DUBAI: US actress and producer Jessica Chastain sparkled in a purple jumpsuit by Lebanese designer Elie Saab at the Annual Breakthrough Prize Ceremony at the Academy Museum of Motion Pictures in Los Angeles.

Chastain — who has previously championed looks by Lebanon’s Zuhair Murad, among other Arab designers — hit the red carpet in the sequined number that boasted a plunging neckline and bootleg-style pants. Celebrity stylist Elizabeth Stewart finished off Chastain’s look with a statement necklace by Damiani jewelry.

French Canadian scientist Michel Sadelain was awarded an "Oscars of Science" for his research into genetically modifying immune cells to fight cancer at the event, AFP reported.

The genetic engineer was awarded the Breakthrough Prize at a glitzy ceremony attended by tech giants such as Elon Musk and Bill Gates, and an array of celebrities including Chastain, Robert Downey Jr. and Bradley Cooper.

His work has led to the development of a new form of therapy called CAR-T that has shown exceptional efficacy against certain blood cancers.

"This prize is an extraordinary recognition," Sadelain told AFP on the red carpet at the Oscars Museum. "It's all the more of an honor because ... my scientific colleagues told me for a long time that it would never work.

"The greatest pleasure, however, is to see patients... who no longer had a chance and who thank us, who are alive today thanks to CAR-T cells," added Sadelain.

Launched in 2010, the Breakthrough Prize awards "the world's most brilliant minds" in fields including life sciences, fundamental physics and mathematics, styling itself as the Silicon Valley-backed answer to the Nobels.

Dubbed the "Oscars for Science", founding sponsors include Sergey Brin, Priscilla Chan and Mark Zuckerberg.

Sadelain will split the $3 million prize money with American immunologist Carl June, who also led groundbreaking research into the field independently of his co-winner.

Sadelain studied medicine in Paris, then immunology in Canada, before taking up postdoctoral research at the Massachusetts Institute of Technology in 1989.

Other celebrity guests at the event includes actresses Zoe Saldana and Margot Robbie, director Olivia Wilde and Oscar-winner Michelle Yeoh, among others.

LONDON: To the Christians of Europe in the mid-15th century, the Islamic leader Mehmed II was “the terror of the world,” a “venomous dragon” at the head of “bloodthirsty hordes.”

The Roman Catholic Pope, Nicholas V, went even further. To him, the seventh ruler of the Ottoman Empire was nothing less than “the son of Satan, perdition and death.”

Understandably, Mehmed’s subjects felt rather differently about the man who between 1444 and 1481 would triple the size of the empire.

To them, he was “The Father of Conquest,” the man who in 1453, at the age of 21, achieved the impossible by capturing the supposedly impregnable fortress of Constantinople.

The single most strategically important city of the Middle Ages, Constantinople had been in Christian hands ever since its foundation in 330 AD by the Roman Emperor Constantine.

In modern-day Turkiye, Mehmed II is considered a hero by many. Symbolically, the Fatih Sultan Mehmet Bridge, which was completed in 1988 and links Europe and Asia across the Bosphorus Strait, bears his name.

Now, a unique and only recently rediscovered portrait of Mehmed the Conqueror, created an estimated three years before his most celebrated feat of arms, is coming up for sale at an auction at Bonhams of London, at which it is predicted to fetch as much as £2 million ($2.53 million).

This is far from being the only known portrait of Mehmed; one of the most famous, painted by the Venetian artist Gentile Bellini in about 1480, can be seen at the National Gallery in London.

The uniqueness of the likeness on the bronze medallion is that it is not only the only known portrait of Mehmed II as a young man, pictured before he conquered Constantinople, but also the earliest known portrait of any Islamic ruler by a Western artist.

There is no date on the medal. But the clue to when the portrait was executed — almost certainly from life, by a skilled but anonymous Renaissance artist — lies in the Latin inscription, which reads: “Great Prince and Great Emir, Sultan Master Mehmet.”

Tellingly, said Oliver White, Bonhams’ head of Islamic and Indian art, “the inscription lacks the ‘Imperatorial’ title, which was included on medals after the fall of Constantinople.”

Experts have also concluded that, because of the absence of any design or lettering on the reverse of the brass medallion, plus the existence of a hole at its top, through which a chain might have been attached, it could well have been “a deeply personal and significant possession of the great Sultan.”

This, said White, suggests the intriguing possibility that it might once have hung around the neck of The Conqueror as a talisman. Indeed, in a later portrait Mehmed is depicted wearing what appears to be the very same medal.

“For us, the single most important historical element is that we believe that the medal belonged personally to Mehmed,” said White.

“You can also say it was almost certainly done from life, that it is a real portrait that actually looks like him rather than being a typical generic miniature painting of a sultan.”

Although the name of the artist remains unknown, “we do know that it was made in Italy, because that’s where all these pieces were being made at the time, when it was a fairly new thing.

“The whole concept of these portrait medallions, which had been resurrected from ancient Rome, had begun only about 20 years earlier, in the 1430s.”

Presenting the fall of Constantinople as an existential struggle between Christianity and Islam would be to simplify a complex situation, said White. There were Turks among the defenders of Constantinople, loyal to the Byzantine Emperor Constantine XI, and thousands of Christians among the 50,000-strong Ottoman army.

In a short biography commissioned by Bonhams, historian Peter Frankopan writes that despite the portrayal of Mehmed in contemporary European propaganda as a tyrant, in fact “the conquest of Constantinople was accompanied by a set of policies that even critics conceded showed a surprising degree of tolerance, most notably to the Greek Orthodox Christians who were protected from persecution by laws as well as by the sultan’s personal command — with similar concessions being given to Armenian Christians, to Jews and to other minorities in the city.”

Nevertheless, the fall of the city, “which had been the subject of lavish investment by the Roman Emperor Constantine and had stood for more than a millennium as the capital of the Roman Empire in the east — usually called the Byzantine Empire — sent shockwaves through the Mediterranean and beyond.

“Constantinople’s fall to Mehmed and his forces was not so much a dramatic moment as a decisive turning point in history.”

In fact, according to the Victorian British historian Lord Acton, modern history began “under the stress of the Ottoman conquest.”

In Acton’s view, wrote Frankopan, “the failure of Europeans to put their differences to one side, the reluctance of Christians in the west to support their Greek-speaking Orthodox neighbours to the east, and the ineffective response to the threat posed by Mehmed and his Muslim armies set off a chain reaction that ultimately helped shape the Reformation — if not the age of global empires that emerged from places such as Spain, Portugal, the Netherlands and Britain.”

It was, said White, “no exaggeration to say that the fall of Constantinople shaped the modern world — and it was with the eventual collapse of the Ottoman Empire in the early 20th century that many of the problems of the modern world arose.”

In his relatively brief life — he died at the age of 49 in 1481 — Mehmed achieved much, including a series of further conquests in Asia and Europe. But although he carved his way through much of the 15th century with a sword, he was a man of contradictions, introducing many political and social reforms at home and proving a great patron of the arts and sciences.

“He gathered Italian humanists and Greek scholars to his court,” said White, “and by the end of his reign had transformed Constantinople into a thriving imperial capital.”

Although Mehmed commissioned many portraits of himself during his reign, executed in the Italian style, it is the rarity of the medallion that has invested it with such a high potential value.

“The medal was acquired by its present owner in an auction in Rome in 2000,” said White. “It was lumped in with a job lot of medals, and considered to be of very little importance.”

At the time no one quite understood its significance. A lot of academics have looked at it, and for seven or eight years after the original sale it was thought it might date to the 1460s, which was post-Constantinople and therefore less.”

Finally, it was realized that Mehmed had been referred to by the Latin title “Magnus princeps” only once before — in a treaty with Venice, drawn up in the 1440s.

In all portraits and references following the 53-day siege of 1453 he is referred to without exception as “The Conqueror of Constantinople.”

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The unnamed owner is now parting with the medal after the successful completion of two decades of research into its history.

“It’s been his baby for 25 years,” said White, “and I think he feels, ‘we know what it is now, and it's time for the public to enjoy it’.”

There is, of course, no guarantee that the medal will be purchased by an institution, said White. But the expected price and the historical significance of the piece in the story of Islam suggests at least “the possibility” that bidders will include some of the great museums of the Middle East.

Bidding will have to be furious to beat the world record for an Islamic and Indian object, set by the sale in London last year of the sword of Tipu Sultan, ruler of the Kingdom of Mysore in southern India between 1782 and 1799, for £14 million.

The Mehmed medallion, estimated at between £1.5-2 million, will be the star lot at the Bonhams Islamic and Indian Art Sale on May 21 at Bonhams New Bond Street, London.