MIAMI, USA: People who are genetically predisposed to storing belly fat, or having an apple-shaped body type, could face a higher risk of type 2 diabetes and heart disease, researchers said Tuesday.
The study in the Journal of the American Medical Association (JAMA) suggests a person’s genetic makeup may cause health problems down the road.
“People vary in their distribution of body fat — some put fat in their belly, which we call abdominal adiposity, and some in their hips and thighs,” said senior author Sekar Kathiresan, associate professor of Medicine at Harvard Medical School.
“We tested whether genetic predisposition to abdominal adiposity was associated with the risk for type 2 diabetes and coronary heart disease and found that the answer was a firm ‘yes’.”
Previous observational studies have uncovered a link between belly fat and type 2 diabetes and heart disease, but fell short of proving cause and effect.
To investigate further, researchers examined six studies conducted from 2007 to 2015, including some 400,000 participants whose genomes were analyzed.
Previous research had identified 48 gene variants associated with waist-to-hip ratio, resulting in a genetic risk score.
They found that people with certain genes that predisposed them to higher waist-to-hip ratio also had higher lipids, insulin, glucose and systolic blood pressure, as well as a higher risk for type 2 diabetes and heart disease.
“These results illustrate the power of using genetics as a method of determining the effects of a characteristic like abdominal adiposity on cardiometabolic outcomes,” said lead author Connor Emdin, a researcher at Massachusetts General Hospital.
Since researchers did not find any links between body type, genetic risk score and confounding factors such as diet and smoking, that “provides strong evidence that abdominal adiposity itself contributes to causing type 2 diabetes and heart disease,” he added.
Emdin said the findings could one day lead to the development of drugs designed to target belly fat, and perhaps lower the risk of diabetes and heart disease.
'Apple-shaped' body could raise risk of diabetes
'Apple-shaped' body could raise risk of diabetes
Where We Are Going Today: Zeila in Riyadh
- If you want an Instagrammable dish, check out the breakfast garden — multigrain sourdough topped with beetroot cream and a bed of avocados, edamame and peas, served with poached eggs and hollandaise sauce
As far as breakfast spots go, Riyadh’s main districts have some decent choices. But head east, and you will find a hidden gem in Al-Hamra you should not miss.
We recently discovered Zeila — somewhere that offers great food options without the wait times.
We started with the Croque Madame — a fried egg with hollandaise sauce atop toasted multigrain sourdough bread, served open-faced with smoked turkey, Emmental cheese, Dijon mustard cream and melted mozzarella. The well-balanced flavors come together smoothly without feeling too heavy for breakfast.
The shakshuka is another strong choice. This wholesome Zeila signature dish features confit bell peppers in olive oil, spicy cumin-tomato sauce, and comes topped with two poached eggs and coriander. It is served with multigrain sourdough.
If you want an Instagrammable dish, check out the breakfast garden — multigrain sourdough topped with beetroot cream and a bed of avocados, edamame and peas, served with poached eggs and hollandaise sauce.
On the heartier side, the mouthwatering selection of egg dishes includes a ribs Benedict, carbonara croissant, and a black truffle Benedict.
We couldn’t leave our sweet tooth hanging, so we opted for the Russian pancakes for a sweet, yet not overly so, ending to the meal.
But there are more innovative dishes, such as the Om Ali, which is prepared with freshly toasted croissant slices soaked in a mixture of milk and cream, complemented with a selection of nuts and locally made fresh cream. There is also a creme brulee crepe, or banoffee French toast made with salted caramel and grilled banana, served with vanilla ice cream.
The service was great, though the plastic utensils provided were disappointing.
However, Zeila’s interior is what really makes the trip worthwhile. The space, warm with natural light from the high glass walls, is spacious yet retains a comfortable ambience.
Adorned with hammock swing chairs, cozy leather couches, an outdoor seating area and luscious plants, it’s a great place to explore this winter whether you’re looking for a full meal or a cup of coffee while you do some work.
