western neighbor in years, officials said.

Islamabad accuses the Taliban of harboring Tehreek-e-Taliban Pakistan (TTP) militants, who it claims are waging an insurgency inside Pakistan, a charge the Taliban denies.

Pakistan described its actions as a response to cross-border assaults, while Kabul denounced them as a breach of its sovereignty, saying it remained open to dialogue but warned any wider conflict would result in serious consequences.

The fighting has raised ‌the risk ‌of a protracted conflict along the rugged 2,600-kilometer frontier.

Diplomatic efforts gathered ‌pace ⁠late on Friday ⁠as Afghanistan said its foreign minister, Amir Khan Muttaqi, spoke by telephone with Saudi Arabia’s Prince Faisal bin Farhan about reducing tensions and keeping diplomatic channels open.

The European Union called for both sides to de-escalate and engage in dialogue, while the United Nations urged an immediate end to hostilities.

Russia urged both sides to halt the clashes and return to talks, while China said it was deeply concerned and ready to help ease tensions.

The United States supports Pakistan’s right to defend itself against attacks by ⁠the Taliban, a State Department spokesperson said.

Border fighting continues

Exchanges of fire continued along ‌the border overnight.

Pakistani security sources said an operation dubbed “Ghazab Lil Haq” was ongoing and that Pakistani forces had destroyed multiple Taliban posts and camps in several sectors. Reuters could not independently verify the claims.

Both sides have reported heavy losses with conflicting tolls that Reuters could not verify. Pakistan said 12 of its ‌soldiers and 274 Taliban were killed while the Taliban said 13 of its fighters and 55 Pakistani soldiers died.

Taliban deputy spokesman Hamdullah Fitrat ⁠said 19 civilians were ⁠killed and 26 wounded in Khost and Paktika. Reuters could not verify the claim.

Pakistan’s Defense Minister Khawaja Muhammad Asif said “our cup of patience has overflowed” and described the fighting as “open war,” warning that Pakistan would respond to further attacks.

Taliban Interior Minister Sirajuddin Haqqani said in a speech in Khost province that the conflict “will be very costly,” and that Afghan forces had not deployed broadly beyond those already engaged.

He said the Taliban had defeated “the world, not through technology, but through unity and solidarity,” and through “great patience and perseverance,” rather than superior military power.

Pakistan’s military capabilities far exceed those of Afghanistan, with a standing army of hundreds of thousands and a modern air force.

In stark contrast, the Taliban lacks a conventional air force and relies largely on light weaponry and ground forces.

However, the Islamist group is battle-hardened after two decades of insurgency against US-led forces before returning to power in 2021.