COVID-19 mutations helping virus spread in humans: UK scientists

A police officer wears a thermal headgear to monitor the temperature of commuters in New Delhi. (Reuters)
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Updated 12 May 2020
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COVID-19 mutations helping virus spread in humans: UK scientists

  • The nature of COVID-19’s spike proteins are already thought to be the key reason why it was able to make the leap from a different species, widely thought to be bats, to humans in the first place

LONDON: UK scientists have suggested that COVID-19 may be mutating, heightening fears that the virus is adapting to being carried by humans.
In an unpublished study conducted by a team of researchers at the London School of Hygiene and Tropical Medicine, more than 5,300 coronavirus genomes were analyzed from samples taken from 62 countries.
The results of the study, which has not yet been peer-reviewed, found that one of two different spike protein mutations were found in 810 cases worldwide, with one in particular discovered in 788 cases.
The prevalence of the two mutations suggest that genetic changes in the makeup of the virus, specifically in the spike proteins that allow virus cells to latch on to and infect human cells, are a sign that COVID-19 is becoming more adept at passing from person to person. This could have far-reaching implications for how scientists develop vaccines and treatments.
The study added that spike protein mutations are relatively rare, and that mostly, COVID-19’s structure has remained stable throughout the pandemic.
It said though it is as yet unclear how the mutations the researchers have observed affect the disease’s ability to spread, the fact that the mutations are occurring independently across different regions suggests that they are playing at least some part in aiding transmission.
The study’s lead author, Martin Hibberd, professor of emerging infectious diseases at the London School of Hygiene and Tropical Medicine, said the findings are proof of the need to study the pathogen in case more dangerous mutations emerge.
“This is exactly what we need to look out for,” he added. “People are making vaccines and other therapies against this spike protein because it seems a very good target. We need to keep an eye on it and make sure that any mutations don’t invalidate any of these approaches.”
Part of what makes mutations in virus spike proteins significant, especially in the case of COVID-19, is that disrupting their function is one of the key lines of research in the quest to develop vaccines.
Major changes to these proteins through mutation, altering their behavior or potency, risk not only making the virus more aggressive as it evolves, but also undoing months of careful research into negating its effects on people.
The nature of COVID-19’s spike proteins are already thought to be the key reason why it was able to make the leap from a different species, widely thought to be bats, to humans in the first place.
It is also thought to be the reason why COVID-19 has proven to be a more contagious disease than the SARS coronavirus, which caused a smaller epidemic in Asia in 2002, on account of being better suited to interaction with human cells.
“This is an early warning,” Hibberd said. “Even if these mutations are not important for vaccines, other mutations might be, and we need to maintain our surveillance so we are not caught out by deploying a vaccine that only works against some strains.”


With Iran war exit elusive, Trump aides vie to affect outcome

Updated 13 sec ago
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With Iran war exit elusive, Trump aides vie to affect outcome

  • Aides debate when and how to declare victory even as the conflict spreads across the Middle East
  • In taking America to war, US President Donald Trump offered little explanation

WASHINGTON: A complex tug-of-war inside the White House is driving US President Donald Trump’s shifting public statements on the course of the Iran war, as aides debate when and how to declare victory even as the conflict spreads across the Middle East.

Some officials and advisers are warning Trump that surging gasoline prices could exact a political cost from the US-Israeli attacks on Iran, while some hawks are pressing the president to maintain the offensive against the Islamic Republic, according to interviews with a Trump adviser and others close to the deliberations.

Their observations to Reuters offer a previously unreported glimpse inside White House decision-making as it adjusts its approach to the biggest US military operation since the 2003 Iraq war.

Shifting messages, various internal viewpoints

The behind-the-scenes maneuvering underscores the high stakes Trump, who returned to office last year promising to avoid “stupid” military interventions, faces nearly two weeks after plunging the nation into a war that has rattled global financial markets and disrupted the international oil trade.

The jockeying for Trump’s ear is a feature of his presidency, but this time the consequences are a matter of war and peace in one of the world’s most volatile and economically critical regions.

Shifting from the sweeping goals he framed in launching the war on February 28, Trump in recent days has emphasized that he views the conflict as a limited campaign whose objectives have mostly been met.

But the message remains unclear to many, including the energy markets, which have lurched in both directions in response to Trump’s statements.

He told a campaign-style rally in Kentucky on Wednesday that “we won” the war, then abruptly pivoted: “We don’t want to leave early, do we? We’ve got to finish the job.”

Economic advisers and officials, including from the Treasury Department and the National Economic Council, have warned Trump that an oil shock and rising gasoline prices could quickly erode domestic support for the war, said the adviser and two others close to the deliberations, speaking on the condition of anonymity to disclose internal discussions.

Political advisers, including Chief of Staff Susie Wiles and deputy chief James Blair, are making similar arguments, focusing on the political fallout from higher gas prices and urging Trump to define victory narrowly and signal the operation is limited and nearly finished, the sources said.

Pushing in the other direction are hawkish voices urging Trump to sustain military pressure on Iran, including Republican lawmakers such as US Senators Lindsey Graham and Tom Cotton, and media commentators such as Mark Levin, according to people familiar with the matter.

They argue the US must prevent Iran from obtaining a nuclear weapon and respond forcefully to attacks on American troops and shipping.

A third force comes from Trump’s populist base and figures such as strategist Steve Bannon and right-wing television personality Tucker Carlson, who have been pressing him and his top aides to avoid getting dragged into another prolonged Middle East conflict.

“He is allowing the hawks to believe the campaign continues, wants markets to believe the war might end soon and his base to believe escalation will be limited,” the Trump adviser said.

Asked for comment, White House press secretary Karoline Leavitt said in a statement: “This story is based on gossip and speculation from anonymous sources who aren’t even in the room for any discussions with President Trump.

“The President is known for being a good listener and seeking the opinions of many people, but ultimately everyone knows he’s the final decision maker and his own best messenger,” she said. “The President’s entire team is focused on ensuring the objectives of Operation Epic Fury are fully achieved.”

Other people named for their roles in the deliberations did not immediately respond to Reuters’ questions.

Looking for an exit

In taking America to war, Trump offered little explanation, and the administration’s stated war aims have ranged from thwarting an imminent attack by Iran to crippling its nuclear program to replacing its government.

As he seeks an exit from an unpopular conflict, Trump is trying to juggle competing narratives that some critics say have complicated an already difficult situation, with Iran defiant despite the devastating US-Israeli air assault.

Top political aides and economic advisers, whose warnings before the war of the potential economic shock were largely ignored, appear to have played a major role in pushing Trump’s efforts this week to reassure skittish markets and contain rising oil and gas prices.

His public shift to downplaying the war’s impact, describing it as a “short-term excursion,” and his insistence that gas price hikes would be short-lived appeared aimed at calming fears of an open-ended conflict.

Some top aides have advised him to work toward a conclusion to the conflict that he can call a triumph, at least militarily, the sources said, even if much of the Iranian leadership survives, along with remnants of a nuclear program that the campaign was meant to target.

Wave after wave of US and Israeli air strikes have killed a number of top Iranian leaders among some 2,000 people overall – some as far away as Lebanon – devastated its ballistic missile arsenal, sunk much of its navy and degraded its ability to support armed proxies around the Middle East.

But the military achievements have been seriously undercut by Iran’s stepped-up attacks on oil tankers and transport facilities in the Gulf, driving up oil prices.

Trump has said he will decide when to end the campaign. He and his aides say they are far ahead of the four- to six-week timeframe Trump initially announced.

The shifting reasons for launching the conflict, which has spilled over into more than half a dozen other countries, have only made it more difficult to predict what comes next.

For their part, Iran’s rulers will claim victory, analysts say, for simply surviving the US-Israeli onslaught, especially after demonstrating their ability to fight back and inflict damage on Israel, the US and its allies.

Venezuela miscalculation

Critical to the war’s final trajectory will be the Strait of Hormuz. A fifth of the world’s oil shipments, which normally traverses the narrow waterway, has come to a near-standstill. Iran in recent days has struck tankers in Iraqi waters and other ships near the strait, and the new Supreme Leader Mojtaba Khamenei has vowed to keep it shut.

If Iran’s stranglehold on the waterway pushes US gas prices high enough, that could increase political pressure on Trump to end the military campaign to help his Republican Party, which is defending narrow majorities in Congress in November’s midterm elections.

Trump has recently refrained from pushing the idea that the war seeks to topple the government in Tehran. US intelligence indicates that Iran’s leadership is not at risk of collapse anytime soon, Reuters reported on Wednesday.

At least some of the confusion over the war’s trajectory appears rooted in the quick US military success in Venezuela.

Since the start of the war, some aides have struggled to convince Trump that the Iran campaign was unlikely to unfold in the same way as the January 3 Venezuela raid that captured President Nicolas Maduro, according to another source familiar with the administration’s thinking.

That operation opened the way for Trump to coerce former Maduro loyalists into giving him considerable sway over the country’s vast oil reserves – without requiring extended US military action.

Iran, by contrast, has proved a much tougher, better-armed foe with an entrenched clerical and security establishment.

Experts have rejected claims by Trump aides that Iran had been within weeks of being able to produce a nuclear weapon, despite the president’s insistence in June that US-Israeli bombing had “obliterated” its nuclear program.

Most of Iran’s stockpile of highly enriched uranium is believed to have been buried by the June strikes, meaning the material potentially could be retrieved and purified to bomb grade. Iran has always denied seeking nuclear weapons.

If the war drags on, American casualties mount and the economic costs multiply, some analysts say it could erode backing from Trump’s political base. But despite criticism from some supporters opposed to military interventions, members of his “Make America Great Again” movement have so far largely stayed with him on Iran.

“The MAGA base is going to give the president wiggle room,” said Republican strategist Ford O’Connell.