Coronavirus mutation ‘of most concern’ has occurred spontaneously in UK variant

Police volunteers distribute coronavirus testing kits in the Goldsworth Park and St John's suburbs of Woking in Surrey, southwest of London, on February 2, 2021 as testing for the South African variant of Covid-19 is increased. (AFP)
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Updated 02 February 2021
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Coronavirus mutation ‘of most concern’ has occurred spontaneously in UK variant

LONDON: The coronavirus mutation “of most concern” that could impact vaccine efficacy has occurred spontaneously in the UK variant, a professor of outbreak medicine who is part of a panel that advises the British government said on Tuesday.
The E484K mutation, which occurs on the spike protein of the virus, is the same change as has been seen in the South African and Brazilian variants that have caused international concern.
Several laboratory studies have found that vaccines and antibody therapy are less effective against the South African variant.
By contrast, early evidence showed that vaccines worked just as well against the UK variant, called B.1.1.7, which originally did not have the E484K mutation.
“The mutation of most concern, which we call E484K, has also occurred spontaneously in the new Kent strain in parts of the country too,” said Calum Semple, a member of the Scientific Advisory Group for Emergencies, on BBC radio, referring to the southern English county where the UK variant was first detected.

Concern over the South African variant has prompted authorities in England to begin a door-to-door mass testing drive targeting 80,000 people living in areas where cases of the variant have been found in people with no link to South Africa.
The fact that the E484K mutation had occurred spontaneously in Britain had already been reported in a technical briefing published by Public Health England, but this had not been widely noticed outside scientific circles.
The report said the mutation had been detected in 11 B.1.1.7 genomes, possibly as a result of “more than one acquisition event,” suggesting that the 11 genomes were not all linked to each other and the mutation may have occurred spontaneously at separate locations.
The name E484K, in layman’s terms, is like map coordinates. The number 484 is the exact location of the mutation, the letter E is the amino acid that it was originally and the letter K is the amino acid that it has mutated to.
“Unfortunately, the lack of control of these different variants in the UK may lead this population to become a melting pot for different emerging SARS-COV-2/COVID-19 variants,” said Julian Tang, a virologist at the University of Leicester.


Ukraine’s Zelensky meets Pope Leo, prepares revised plan on Russia war

Updated 58 min 42 sec ago
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Ukraine’s Zelensky meets Pope Leo, prepares revised plan on Russia war

  • UKrainian leader said that Washington’s 28-point plan had been reduced to 20 points after US-Ukraine talks at the weekend

CASTEL GANDOLFO, Italy: Ukrainian President Volodymyr Zelensky met with Pope Leo XIV in Italy on Tuesday as he prepared to send the United States revised proposals to end Russia’s invasion.
Zelensky on Monday held talks with European leaders in London and Brussels as US President Donald Trump keeps up pressure on Kyiv for a settlement.
Trump has accused Zelensky of not even reading his administration’s initial proposals, which were judged by Ukraine’s allies to be overly favorable to Russia.
Zelensky said that Washington’s 28-point plan had been reduced to 20 points after US-Ukraine talks at the weekend.
Ukrainian and European officials “are going to work on these 20 points,” Zelensky told an online press conference on Monday.
“We do not like everything that our partners came back with. Although this issue is not so much with the Americans as with the Russians.
“But we will definitely work on it, and as I said, tomorrow evening (Tuesday) we will do everything to send our view on this to the US.”
Washington’s plan involved Ukraine surrendering land that Russia has not captured in return for security promises that fall short of Kyiv’s aspirations to join NATO.
Zelensky pointed to the land issue and international security guarantees as two of the main sticking points.
“Do we envision ceding territories? We have no legal right to do so, under Ukrainian law, our constitution and international law. And we don’t have any moral right either,” Zelensky said.
“The key is to know what our partners will be ready to do in the event of new aggression by Russia. At the moment, we have not received any answer to this question,” Zelensky said.
‘Robust security guarantees’
Zelensky met with Pope Leo at his country residence in Castel Gandolfo near Rome, and is to meet Italian Prime Minister Giorgia Meloni later Tuesday.
Meloni has been a staunch supporter of Kyiv since Russia’s February 2022 invasion, although one of her coalition allies, Matteo Salvini’s League party, is more skeptical.
Rome has sent weapons to Ukraine but only for use inside the country. Meloni has also ruled out sending troops in a possible monitoring force proposed by Britain and France.
The Italian government last week postponed a decision on renewing military aid to Ukraine, with the current authorization due to end on December 31. Salvini has reportedly questioned if it was necessary given the new talks.
However, Meloni at the time insisted that “as long as there’s a war, we’ll do what we can, as we’ve always done to help Ukraine defend itself.”
On Monday, Zelensky met in London with the leaders of Britain, France and Germany before heading to Brussels for talks with the heads of the EU and of NATO.
“Ukraine’s sovereignty must be respected. Ukraine’s security must be guaranteed, in the long term, as a first line of defense for our Union,” European Commission President Ursula von der Leyen said after Monday’s meeting.
French President Emmanuel Macron wrote on X after the London meeting that “we are preparing robust security guarantees and measures for Ukraine’s reconstruction.”
Macron said the “main issue” was finding “convergence” between the European-Ukrainian position and that of the United States.
Trump has blown hot and cold on Ukraine since returning to office in January, initially chastising Zelensky for not being grateful for US support.
But he was also frustrated that efforts to persuade Russian President Vladimir Putin to end the war had failed to produce results and he recently slapped sanctions on Russian oil firms.