PARIS: A man whose body rejected a face transplant he received seven years ago has been given a second donor face after living nearly two months without one, French medical agencies said Friday.
It is the first time in transplant history that doctors have replaced one donor face with another, according to Olivier Bastien of France’s biomedicine agency.
More than 12 years since the first-ever face graft was done, in France, it remains a high-risk procedure.
A transplant can help recipients — often victims of accidents, violence, or rare genetic disorders — to resume basic tasks such as breathing, eating and speaking, and restores non-verbal communication through smiles and frowns.
But it also means a life-long reliance on immunosuppressant medicines, to stop the body rejecting the “foreign” organ. These drugs can leave a person vulnerable to infections and cancers.
It is a rare procedure with fewer than 40 operations performed to date, and at least six patients have died.
The latest recipient, in his 40s, went under the knife at a Paris hospital on Monday, for a procedure that lasted nearly a full day, according to a joint press statement issued by the biomedicine agency and the AP-HP public hospital system.
The man’s original graft had been removed in an operation on November 30, and he was kept on life support in an induced coma until the follow-up procedure.
“This graft shows for the first time... that re-transplantation is possible in the case of chronic rejection” of a donor face, said the statement.
It will be weeks before doctors can say whether the second graft has taken.
The recipient of the world’s first face transplant, Isabelle Dinoire, died of cancer in April 2016, 11 years after her groundbreaking operation.
Doctors said her body had rejected the transplant, and she had lost partial use of her lips by the time she died.
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Second face transplant for Frenchman in world-first
Second face transplant for Frenchman in world-first
Machado seeks Pope Leo’s support for Venezuela’s transition during Vatican meeting
- Machado is touring Europe and the United States after escaping Venezuela in early 2025
- The pope called for Venezuela to remain independent following the capture of former President Nicolás Maduro by US forces
ROME: Pope Leo XIV met with Venezuelan opposition leader and Nobel Peace Prize winner María Corina Machado in a private audience at the Vatican on Monday, during which the Venezuelan leader asked him to intercede for the release of hundreds of political prisoners held in the Latin American country.
The meeting, which hadn’t been previously included in the list of Leo’s planned appointments, was later listed by the Vatican in its daily bulletin, without adding details.
Machado is touring Europe and the United States after she reemerged in December after 11 months in hiding to accept her Nobel Peace Prize in Norway.
“Today I had the blessing and honor of being able to share with His Holiness and express our gratitude for his continued support of what is happening in our country,” Machado said in a statement following the meeting.
“I also conveyed to him the strength of the Venezuelan people who remain steadfast and in prayer for the freedom of Venezuela, and I asked him to intercede for all Venezuelans who remain kidnapped and disappeared,” she added.
Machado also held talks with Vatican Secretary of State Pietro Parolin, who was Nuncio in Venezuela from 2009 to 2013.
Pope Leo has called for Venezuela to remain an independent country after US forces captured former President Nicolás Maduro in his compound in Caracas and took him to New York to face federal charges of drug-trafficking.
Leo had said he was following the developments in Venezuela with “deep concern,” and urged the protection of human and civil rights in the Latin American country.
Venezuela’s opposition, backed by consecutive Republican and Democratic administrations in the US, had vowed for years to immediately replace Maduro with one of their own and restore democracy to the oil-rich country. But US President Donald Trump delivered them a heavy blow by allowing Maduro’s vice president, Delcy Rodríguez, to assume control.
Meanwhile, most opposition leaders, including Machado, are in exile or prison.
After winning the 2025 Nobel Prize for Peace, Machado said she’d like to give it to or share with Trump.
Machado dedicated the prize to Trump, along with the people of Venezuela, shortly after it was announced. Trump has coveted and openly campaigned for winning the Nobel Prize himself since his return to office in January 2025.
The organization that oversees the Nobel Peace Prize — the Norwegian Nobel Institute — said, however, that once it’s announced, the prize can’t be revoked, transferred or shared with others.
“The decision is final and stands for all time,” it said in a short statement last week.
The meeting, which hadn’t been previously included in the list of Leo’s planned appointments, was later listed by the Vatican in its daily bulletin, without adding details.
Machado is touring Europe and the United States after she reemerged in December after 11 months in hiding to accept her Nobel Peace Prize in Norway.
“Today I had the blessing and honor of being able to share with His Holiness and express our gratitude for his continued support of what is happening in our country,” Machado said in a statement following the meeting.
“I also conveyed to him the strength of the Venezuelan people who remain steadfast and in prayer for the freedom of Venezuela, and I asked him to intercede for all Venezuelans who remain kidnapped and disappeared,” she added.
Machado also held talks with Vatican Secretary of State Pietro Parolin, who was Nuncio in Venezuela from 2009 to 2013.
Pope Leo has called for Venezuela to remain an independent country after US forces captured former President Nicolás Maduro in his compound in Caracas and took him to New York to face federal charges of drug-trafficking.
Leo had said he was following the developments in Venezuela with “deep concern,” and urged the protection of human and civil rights in the Latin American country.
Venezuela’s opposition, backed by consecutive Republican and Democratic administrations in the US, had vowed for years to immediately replace Maduro with one of their own and restore democracy to the oil-rich country. But US President Donald Trump delivered them a heavy blow by allowing Maduro’s vice president, Delcy Rodríguez, to assume control.
Meanwhile, most opposition leaders, including Machado, are in exile or prison.
After winning the 2025 Nobel Prize for Peace, Machado said she’d like to give it to or share with Trump.
Machado dedicated the prize to Trump, along with the people of Venezuela, shortly after it was announced. Trump has coveted and openly campaigned for winning the Nobel Prize himself since his return to office in January 2025.
The organization that oversees the Nobel Peace Prize — the Norwegian Nobel Institute — said, however, that once it’s announced, the prize can’t be revoked, transferred or shared with others.
“The decision is final and stands for all time,” it said in a short statement last week.
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