Scientists unlock gene secrets of opium poppy drug

Updated 08 July 2012
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Scientists unlock gene secrets of opium poppy drug

LONDON: Scientists have unraveled exactly how opium poppies produce a non-addictive compound that can both suppress coughs and kill tumor cells, paving the way for improved production of the medicine.
Opium poppies, the source of illicit heroin, are also important for producing medical painkillers such as morphine and codeine, along with noscapine, which has been used for decades as a cough suppressant.
More recently, researchers have found noscapine is also a potent anti-cancer agent, prompting clinical tests into its role in fighting blood cancer.
The discovery that a cluster of 10 genes is responsible for the synthesis of noscapine inside the poppies means plant breeders can now develop high-yielding varieties. It may also help scientists in future produce the drug in factories.
The findings by researchers at the University of York and GlaxoSmithKline were published on Thursday in the journal Science.
British-based GSK is a leading producer of opium-based ingredients, supplying around 20 percent of the world’s medicinal opiate needs from poppies grown by farmers in Tasmania.
The fact that all the genes associated with noscapine are clustered together makes life much easier for plant breeders who can use the information to develop high-yielding commercial noscapine poppies.
In contrast to illegal opium production in countries like Afghanistan, where harvesting is done by hand by lancing poppy heads, commercial pharmaceutical production is highly mechanized, with farmers using modern combine harvesters.
That makes commercial poppy cultivation a cost-effective process, even though most medicines today are produced by chemical synthesis or biotechnology.
“The poppy plant is very efficient at producing these compounds,” said Ian Graham, director of the Center for Novel Agricultural Products at York.
Working back from a strain of poppies producing high levels of noscapine, Graham and colleagues followed the trail of genes linked to the chemical to home in on the cluster of 10 specific genes central to production of the compound.
The cluster of genes, all of which are inherited together, is the most complex ever found in plants.
Noscapine was first discovered in the early 19th century and has been used to suppress coughs since the 1950s, but interest in the compound has grown since 1998 when scientists demonstrated that it acts as a potent anti-tumor agent.
It functions in a similar way to Taxol, a cancer drug originally isolated from the bark of the Pacific yew tree and commercialized by Bristol-Myers Squibb.
Cougar Biotechnology, now part of Johnson & Johnson, has been studying noscapine as a treatment for multiple myeloma, a type of cancer affecting the plasma cells in bone marrow.

 


Harvey Weinstein’s rape conviction is overturned by New York’s top court

Updated 13 min 26 sec ago
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Harvey Weinstein’s rape conviction is overturned by New York’s top court

  • The court found the trial judge unfairly allowed testimony against Weinstein based on allegations that weren’t part of the case
  • The 72-year-old ex-movie mogul, however, will remain in prison because he was convicted in Los Angeles in 2022 of another rape

NEW YORK: New York’s highest court on Thursday threw out Harvey Weinstein ‘s 2020 rape conviction with a ruling that shocked and disappointed women who celebrated historic gains during the #MeToo era and left those who testified in the case bracing for a retrial against the ex-movie mogul.
The court found the trial judge unfairly allowed testimony against Weinstein based on allegations that weren’t part of the case.
Weinstein, 72, will remain in prison because he was convicted in Los Angeles in 2022 of another rape. But the New York ruling reopens a painful chapter in America’s reckoning with sexual misconduct by powerful figures — an era that began in 2017 with a flood of allegations against Weinstein.
#MeToo advocates noted that Thursday’s ruling was based on legal technicalities and not an exoneration of Weinstein’s behavior, saying the original trial irrevocably moved the cultural needle on attitudes about sexual assault.
The Manhattan district attorney’s office said it intends to retry Weinstein, and at least one of his accusers said through her lawyer that she would testify again.

Former film producer Harvey Weinstein appears in court at the Clara Shortridge Foltz Criminal Justice Center in Los Angeles, California, on October 4, 2022. (Pool via REUTERS/File Photo)

The state Court of Appeals overturned Weinstein’s 23-year sentence in a 4-3 decision, saying “the trial court erroneously admitted testimony of uncharged, alleged prior sexual acts” and permitted questions about Weinstein’s “bad behavior” if he had testified. It called this “highly prejudicial” and “an abuse of judicial discretion.”
In a stinging dissent, Judge Madeline Singas wrote that the Court of Appeals was continuing a “disturbing trend of overturning juries’ guilty verdicts in cases involving sexual violence.” She said the ruling came at “the expense and safety of women.”
In another dissent, Judge Anthony Cannataro wrote that the decision was “endangering decades of progress in this incredibly complex and nuanced area of law” regarding sex crimes after centuries of “deeply patriarchal and misogynistic legal tradition.”
The reversal of Weinstein’s conviction is the second major #MeToo setback in the last two years. The US Supreme Court refused to hear an appeal of a Pennsylvania court decision to throw out Bill Cosby’s sexual assault conviction.
Weinstein has been in a New York prison since his conviction for forcibly performing oral sex on a TV and film production assistant in 2006, and rape in the third degree for an attack on an aspiring actor in 2013. He was acquitted on the most serious charges — two counts of predatory sexual assault and first-degree rape.
He was sentenced to 16 years in prison in the Los Angeles case.

Caption

Weinstein’s lawyers expect Thursday’s ruling to have a major impact on the appeal of his Los Angeles rape conviction. Their arguments are due May 20.
Jennifer Bonjean, a Weinstein attorney, said the California prosecution also relied on evidence of uncharged conduct alleged against him.
“A jury was told in California that he was convicted in another state for rape,” Bonjean said. “Turns out he shouldn’t have been convicted and it wasn’t a fair conviction. … It interfered with his presumption of innocence in a significant way in California.”
Weinstein lawyer Arthur Aidala called the Court of Appeals ruling “a tremendous victory for every criminal defendant in the state of New York.”
Attorney Douglas H. Wigdor, who has represented eight Harvey Weinstein accusers including two witnesses at the New York criminal trial, called it “a major step back” and contrary to routine rulings by judges allowing evidence of uncharged acts to help jurors understand the intent or patterns of a defendant’s criminal behavior.
Debra Katz, a prominent civil rights and #MeToo attorney who represented several Weinstein accusers, said her clients are “feeling gutted” by the ruling, but she believes — and is telling them — that their testimony had changed the world.
“People continue to come forward, people continue to support other victims who’ve reported sexual assault and violence, and I truly believe there’s no going back from that,” Katz said. She predicted Weinstein will be convicted at a retrial and said accusers like her client Dawn Dunning feel great comfort knowing he will remain behind bars.
Dunning, a former actor who was a supporting witness at the New York trial, said in remarks to The Associated Press conveyed through Katz that she was “shocked” by the ruling and dealing with a range of emotions, including asking herself, “Was it all for naught?”
“It took two years of my life,” Dunning said. “I had to live through it every day. But would I do it again? Yes.”
She said that in confronting Weinstein, she faced her worst fear and realized he had no power over her.
Weinstein’s conviction in 2020 was heralded by activists and advocates as a milestone achievement, but dissected just as quickly by his lawyers and, later, the Court of Appeals when it heard arguments on the matter in February.
Allegations against Weinstein, the once powerful and feared studio boss behind such Oscar winners as “Pulp Fiction” and “Shakespeare in Love,” ushered in the #MeToo movement.
Dozens of women came forward to accuse Weinstein, including stars such as Ashley Judd and Uma Thurman. His New York trial drew intense publicity, with protesters chanting “rapist” outside the courthouse.
“This is what it’s like to be a woman in America, living with male entitlement to our bodies,” Judd said Thursday.
Weinstein, incarcerated at the Mohawk Correctional Facility, about 100 miles (160 kilometers) northwest of Albany, maintains his innocence. He contends any sexual activity was consensual.

A general view of Mohawk Correctional Facility in Rome, New York, where Harvey Weinstein is currently being held. (REUTERS)

His lawyers argued on appeal that the trial overseen by Judge James Burke was unfair because testimony was allowed from three women whose claims of unwanted sexual encounters with Weinstein were not part of the charges. Burke’s term expired at the end of 2022, and he is no longer a judge.
They also appealed the judge’s ruling that prosecutors could confront Weinstein over his long history of brutish behavior, including allegations of punching his movie producer brother at a business meeting, snapping at waiters, hiding a woman’s clothes and threatening to cut off a colleague’s genitals with gardening shears.
As a result, Weinstein, who wanted to testify, did not take the stand, Aidala said.
The appeals court labeled the allegations “appalling, shameful, repulsive conduct” but warned that “destroying a defendant’s character under the guise of prosecutorial need” did not justify some trial evidence and testimony.
In a majority opinion written by Judge Jenny Rivera, the Court of Appeals said defendants have a right to be held accountable “only for the crime charged and, thus, allegations of prior bad acts may not be admitted against them for the sole purpose of establishing their propensity for criminality.”
The Court of Appeals agreed last year to take Weinstein’s case after an intermediate appeals court upheld his conviction. Prior to their ruling, judges on the lower appellate court at oral arguments had raised doubts about Burke’s conduct. One observed that Burke let prosecutors pile on with “incredibly prejudicial testimony” from additional witnesses.
At a news conference, Aidala predicted that the lasting effect of the reversal would be that more defendants will testify at their trials, including Weinstein, who “will be able to tell his side of the story.”
He said that when he spoke to Weinstein on Thursday, his client told him: “I’ve been here for years in prison for something I didn’t do. You got to fix this.”
 


China’s Shenzhou-18 mission docks with space station

Updated 26 April 2024
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China’s Shenzhou-18 mission docks with space station

  • The astronauts took off from the Jiuquan Satellite Launch Center in China’s northwest at 8:59 p.m. local time Thursday
  • The astronauts will stay at the Tiangong space station for six months, carrying out experiments

JIUQUAN, China: A spaceship carrying three astronauts from China’s Shenzhou-18 mission safely docked at Tiangong space station Friday, state-run media reported, the latest step in Beijing’s space program that aims to send astronauts to the Moon by 2030.

The crew took off in a capsule atop a Long March-2F rocket from the Jiuquan Satellite Launch Center in China’s northwest at 8:59 p.m. local time 1259 GMT) Thursday.
By early Friday the spacecraft had “successfully docked” with the space station, state-run news agency Xinhua reported, citing the China Manned Space Agency.
The mission is led by Ye Guangfu, a fighter pilot and astronaut who was previously part of the Shenzhou-13 crew in 2021.
He is joined by astronauts Li Cong and Li Guangsu, who are heading into space for the first time.

Onlookers cheered as the rocket blasted off into the night sky, an AFP journalist at the scene said.
Xinhua said the launch had been declared a “complete success.”
The astronauts will stay at the Tiangong space station for six months.

There they plan to carry out experiments “in the fields of basic physics in microgravity, space material science, space life science, space medicine and space technology,” the China Manned Space Agency has said.
They will also try and create an aquarium onboard and seek to raise fish in zero gravity, according to Xinhua.
“Not only will the taikonauts find joy in the space ‘aquarium,’ but it may also pave the way for their future counterparts to enjoy nutritious fish from their own in-orbit harvests,” it added.

They will also conduct experiments on “fruit flies and mice,” a researcher quoted by the agency said.
The new crew will replace the Shenzhou-17 team, who were sent to the station in October.
Plans for China’s “space dream” have been put into overdrive under President Xi Jinping.
The world’s second-largest economy has pumped billions of dollars into its military-run space program in an effort to catch up with the United States and Russia.
Beijing also aims to send a crewed mission to the Moon by 2030, and plans to build a base on the lunar surface.
China has been effectively excluded from the International Space Station since 2011, when the United States banned NASA from engaging with the country — pushing Beijing to develop its own orbital outpost.
That station is the Tiangong, which means “heavenly palace” — the crown jewel of a space program that has landed robotic rovers on Mars and the Moon, and made China the third country to independently put humans in orbit.
It is constantly crewed by rotating teams of three astronauts, with construction completed in 2022.
The Tiangong is expected to remain in low Earth orbit at between 400 and 450 kilometers (250 and 280 miles) above the planet for at least 10 years.
 


Wave of pro-Palestinian campus protests in US meets forceful response

Updated 26 April 2024
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Wave of pro-Palestinian campus protests in US meets forceful response

  • Students protesters tasered and teargassed in Atlanta and "swept away" in Austin, Texas
  • More than 530 arrests have been made in the last week across major US universities in relation to protests over Gaza

NEW YORK: Fresh clashes between police and students opposed to Israel’s war in Gaza broke out on Thursday, raising questions about forceful methods being used to shut down protests that have intensified since mass arrests at Columbia University last week.

Over the past two days, law enforcement at the behest of college administrators have deployed Tasers and tear gas against students protesters at Atlanta’s Emory University, activists say, while officers clad in riot gear and mounted on horseback have swept away demonstrations at the University of Texas in Austin.
At Columbia, the epicenter of the US protest movement, university officials are locked in a stalemate with students over the removal of a tent encampment set up two weeks ago as a protest against the Israeli offensive.
The administration, which has already allowed an initial deadline for an agreement with students to lapse, has given protesters until Friday to strike a deal.
Other universities appear determined to prevent similar, long-running demonstrations to take root, opting to work with police to shut them down quickly and in some cases, with force.
Overall, more than 530 arrests have been made in the last week across major US universities in relation to protests over Gaza, according to a Reuters tally. University authorities have said the demonstrations are often unauthorized and called on police to clear them.

Police officers arrest a demonstrator during a pro-Palestinian protest against the war in Gaza at Emory University on April 25, 2024, in Atlanta, Georgia. (AFP)

At Emory, police detained at least 15 people on its Atlanta campus, according to local media, after protesters began erecting a tent encampment in an attempt to emulate a symbol of vigilance employed by protesters at Columbia and elsewhere.
The local chapter of the activist group Jewish Voice for Peace said officers used tear gas and Tasers to dispense the demonstration and take some protesters into custody.
Video footage aired on FOX 5 Atlanta showed a melee breaking out between officers and some protesters, with officers using what appeared to be a stun gun to subdue a person and others wrestling other protesters to the ground and leading them away.
“Several dozen protesters trespassed into Emory University’s campus early Thursday morning and set up tents,” the school wrote in response to an emailed request for comment. It described the protesters as “activists attempting to disrupt our university,” but did not comment directly on the reports of violence.
Atlanta police did not immediately respond to inquiries about the number of protesters who were detained or about reports over the use of tear gas and stun guns.
Similar scenarios unfolded on the New Jersey campus of Princeton University where officers swarmed a newly-formed encampment, video footage on social media showed.
Boston police earlier forcibly removed a pro-Palestinian encampment set up by Emerson College, arresting more than 100 people, media accounts and police said. The latest clashes came a day after police in riot gear and on horseback descended on hundreds of student protesters at the University of Texas at Austin and arrested dozens of them.

Police arrest a protester at the University of Texas on April 24, 2024, in Austin, Texas. (Austin American-Statesman via AP)

But prosecutors on Thursday dropped charges against most of the 60 people taken into custody, mostly on misdemeanor charges of criminal trespassing and disorderly conduct, and said they would proceed with only 14 of those cases.
In dropping the charges, the Travis County district attorney cited “deficiencies in the probable cause affidavits.”

‘Alarming reports’
Human Rights Watch and the American Civil Liberties Union have condemned the arrest of protesters and urged authorities to respect their free speech rights.
But some Republicans in Congress have accused university administrators of allowing Jewish students to be harassed, putting increasing pressure on schools to tightly control any demonstrations and to block any semi-permanent encampment.
US Education Secretary Miguel Cardona on Thursday said his department was closely monitoring the protests, including what he called “very alarming reports of antisemitism.”
In response, activist groups have strongly denied that the protests are antisemitic. Their aim is to pressure universities from divesting from companies that contribute to the Israeli military actions in Gaza, they say.
Even so, protest leaders have acknowledged that hateful rhetoric has been directed at Jewish students, but insist that people who tried to infiltrate and malign their movement are responsible for any harassment.

Columbia University students participate in an ongoing pro-Palestinian encampment on their campus in New York City on April 25, 2024, following last week's arrest of more than 100 protesters. (Getty Images/AFP)

Friday deadline at Columbia
At Columbia, officials have given protesters until 4 a.m. on Friday to reach an agreement with the university on dismantling dozens of tents set up on the New York City campus in a protest that started a week ago.
An initial deadline of midnight Tuesday came and went without an agreement, but administrators extended it for 48 hours, citing progress in the talks.
The university already tried to shut the protest down by force. On April 18, Columbia President Minouche Shafik took the unusual move of asking police to enter the campus, drawing the ire of many rights groups, students and faculty.
More than 100 people were arrested and the tents were removed from the main lawn. But within a few days, the encampment was back in place, and the university’s options appeared to narrow.
Protesters have vowed to keep the protests going until their universities agree to disclose and divest any financial holdings that might support the war in Gaza, and grant amnesty to students suspended from school during the demonstrations.
Student protesters have also demanded that the US government rein in Israeli strikes on civilians in Gaza, which have killed more than 34,000 people, according to Palestinian health authorities. Israel is retaliating against an Oct. 7 Hamas attack that killed 1,200 people and led to 253 taken hostage, according to Israeli tallies.


US Embassy marks 248th Independence Day with shared US-Saudi vision for space exploration 

Updated 25 April 2024
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US Embassy marks 248th Independence Day with shared US-Saudi vision for space exploration 

  • Ambassador Michael Ratney welcomes hundreds of Saudi guests to space-themed Riyadh reception

RIYADH: The US Embassy in Riyadh celebrated the 248th anniversary of Independence Day on Thursday with a reception hosted by US Ambassador Michael Ratney. 

The ambassador welcomed guest of honor Prince Faisal bin Abdulaziz bin Ayyaf, Riyadh Region mayor, along with Saudi officials, and hundreds of Saudi guests, as well as visitors from Washington, including members of the US Congress.  

The space-themed Independence Day reception served as a symbolic celebration of the future of the US-Saudi cooperation in space, highlighting the profound benefits and possibilities of space exploration, research, and commercial development.

Ratney said the theme reflects the “shared ambition of the United States and Saudi Arabia to embrace opportunities in space, positioning both countries as pioneers in this frontier of innovation.” 

The event evoked nostalgia for past achievements, such as the 1969 moon landing, while emphasizing ongoing advancements in space sciences, particularly commercial space exploration. 

Ratney highlighted Saudi pioneers in space travel, such as Prince Sultan bin Salman, and astronauts Rayyanah Barnawi and Ali Al-Qarni. 

An art installation, “Museum of the Moon,” by artist Luke Jerram, featured NASA’s high-definition imagery of the lunar surface. 

According to the US Embassy’s statement, the collaboration between the US and Saudi Arabia continues to advance shared interests in diplomacy, commerce, culture, and more.

The US remains dedicated to enhancing shared US-Saudi shared interests in security and in fostering prosperity in the region, while also exploring new avenues for partnerships in areas such as the arts, education, entertainment, and tourism, it said.

Both countries are poised to explore further cooperation, including potential joint ventures in space, reflecting a vision for an even stronger US-Saudi relationship in the future, the statement added. 


Where We Are Going Today: Mr Chow, a Chinese restaurant in Riyadh

Updated 25 April 2024
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Where We Are Going Today: Mr Chow, a Chinese restaurant in Riyadh

If you are a fan of Chinese cuisine, you must check out Mr Chow’s restaurant, which opened in the King Abdullah Financial District in Riyadh.

Specializing in real Chinese food, Mr Chow is located in the district’s upscale neighborhood, close to Zuma Lounge. Valet parking is available for your convenience.   

The smart venue is open daily for dinner and it’s exactly the sort of grand, modern spot you’d expect in the area. The glossy black entrance with neon artwork opens up to two floors of sprawling seats with white tablecloths, a spiral staircase, and staff in immaculate white outfits. 

Entering this establishment, you will be greeted with excellent service and a romantic atmosphere.   

The appetizers are a taste adventure in and of themselves You can begin your culinary journey with an appetizer of pot stickers, chicken satay, or glazed prawns with walnuts.

Following starters, opt for the Ma Mignon, a traditional tender fillet mignon served with fried rice on the side, or the fresh lobster. For dessert, be sure to try the rich chocolate cake. 

The food is presented wonderfully. You will love watching the chef skillfully work the dough live to make noodles. While enjoying your dinner, you can choose to sit outside and take in the stunning view of the financial district’s tall buildings and contemporary architecture.  

Who is Mr Chow? 

Michael Chow, founder and owner of the Mr Chow restaurant chain, is an actor, interior designer, artist, and British-Chinese restaurateur.

On Valentine’s Day 1968, London saw the opening of the first Mr Chow restaurant, where elite chefs served real Beijing cuisine along with novel creations, including Ma Mignon.

For half a century, clients have enjoyed watching the nightly handmade noodle show at all of the locations, and on the menu is one of the best-prepared Beijing ducks in the world. 

For more details, visit @mrchowriyadh.