Malawi becomes 1st nation to immunize kids against malaria

A Health Surveilance Assistant prepares to give a dose of the Malaria Vaccinne into the first recipient on April 23, 2019 at Mitundu Community hospital in Malawi's capital district of Lilongwe on the first day of the Malaria vaccine implementation pilot programme in Malawi aiming to immunise 120,000 children aged two years and under to assess the effectiveness of the pilot vaccine and whether the delivery process is feasible. (AFP)
Updated 24 April 2019
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Malawi becomes 1st nation to immunize kids against malaria

  • The vaccine, known as Mosquirix, was developed by GlaxoSmithKline and was approved by the European Medicines Agency in 2015

LONDON: The World Health Organization says Malawi has become the first country to begin immunizing children against malaria, using the only licensed vaccine to protect against the mosquito-spread disease.
Although the vaccine only protects about one-third of children who are immunized, those who get the shots are likely to have less severe cases of malaria. The parasitic disease kills about 435,000 people every year, the majority of them children under 5 in Africa.
“It’s an imperfect vaccine but it still has the potential to save tens of thousands of lives,” said Alister Craig, dean of biological sciences at the Liverpool School of Tropical Medicine, who is not linked to WHO or vaccine. Craig said immunizing the most vulnerable children during peak malaria seasons could spare many thousands from falling ill or even dying.
The vaccine, known as Mosquirix, was developed by GlaxoSmithKline and was approved by the European Medicines Agency in 2015. A previous trial showed the vaccine was about 30% effective in children who got four doses, but that protection waned over time. Reported side effects include pain, fever and convulsions.
Pedro Alonso, director of WHO’s malaria program, said similar vaccination programs would begin in the coming weeks in Kenya and Ghana, with the aim of reaching about 360,000 children per year across the three countries.
Alonso called the vaccination rollout a “historical moment,” noting that it was significantly more difficult to design a vaccine against a parasite as opposed to a bacterium or virus.
He acknowledged the vaccine was flawed but said the world could not afford to wait for a better option. “We don’t know how long it will take to develop the next-generation vaccine,” he said. “It may be many, many years away.”
In the meantime, he said, the stalled progress against malaria demanded new tools now. Resistance is growing to medicines that treat the disease, while mosquitoes are becoming more resistant to insecticides. In addition, funding for malaria efforts has plateaued in recent years.
It took GSK and partners more than 30 years to develop the vaccine, at a cost of around $1 billion. GSK is donating up to 10 million vaccine doses in the current vaccination initiatives. A company spokesman said GSK is working with partners to secure funding for potentially broader vaccination programs.
Some experts warned the vaccination programs should not divert limited public health funds from inexpensive and proven tools to curb malaria such as bed nets and insecticides.
“This is a bold thing to do, but it’s not a silver bullet,” said Thomas Churcher, a malaria expert at Imperial College London. “As long as using the vaccine doesn’t interfere with other efforts, like the urgent need for new insecticides, it is a good thing to do.”
Craig said one of health officials’ biggest challenges could be convincing parents to bring their children for repeated doses of a vaccine that only protects about a third of children for a limited amount of time.
More commonly used vaccines, like those for polio and measles, work more than 90 percent of the time.
“This malaria vaccine is going to save many lives, even if it is not as good as we would like,” Craig said. “But I hope this will kick-start other research efforts so that the story doesn’t end here.”


Italian hostage freed after 3 years in Syria returns home

Updated 23 May 2019
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Italian hostage freed after 3 years in Syria returns home

  • The man who disappeared traveled to Turkey in October 2016
  • An official said the man was kidnapped by a criminal gang

MILAN: Italy’s defense minister says an Italian who had been held hostage in Syria for three years has been released and returned to Italy.

Defense Minister Elisabetta Trenta late Wednesday confirmed Alessandro Sandrini’s arrival at Rome’s Ciampino airport and thanked Italian intelligence services for their role in his liberation. Details were not disclosed.

Sandrini, who is in his early 30s, disappeared after traveling to Turkey in October 2016, and wasn’t heard from for over a year. In July 2018, a dramatic video showed Sandrini wearing an orange jumpsuit flanked by masked men brandishing automatic weapons, appealing to Italy to help free him as quickly as possible.

A local government in Syria affiliated with the Al-Qaeda-linked militant group Hayat Tahir-al Sham said he had been kidnapped by a criminal gang.