Researchers begin trials of COVID-19 vaccine

In this file photo taken on February 10, 2020 Doctor Paul McKay, who is working on an vaccine for the 2019-nCoV strain of the novel coronavirus poses for a photograph using a pipette expresses coronavirus onto surface protein to apply cell cultures, in a research lab at Imperial College School of Medicine (ICSM) in London on February 10, 2020. (AFP)
Short Url
Updated 23 May 2020
Follow

Researchers begin trials of COVID-19 vaccine

  • Oxford group could have 1 million doses ready by September if successful
  • The trial, now in its second phase following preliminary testing on a small sample size of 160 patients, will involve people of all age demographics

LONDON: A team of researchers has begun recruiting volunteers for clinical trials of a vaccine against COVID-19, while another team has started work on a treatment that may help critically ill patients recover from the disease.

Research at the Jenner Institute at Oxford University, carried out in conjunction with an organization called the Oxford Vaccine Group, has been ongoing since January, with scientists now looking to recruit in excess of 10,000 people to take part in further trials following preliminary efforts in April.
The trial, now in its second phase following preliminary testing on a small sample size of 160 patients, will involve people of all age demographics — from children older than 5 years to the elderly — to help test the effectiveness of the vaccine, called ChAdOx1 nCoV-19, in a wider variety of people.
The vaccine — which was developed using an altered virus that affects chimpanzees, combined with the virus that causes COVID-19 in humans, SARS-CoV-2 — had positive effects in animal trials.
It will now be given to subjects alongside a licensed vaccine, MenACWY, which is used to combat meningitis and blood poisoning, which will serve as a “control comparison.”
It is one of only four major vaccine trials currently taking place worldwide, though over 100 experimental vaccines are known to be in development.
The head of the Oxford Vaccine Group, Prof. Andrew Pollard, said: “The clinical studies are progressing very well, and we are now initiating studies to evaluate how well the vaccine induces immune responses in older adults, and to test whether it can provide protection in the wider population.”
Preparation for mass production of the vaccine is already underway in anticipation of the trial proving successful.
The Oxford team has said it expects to have around a million units of the vaccine ready for use by September should that prove to be the case.
This week, pharmaceutical giant AstraZeneca said it had the capacity to make a billion doses of the Oxford vaccine, and had secured an agreement to produce at least 400 million doses.
Meanwhile, scientists working at King’s College, London, as well as the city’s Francis Crick Institute and Guy’s and St. Thomas’ Hospital, have started clinical trials of a drug called interleukin 7 to test its effects on combating COVID-19.
Interleukin 7 is known to boost a certain kind of human immune system cell, known as a T-cell, which is vital for clearing the body of infection.
A common theme among particularly serious cases of COVID-19 is a low T-cell count, though it is not yet known why. It is hoped that the introduction of the drug to patients suffering low counts may aid their recovery. The Crick Institute’s Prof. Adrian Hayday said: “They (the T-cells) are trying to protect us, but the virus seems to be doing something that’s pulling the rug from under them, because their numbers (in tested patients) have declined dramatically.”
The team believes that as well as boosting T-cell levels in critical patients, the findings of the trial may help develop a “fingerprint test” to check T-cell levels in the blood, which could help identify at an early stage patients at risk of developing more critical symptoms.
The team also hopes it will lead to the development of a treatment specifically aimed at reversing the effects of T-cell decline in COVID-19 patients.
“The virus that has caused this completely earth-changing emergency is unique — it’s different. It is something unprecedented,” said Hayday. “This virus is really doing something distinct, and future research — which we will start immediately — needs to find out the mechanism by which this virus is having these effects.”


Human rights situation in Colombia is backsliding, UN warns as nation heads into elections

Updated 2 sec ago
Follow

Human rights situation in Colombia is backsliding, UN warns as nation heads into elections

The annual report on Colombia’s human rights situation highlights a surge in attacks on rural communities by rebel groups and drug traffickers
Murders of human rights defenders increased by 9 percent last year

BOGOTA: Colombia is at risk of “reverting to the serious human rights situation” it faced before a peace deal with the nation’s largest rebel group improved security conditions, the United Nations warned Thursday, adding that an uptick of violence in rural areas could also “undermine” the nation’s upcoming elections.
The annual report on Colombia’s human rights situation highlights a surge in attacks on rural communities by rebel groups and drug traffickers as they fight over territory abandoned by the Revolutionary Armed Forces of Colombia following their 2016 peace deal with Colombia’s government.
According to the report, the number of people displaced by violence in Colombia increased by 85 percent in 2025 from the year before, with approximately 94,000 people forced to flee their homes.
Murders of human rights defenders increased by 9 percent last year alongside a 12 percent increase in the number of lockdowns imposed by armed groups on rural communities. During the lockdowns, villagers are banned from hunting or tending to their farms. Schools and businesses are also forced to shut down in small towns, disrupting the livelihoods of civilians.
“This report is an early warning,” said Scott Campbell, the Colombia representative for the United Nations High Commissioner for Human Rights. “There are a number of indicators that we are trying to draw attention to in order to prevent further degradation” of the human rights situation in Colombia.
While human rights violations in Colombia are not as numerous as they were at the height of the nation’s conflict with the FARC rebels — when an average of 300,000 people were displaced by violence each year — the report says that Colombia’s government has to take firmer actions to protect civilians from illegal groups.
One problem that persists is the forced recruitment of children by rebel groups that now use social media platforms to lure kids into their ranks.
Although the UN confirmed 150 cases of forced recruitment in 2025, the report notes this is likely an undercount, because many families are afraid to denounce these cases for fear of retaliation.
The administration of left-wing President Gustavo Petro, a former member of Colombia’s M-19 guerrilla group, has tried to reduce violence in Colombia by staging peace negotiations with the nation’s remaining rebel groups under a strategy known as “total peace.”
But often, the report notes, ceasefires between the Colombian government and rebel groups have failed to reduce attacks on civilians.
“We think it is very important that the government push for remedies to that,” Campbell said.
As Colombia prepares for upcoming elections, the report warns of a risky environment for political candidates. Last year alone, there were 18 murders of political leaders in Colombia and 126 attacks against them.
In June, conservative presidential hopeful Miguel Uribe was shot in the head during a rally in Bogota, marking the first attack against a Colombian presidential candidate in three decades. Uribe died from his injuries two months later.
“Violence and conflict, including the emergence of pre-electoral violence, have generated greater risks for the free and safe exercise of certain civil and political rights” the report said.
On March 8, Colombia will elect a new Senate and House of Representatives, with candidates competing to fill more than 300 congressional seats.
That will be followed up by a presidential election in May, in which at least half a dozen candidates are expected to run.
To improve the human rights situation in Colombia, the report said that the next administration must focus on the full implementation of the 2016 peace pact with FARC rebels.
While some parts of the deal have been implemented — including the FARC’s disarmament and the creation of a transitional justice system — others remain unfulfilled.
One of those is the creation of an agrarian jurisdiction to resolve conflicts over land. Schemes that could lure farmers away from growing coca, the base ingredient for cocaine, also require further implementation.
“It’s crucially important at this juncture ahead of elections to make sure that the current government and the future government take concrete actions to make sure that Colombia moves forward,” Campbell said.
He added that the 2016 peace deal provides a “road map” to a “Colombia of sustainable peace and respect for human rights.”