TEHRAN: The first study of the safety and effectiveness of a coronavirus vaccine in Iran began Tuesday, state TV reported, with dozens due to receive the domestically developed shot in the hardest-hit country in the Middle East.
The vaccine, produced by Shifa Pharmed, part of a state-owned pharmaceutical conglomerate, is the first in the country to reach human trials. President Hassan Rouhani has said Iran is cooperating with a “foreign country” to produce another vaccine expected to run in tests in human volunteers in February, without offering further details.
Iran has struggled to stem the worst virus outbreak in the region, which has infected over 1.2 million people and killed nearly 55,000.
The study, a Phase 1 clinical trial, will enroll a total of 56 volunteers to receive two shots of Iran’s vaccine within two weeks, according to Hamed Hosseini, a clinical trial manager, with results to be announced roughly a month after the second shot. Three people received the first injections on Tuesday at a ceremony at a Tehran hotel attended by the country’s health minister. Authorities expect to the vaccine to hit the market by late spring 2021.
“I am happy that the scientific process went ahead in a proper way,” said Tayebeh Mokhber, daughter of the Barekat Pharmaceutical Group chairman, who was the first to get jabbed. “I hope the conclusion will be health for our people.”
The treatment, dubbed Coviran, is a so-called inactivated vaccine, meaning that it is made of a coronavirus that has been weakened or killed by chemicals, similar to how polio immunizations are made. Leading Western vaccines, like the shot made by Pfizer and its German partner BioNTech, use newer, less-proven technology to target the coronavirus’ spike protein using RNA.
Still, with progress slow in Iran’s vaccine research as Western countries grant approval for emergency use of vaccines and kick off mass inoculation campaigns, Iranian authorities have stressed the need to import vaccines.
Iranian authorities have repeatedly alleged that tough American sanctions undermine their efforts to purchase foreign-made vaccines and inoculate their citizens. US sanctions do have specific carve-outs for medicine and humanitarian aid to Iran. However, international banks and financial institutions hesitate in dealing with Iran transactions for fear of being fined or locked out of the American market.
Iran retains routes to imported vaccines, including through COVAX, an international program designed to distribute coronavirus vaccines to participating countries around the world. On Monday, Iran said it expects a group of US-based benefactors to ship thousands of Pfizer coronavirus vaccine in the coming weeks.
Iran begins first human trial of locally made virus vaccine
Iran begins first human trial of locally made virus vaccine
- The vaccine is produced by Shifa Pharmed, part of a state-owned pharmaceutical conglomerate
- The study, a Phase 1 clinical trial, will enroll a total of 56 volunteers to receive two shots of Iran’s vaccine within two weeks
Israel’s settler movement takes victory lap as a sparse outpost becomes a settlement within a month
- Smotrich, who has been in charge of Israeli settlement policy for the past three years, has overseen an aggressive construction and expansion binge aimed at dismantling any remaining hopes of establishing a Palestinian state in the occupied West Bank
YATZIV SETTLEMENT, West Bank: Celebratory music blasting from loudspeakers mixed with the sounds of construction, almost drowning out calls to prayer from a mosque in the Palestinian town across this West Bank valley.
Orthodox Jewish women in colorful head coverings, with babies on their hips, shared platters of fresh vegetables as soldiers encircled the hilltop, keeping guard.
The scene Monday reflected the culmination of Israeli settlers’ long campaign to turn this site, overlooking the Palestinian town of Beit Sahour, into a settlement. Over the years, they fended off plans to build a hospital for Palestinian children on the land, always holding tight to the hope the land would one day become theirs.
That moment is now, they say.
Smotrich goes on settlement spree
After two decades of efforts, it took just a month for their new settlement, called “Yatziv,” to go from an unauthorized outpost of a few mobile homes to a fully recognized settlement. Fittingly, the new settlement’s name means “stable” in Hebrew.
“We are standing stable here in Israel,” Finance Minister and settler leader Bezalel Smotrich told The Associated Press at Monday’s inauguration ceremony. “We’re going to be here forever. We will never establish a Palestinian state here.”
With leaders like Smotrich holding key positions in Israel’s government and establishing close ties with the Trump administration, settlers are feeling the wind at their backs.
Smotrich, who has been in charge of Israeli settlement policy for the past three years, has overseen an aggressive construction and expansion binge aimed at dismantling any remaining hopes of establishing a Palestinian state in the occupied West Bank.
While most of the world considers the settlements illegal, their impact on the ground is clear, with Palestinians saying the ever-expanding construction hems them in and makes it nearly impossible to establish a viable independent state. The Palestinians seek the West Bank, captured by Israel in 1967, as part of a future state.
With Netanyahu and Trump, settlers feel emboldened
Settlers had long set their sights on the hilltop, thanks to its position in a line of settlements surrounding Jerusalem and because they said it was significant to Jewish history. But they put up the boxy prefab homes in November because days earlier, Palestinian attackers had stabbed an Israeli to death at a nearby junction.
The attack created an impetus to justify the settlement, the local settlement council chair, Yaron Rosenthal, told AP. With the election of Israel’s far-right government in late 2022, Trump’s return to office last year and the November attack, conditions were ripe for settlers to make their move, Rosenthal said.
“We understood that there was an opportunity,” he said. “But we didn’t know it would happen so quickly.”
“Now there is the right political constellation for this to happen.”
Smotrich announced approval of the outpost, along with 18 others, on Dec. 21. That capped 20 years of effort, said Nadia Matar, a settler activist.
“Shdema was nearly lost to us,” said Matar, using the name of an Israeli military base at the site. “What prevented that outcome was perseverance.”
Back in 2006, settlers were infuriated upon hearing that Israel’s government was in talks with the US to build a Palestinian children’s hospital on the land, said Hagit Ofran, a director at Peace Now, an anti-settlement watchdog group, especially as the US Agency for International Development was funding a “peace park” at the base of the hill.
The mayor of Beit Sahour urged the US Consulate to pressure Israel to begin hospital construction, while settlers began weekly demonstrations at the site calling on Israel to quash the project, according to consulate files obtained through WikiLeaks.
It was “interesting” that settlers had “no religious, legal, or ... security claim to that land,” wrote consulate staffer Matt Fuller at the time, in an email he shared with the AP. “They just don’t want the Palestinians to have it — and for a hospital no less — a hospital that would mean fewer permits for entry to Jerusalem for treatment.”
The hospital was never built. The site was converted into a military base after the Netanyahu government came to power in 2009. From there, settlers quickly established a foothold by creating makeshift cultural center at the site, putting on lectures, readings and exhibits
Speaking to the AP, Ehud Olmert, the Israeli prime minister at the time the hospital was under discussion, said that was the tipping point.
“Once it is military installation, it is easier than to change its status into a new outpost, a new settlement and so on,” he said.
Olmert said Netanyahu — who has served as prime minister nearly uninterrupted since then — was “committed to entirely different political directions from the ones that I had,” he said. “They didn’t think about cooperation with the Palestinians.”
Palestinians say the land is theirs
The continued legalization of settlements and spiking settler violence — which rose by 27 percent in 2025, according to Israel’s military — have cemented a fearful status quo for West Bank Palestinians.
The land now home to Yatziv was originally owned by Palestinians from Beit Sahour, said the town’s mayor, Elias Isseid.
“These lands have been owned by families from Beit Sahour since ancient times,” he said.
Isseid worries more land loss is to come. Yatziv is the latest in a line of Israeli settlements to pop up around Beit Sahour, all of which are connected by a main highway that runs to Jerusalem without entering Palestinian villages. The new settlement “poses a great danger to our children, our families,” he said.
A bypass road, complete with a new yellow gate, climbs up to Yatziv. The peace park stands empty.










