DUBAI: Moderna’s stock soared Tuesday after the COVID-19 vaccine maker detailed progress in developing a preventive shot for a deadly form of skin cancer.
The company said a possible melanoma vaccine it is studying with pharmaceutical giant Merck fared well in a small study of patients who had the cancer surgically removed.
The drugmakers said a combination of the vaccine and Merck’s immunotherapy Keytruda led to a statistically significant improvement in survival before the cancer returned in patients with advanced melanoma.
“We are very excited, we are moving very quickly with Merck onto phase 3 for this study,” Moderna CEO Stephane Bancel told CNBC Tuesday morning.
Phase 3 is generally the largest and most expensive stage of clinical research before regulators review a potential drug for approval.
Moderna developed one of the most popular vaccines used to protect patients against COVID-19, and the drugmaker brought in more than $3 billion from its Spikevax in this year’s third quarter.
But vaccine use has slowed, and Moderna depends on Spikevax for nearly all its revenue.
Like Spikevax, the potential skin cancer vaccine uses mRNA technology. It trains a patient’s immune system to recognize and respond specifically to mutations in the DNA of the patient’s tumor.
In a mid-stage clinical trial involving 157 patients, researchers compared the vaccine-Keytruda combination with Keytruda alone.
Keytruda, Merck’s top seller, primes the body’s immune system to detect and fight tumor cells. Regulators have approved it to treat several types of cancer.
The patient group that took the potential vaccine and Keytruda saw a 44 percent reduction in the risk of death or the cancer returning, the companies said.
The treatments continued for about a year in both groups unless the disease came back or side effects became too severe.
Merck and Moderna expect to start a phase 3 study next year, and the companies say they intend to expand their approach to other tumor types.
Merck and Moderna established an agreement to work together in 2016, and the companies plan to share costs and profits in their collaboration. Merck also paid Moderna $250 million.
Shares of Cambridge, Massachusetts-based Moderna Inc. soared 23 percent to top $200 in midday trading while broader indexes climbed. Kenilworth, New Jersey-based Merck & Co. climbed less than 1 percent.
Merck, Moderna detail potential skin cancer vaccine progress
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Merck, Moderna detail potential skin cancer vaccine progress
- The company said a possible melanoma vaccine it is studying with pharmaceutical giant Merck fared well in a small study of patients
- “We are very excited, we are moving very quickly with Merck onto phase 3 for this study,” Moderna CEO Stephane Bancel
Deputy leader of UK’s Labour Party promises to fight to end Gaza’s suffering, in leaked video
- Labour, if elected, would recognize Palestinian statehood, says Angela Rayner
LONDON: Angela Rayner, the deputy leader of the UK’s Labour Party, has promised that her party will do everything in its power to ease the suffering in Gaza as it bids to regain Muslim voters’ support, a leaked video surfacing on social media has revealed.
The footage was first reported by the political blog Guido Fawkes, which claimed to have obtained the leaked tape from a meeting in Ashton-under-Lyne, Rayner’s constituency.
The MP is seen appealing to voters upset with the party’s stance on Israel’s assault on Gaza, The Telegraph reported.
Rayner — claiming she worked “day and night” to get three British doctors out of Rafah and is now attempting to secure aid for the enclave — said: “I promise you, the Labour Party, including myself, is doing everything we can, because nobody wants to see what’s happening.”
She acknowledged the party’s current inability to halt the fighting, admitting that Labour’s influence would be “limited,” even if it came to power after July’s general election.
Rayner added: “Only last week the Labour Party were supporting the ICC (International Criminal Court). The Conservatives didn’t support the ICC, so with this general election on that issue, we can’t affect anything when we’re not in government.
“And I’ll be honest with you, if Labour gets into government, we are limited. I will be honest. I’m not going to promise you … because (Joe) Biden, who’s the US (president), who has way more influence, has only got limited influence in that.
“And Qatar, Saudi Arabia, all of these people, we are all working to stop what’s happening at the moment; we want to see that. So I promise you, that’s what we want to see.”
Rayner also promised that, if Labour was elected, the party would recognize Palestinian statehood.
She added: “If Labour gets into power, we will recognize Palestine. I will push not only to recognize … there is nothing to recognize at the moment, sadly. It’s decimated.
“We have to rebuild Palestine; we have to rebuild Gaza. That takes more than just recognizing it.”
Gaza has been a divisive issue for Labour since Oct. 7, with reports revealing that Muslim voters have abandoned the party as a result of what they perceive as its politicians enabling the war.
The Telegraph found that Labour’s support had dropped in local elections in areas with large Muslim populations, including Oldham in Greater Manchester, where the party lost control of the council in a surprise defeat.
Labour leader Keir Starmer has expressed his determination to re-establish trust among those who have abandoned his party due to his handling of the Gaza war.
However, when probed on particular commitments, he remained vague.
Rayner said in the video: “I know that people are angry about what’s happening in the Middle East.
“If my resignation as an MP now would bring a ceasefire, I would do it. I would do it if I could effect change.”
However, she said such an eventuality was not “in my gift” due to the “failure of the international community.”
In response to the footage, Nigel Farage, Reform UK’s honorary president, accused Rayner of “begging” for the Muslim vote, The Telegraph reported.
12 Indians killed in quarry collapse after cyclone rains
- Several highways and key roads were disrupted by landslides, and all schools were shut
- India’s weather office warned of extremely heavy rains in northeastern states on Tuesday
Guwahati: Torrential rains in the wake of a powerful cyclone caused the collapse of a quarry in India’s Mizoram state killing 12 people, government officials said Tuesday.
“So far 12 bodies have been found, we are looking for more,” deputy commissioner of Aizawl district Nazuk Kumar told AFP.
Rescue efforts in the quarry were being hampered by “heavy rains,” police director general Anil Shukla said, NDTV news network reported.
Mizoram Chief Minister Lalduhoma offered compensation to families of the victims of the “landslide due to Cyclone Remal.”
“I pray for the success of rescue and relief operations and wish a speedy recovery of the injured,” India’s President Droupadi Murmu said on social media.
In Mizoram, several highways and key roads were disrupted by landslides. All schools were shut and government employees asked to work from home.
India’s weather office has issued warnings of extremely heavy rainfall across Mizoram and other northeastern states on Tuesday.
In India’s neighboring Assam state, one person was killed and heavy rains had cut the power supply, Chief Minister Himanta Biswa Sarma said in a statement.
The cyclone made landfall in low-lying Bangladesh and neighboring India on Sunday evening with fierce gales and crashing waves.
Overall, at least 38 people died in the cyclone or storms in its wake.
In India, eight people died in West Bengal state, officials said Tuesday, updating an earlier toll of six, taking the total killed in the country to at least 21.
In neighboring Bangladesh, which bore the brunt of the cyclone that made landfall on Sunday, at least 17 people died, according to the disaster management office and police.
Poland’s foreign minister says it should not exclude the possibility of sending troops to Ukraine
- Radek Sikorski made the comments in an interview published Tuesday in the Gazeta Wyborcza daily
- “We should not exclude any option. Let Putin be guessing as to what we will do”
WARSAW: Poland’s foreign minister says the NATO nation should not exclude the possibility of sending troops to Ukraine and should keep Russian President Vladimir Putin in suspense over whether such a decision would ever be made.
Radek Sikorski made the comments in an interview published Tuesday in the Gazeta Wyborcza daily.
“We should not exclude any option. Let Putin be guessing as to what we will do,” Sikorski said when asked whether he would send Polish troops to Ukraine.
Sikorski said he has gone to Ukraine with his family to deliver humanitarian aid.
But a spokesperson for Poland’s Defense Ministry, Janusz Sejmej, told Polish media on Tuesday he had “no knowledge of that” when asked about a report in Germany’s Der Spiegel magazine suggesting Poland might send troops to Ukraine.
The idea of sending foreign soldiers to Ukraine, which is battling Russian military aggression, was floated earlier this year in France, but no country, including Poland, has publicly embraced it.
Poland supports neighboring Ukraine politically and by providing military equipment and humanitarian aid.
Baby found dead in stricken migrant boat heading for Italy
- The infant girl, her mother and 4-year-old sister were in an unseaworthy boat laden with migrants that had set off from Sfax in Tunisia
- SOS Humanity workers aboard its “Humanity 1” vessel found many of the migrants exhausted
LAMPEDUSA, Italy: The body of a five-month-old baby was found on Tuesday when some 85 migrants heading for Italy from Tunisia were rescued from distress at sea, according to a Reuters witness.
The infant girl, her mother and 4-year-old sister were in an unseaworthy boat laden with migrants that had set off from Sfax in Tunisia two days earlier bound for Italy, according to charity group SOS Humanity.
SOS Humanity workers aboard its “Humanity 1” vessel found many of the migrants exhausted and suffering from seasickness and fuel burns as they were rescued before dawn on Tuesday, the group said in a statement.
Some 185 migrants rescued in separate operations this week, including the stricken boat overnight, were being taken aboard “Humanity 1” to the port of Livorno in northwest Italy. Another 120 migrants were transferred by coast guard boat to the Italian island of Lampedusa in the southern Mediterranean.
Tunisia is grappling with a migrant crisis and has replaced Libya as the main departure point for people fleeing poverty and conflict further south in Africa as well as the Middle East in hopes of a better life in Europe.
Italy has sought to curb migrant arrivals from Africa, making it harder charity ships to operate in the Mediterranean, limiting the number of rescues they can carry out and often forcing them to make huge detours to bring migrants ashore.
Putin says Ukraine should hold presidential election
- Zelensky has not faced an election despite the expiry of his term
MOSCOW: Russian President Vladimir Putin said on Tuesday Ukraine should hold a presidential election following the expiry of President Volodymyr Zelensky’s five-year term.
Zelensky has not faced an election despite the expiry of his term, something he and Kyiv’s allies deem the right decision in wartime. Putin said the only legitimate authority in Ukraine now was parliament, and that its head should be given power.
