LONDON: British scientists have developed a far more accurate blood test to diagnose peanut allergy, offering a better way to monitor a significant food hazard.
Peanuts are the most common cause of fatal food-induced anaphylaxis, or severe allergic reaction, and allergy cases among children have risen sharply in recent years. Britain’s Food Standards Agency estimates up to one in 55 children have a peanut allergy.
In contrast to existing skin-prick and other blood tests that produce a large number of false positive results, the new diagnostic has 98 percent specificity, researchers from the Medical Research Council (MARC) reported on Thursday.
Current tests, in use for decades, are based on looking for antibodies — but they cannot differentiate between sensitivity and true food allergy.
As a result, doctors often have to conduct a further round of testing in which patients are fed incrementally larger doses of peanut in a controlled hospital setting to confirm their allergy, a process that can itself trigger anaphylactic shock.
So-called oral food challenges require the presence of an allergist and specialist nurses and they cost around £1,000 to conduct. The new blood test is five times cheaper.
Dr. Alexandra Santos, an MRC scientist and pediatric allergist at King’s College London, who led the research, believes the new test will not only save money on testing but also reduce by two-thirds the number of stressful oral food challenges that are needed.
The development of the new test follows advances in science that allow the detection of biological signals from much small blood samples than in the past.
“The technology has evolved. Now we have better ways to look at immune cells and to see how they respond,” Santos said.
The new tests focus on mast cells, which play a pivotal role in triggering allergic symptoms, such as skin reactions or constricting of the airways.
In a study involving 174 children, published in the Journal of Allergy and Clinical Immunology, Santos and colleagues showed the new test tracked closely the severity of allergies, with the worst-affected patients having the most activated mast cells.
The team is now discussing plans for the widespread roll-out of the test with an unnamed commercial partner. There are also plans to adapt it to other foods, such as milk, eggs, sesame and tree nuts.
There are currently no approved drugs for peanut allergies, although two biotech companies — US-based Aimmune Therapeutics and France’s DBV Technologies — are working to develop rival treatments.
Scientists devise new, more accurate peanut allergy test
Scientists devise new, more accurate peanut allergy test
- Current tests, in use for decades, are based on looking for antibodies — but they cannot differentiate between sensitivity and true food allergy
- The new tests focus on mast cells, which play a pivotal role in triggering allergic symptoms, such as skin reactions or constricting of the airways
Where We Are Going Today: Lahori Village
- While it is not a hard-and-fast rule, I often happily find that the simpler a restaurant presents itself to customers, the better the food
RIYADH: Sometimes it seems like the gaudiness of a restaurant’s interior is inversely proportional to the quality of the food.
That is why when I am dragged along to an eatery where the staff are dressed in ill-fitting waistcoats, where oversized chandeliers dangle precariously above diners, where faded tablecloths clash with faux vintage wallpaper, my expectations of enjoying a quality meal plummet.
While it is not a hard-and-fast rule, I often happily find that the simpler a restaurant presents itself to customers, the better the food.
These are my favorite kinds of restaurants, the ones that let the food speak for itself.
Lahori Village in Riyadh’s King Fahd district fits comfortably into this second category.
Though clean and comfortable, it is an unfussy establishment with few frills that does one thing very well: serve hearty, authentic and delicious Pakistani cuisine.
The mutton karahi is swimming in flavor — soft delectable chunks of meat in a rich sauce with a ginger tang.
The freshly baked garlic naan has a perfect hint of crunch giving way to soft dough perfect for soaking up a sauce.
The special fish barbecue is another highlight, with expertly balanced spice and sweetness.
Not every dish is available every day, so if you are after something in particular make sure to check the menu ahead of time.
But that limitation does not seem to put off customers, the place has been bustling with activity every time I have visited.
The cool kheer was a fantastic way to close off the meal — a light, sweet offering that leaves little to be desired.
And in a city rife with eye-watering prices, Lahori Village is a welcome respite, with the bill unlikely to upset most diners.
It is an all-round honest offering to the punters of Riyadh and well worth a visit.
