Indonesia begins human trials of anti-virus vaccine

Indonesia, the world’s fourth most populous country, has been struggling to contain its mounting virus cases. (AFP)
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Updated 12 August 2020

Indonesia begins human trials of anti-virus vaccine

  • The third phase of the clinical trials of the vaccine — which is manufactured by China’s Sinovac Biotech in collaboration with its Indonesian pharma counterpart, Bio Farma — began on Tuesday
  • The third phase is a must before the vaccine, known as CoronaVac, goes into the production stage and is a prerequisite for all pharmaceutical products, including medicines and vaccines

JAKARTA: Indonesia is stepping up efforts to find a COVID-19 vaccine by launching human trials of a potentially effective drug amid criticism of its lacklustre handling of the pandemic and concerns about its plummeting economy.

The third phase of the clinical trials of the vaccine — which is manufactured by China’s Sinovac Biotech in collaboration with its Indonesian pharma counterpart, Bio Farma — began on Tuesday and is being conducted by the Padjadjaran University School of Medicine at six locations in Bandung, West Java province, where the university and the state-owned pharma company are based.

“The first day of the trial went well, with 20 volunteers in each of the six locations injected with the potential vaccine. We have no complaints so far, and we are preparing the second injection batch on Aug 14,” Iwan Setiawan, a spokesman for Bio Farma, told Arab News on Wednesday.

He added that the six-month trial would require the participation of 1,620 volunteers who were “in good health and had not tested positive” for the disease.

Ridwan Kamil, governor of West Java, Indonesia’s most populated province, is among the volunteers who have signed up for the trial.

The third phase is a must before the vaccine, known as CoronaVac, goes into the production stage and is a prerequisite for all pharmaceutical products, including medicines and vaccines.

“The potential vaccine had gone through three trials; the pre-clinical, the clinical trial first phase and the second phase in China,” Bio Farma CEO Honesti Basyir said in a statement.

According to Basyir, Sinovac is one of the few institutions that have progressed to the third phase of the clinical trial from among hundreds of research institutions around the world that are developing the COVID-19 vaccine.

According to Oxford Business Group’s COVID-10 Economic Impact Assessment, there are more than 150 different vaccines that international researchers are working on. However, only 26 have reached the human trial stage so far.

Once the trials are concluded, Bio Farma will register the vaccine with the Food and Drug Supervisory Agency so that it can begin mass-production of the drug.

“We have prepared a production facility for the COVID-19 vaccine with a maximum capacity of 100 million dosages, and by the end of December this year we will have an increased production capacity to produce an additional 150 million dosages,” Basyir said.

President Joko Widodo oversaw the first injections to the batch of volunteers in one of the six locations and also toured Bio Farma’s production facility. 

“We hope this clinical trial would conclude in six months and so we can start producing the vaccine in January and vaccinate our people soon,” Widodo said.

State-Owned Enterprise Minister Erick Thohir, who is also the head of the COVID-19 mitigation and national economic recovery committee, said that Bio Farma was a well-established vaccine producer whose products were halal-compliant and used in 150 countries, including in the Middle East.

The collaboration with Sinovac is one of three vaccine-development projects that Indonesia is engaging in with foreign parties as it grapples with a surge in infections. At the same time, social restrictions and economic activities were eased. The other two projects are with South Korea’s Genexine and Norway’s Coalition for Epidemic, Preparedness and Innovation.

As of Wednesday, Indonesia had reported 130,718 infections with 1,942 new cases, 85,798 recoveries and 5,903 deaths, although experts suggest that the numbers could be higher due to the country’s low testing capacity.

Cases also surged in the capital Jakarta with workplaces emerging as the new infection clusters after thousands of employees returned to work recently.


At least two killed as car ploughs into pedestrian zone in German town

Updated 01 December 2020

At least two killed as car ploughs into pedestrian zone in German town

  • The driver was arrested and the vehicle was impounded, Trier police tweeted
  • Two people have died, and 15 others had suffered serious injuries

BERLIN: At least two people including a child were killed and up to 15 injured on Tuesday when a speeding car ploughed into a pedestrian area in the western German city of Trier, authorities said.
Witnesses said people screamed in panic and some were thrown into the air by the car as it crashed through the shopping zone.
Police said several people had been killed, having earlier put the death toll at two, with more than 10 injured. The local newspaper, the Trierischer Volksfreund, put the death toll at four, including a child, but police did not confirm that figure.
"We have arrested one person, one vehicle has been secured," police said, adding that a 51-year-old German suspect from the Trier area was being questioned, police said.
Mayor Wolfram Leibe had rushed to the scene.
"We have a driver who ran amok in the city. We have two dead that we are certain of and up to 15 injured, some of them with the most severe injuries," he told public broadcaster SWR.
"I just walked through the city centre and it was just horrible. There is a trainer lying on the ground, and the girl it belongs to is dead," he told a news conference, with tears stopping him from speaking further.
He told broadcaster N-TV that people who saw the incident were "totally traumatised" and the street "looks a bit like after a war".
Leibe said he did not know the motive for the incident, which shocked residents of Germany's oldest town, founded by the Romans more than 2,000 years ago.
The Trierischer Volksfreund quoted an eyewitness as saying a Range Rover was driving at high speed and people had been thrown through the air. It said the car had Trier plates.
It reported that people screamed in panic when the car drove through the street.
Officers were scouring the area in search of evidence, backed by police dressed in flak jackets and carrying rifles. On the streets, Christmas lights twinkled incongruously.
Germany has tightened security on pedestrian zones across the country since a truck attack on a Berlin Christmas market in 2016 that killed 12 people and injured dozens.
In October 2019, a man opened fire on a synagogue in the city of Halle. After failing to get into the building he went on a rampage outside, killing two people.
In February this year a racist gunman killed nine migrants in Hanau near Frankfurt before killing his mother and himself. Only about a week later, a local man ploughed his car into a carnival parade in the town of Volkmarsen, injuring 61.
Germany has tightened measures to fight the coronavirus, with bars and restaurants closed, but shops and schools are still open.
"What happened in Trier is shocking. Our thoughts are with the relatives of the victims, with the numerous injured and with everyone who is currently on duty to care for the victims," Steffen Seibert, a spokesman for Chancellor Angela Merkel, said on Twitter.