Long COVID could depend on severity of early infection: Study

The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study. (Reuters/File Photo)
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Updated 18 January 2021
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Long COVID could depend on severity of early infection: Study

  • ‘This finding could have major implications as to how the disease needs to be managed’

LONDON: The speed at which a person’s immune system responds to infection with COVID-19 plays a key role in determining the disease’s long-term severity, according to a new UK study.

Researchers from Cambridge University studied 207 people who tested positive for COVID-19 over three months, finding that subjects with mild or no symptoms offered a rapid, strong immune response soon after infection.

The 207 people in the experiment ranged from asymptomatic healthcare workers to patients requiring ventilation. 

The team analyzed blood samples taken regularly over three months, and compared them with others taken from 45 healthy people.

The healthiest in the study produced anti-virus cells in larger numbers than the patients with severe COVID-19 infections. The first group also developed immunity cells within the first week of infection.

But the people with severe cases who required hospitalization were found to have an impaired immune response, which frustrated the body’s attempts to fight the virus, leading to more severe infection.

This weakened response to COVID-19 is characterized by inflammation of several organs, which starts right after a person catches the disease. 

Scientists say abnormalities in immune cells could explain the slower response to viral infection as well as the organ inflammation.

These two crucial factors could contribute to the severity of the disease and the phenomenon known as long COVID, where people feel symptoms and have health issues many months after contracting and recovering from the virus.

“Our evidence suggests that the journey to severe COVID-19 may be established immediately after infection, or at the latest around the time that they begin to show symptoms,” said Dr. Paul Lyons, a Cambridge academic and senior co-author of the study.

“This finding could have major implications as to how the disease needs to be managed, as it suggests we need to begin treatment to stop the immune system causing damage very early on, and perhaps even pre-emptively in high-risk groups screened and diagnosed before symptoms develop.”


Built on ancient design, Indian Navy’s first stitched ship sails to Oman

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Built on ancient design, Indian Navy’s first stitched ship sails to Oman

  • INSV Kaundinya is a 21-meter wooden ship modeled on painting from Ajanta Caves
  • It was constructed by artisans from Kerala and inducted into Indian Navy last year

NEW DELHI: Built using a fifth-century stitched-ship technique, the Indian Navy’s Kaundinya vessel is approaching Oman, navigating the historic Arabian Sea route once traveled by ancient seafarers.

The 21-meter ship is a type of wooden boat, in which planks are stitched together using cords or ropes, a technique popular in ancient India for constructing ocean-going vessels.

The vessel set sail on its first transoceanic voyage from Porbandar in Gujarat on Dec. 29 and is expected to reach Muscat in mid-January.

“The exact date obviously depends on how weather conditions pan out. It has been a great experience thus far and the crew remains in high spirits,” Sanjeev Sanyal, an Indian economist who initiated the Kaundinya project and is part of the expedition, told Arab News.

“This is a very ancient route going back to the Bronze Age, and very active from ancient to modern times. We are trying to re-create the voyage on INSV Kaundinya, a ‘stitched’ ship using designs as they would have existed in the fifth century A.D. — a hull from stitched planks, steering oars, square sails, and so on.”

The ship was built by artisans from Kerala based on a painting found in the Ajanta Caves, a UNESCO World Heritage Site in Maharashtra state, where rock-cut monuments feature exquisite murals dating from the second century B.C. to the fifth century.

INSV Kaundinya crew members pose for photo on the third day of their voyage from Gujarat to Oman, Dec. 31, 2025. (INSV Kaundinya)

Funded by the Indian Ministry of Culture in 2023, the vessel was completed in February last year and inducted into the Indian Navy in May.

The Indian Navy collaborated with the Department of Ocean Engineering at the Indian Institute of Technology-Madras to conduct model testing of the vessel’s hydrodynamic performance. The navy also tested the wooden mast system, which was built entirely without modern materials.

On its journey to Muscat, the ship is manned by an 18-member crew, which, besides Sanyal, consists of four officers, 12 sailors, and a medic.

“The voyage gives a good glimpse of how ancient mariners crossed the Indian Ocean — the changing winds and currents, the limitations of ancient technology,” Sanyal said.

“The square sail, for example, allows the ship to sail only up to a limited angle to the wind compared to a modern sailing boat. It also does not have a deep keel, so it rolls a lot. “Nonetheless, in good winds, it can do up to five knots — a very respectable speed. One reads about these voyages in ancient texts and (they are also) depicted in paintings and sculpture, but this provides a real experience.”